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Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State.

Abstract

BACKGROUND

The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data.

METHODS

Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression.

RESULTS

Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011 [corrected]. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. HR+/HER2- breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100000 non-Hispanic white women, respectively). HR+/HER2- breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P < .001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100000 non-Hispanic black women), which is reflected in high rates in southeastern states.

CONCLUSIONS

Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection standards to produce clinically relevant data based on evolving medical knowledge.

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  • Authors+Show Affiliations

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA). bkohler@naaccr.org.

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    ,

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    North American Association of Central Cancer Registries, Springfield, IL (BAK, RLS, KAH, FPB); National Cancer Institute, Bethesda, MD (NH, KAC, AMN, LP); American Cancer Society, Atlanta, GA (AJ); Centers for Disease Control and Prevention, Atlanta, GA (ABR, SJH, CRE); Temple University Department of Geography, Philadelphia, PA (KAH); New York State Cancer Registry, NY (FPB); Information Management Services, Inc., Rockville, MD (AL); National Center for Health Statistics, Hyattsville, MD (RNA).

    Source

    MeSH

    Adult
    African Americans
    Age Distribution
    Aged
    Aged, 80 and over
    Biomarkers, Tumor
    Breast Neoplasms
    Breast Neoplasms, Male
    Confounding Factors (Epidemiology)
    Continental Population Groups
    Early Detection of Cancer
    Ethnic Groups
    European Continental Ancestry Group
    Female
    Hispanic Americans
    Humans
    Incidence
    Male
    Mammography
    Middle Aged
    Neoplasm Staging
    Poverty
    Prognosis
    Receptor, ErbB-2
    Receptors, Estrogen
    Receptors, Progesterone
    Registries
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    25825511

    Citation

    Kohler, Betsy A., et al. "Annual Report to the Nation On the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes By Race/Ethnicity, Poverty, and State." Journal of the National Cancer Institute, vol. 107, no. 6, 2015, pp. djv048.
    Kohler BA, Sherman RL, Howlader N, et al. Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State. J Natl Cancer Inst. 2015;107(6):djv048.
    Kohler, B. A., Sherman, R. L., Howlader, N., Jemal, A., Ryerson, A. B., Henry, K. A., ... Penberthy, L. (2015). Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State. Journal of the National Cancer Institute, 107(6), pp. djv048. doi:10.1093/jnci/djv048.
    Kohler BA, et al. Annual Report to the Nation On the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes By Race/Ethnicity, Poverty, and State. J Natl Cancer Inst. 2015;107(6):djv048. PubMed PMID: 25825511.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State. AU - Kohler,Betsy A, AU - Sherman,Recinda L, AU - Howlader,Nadia, AU - Jemal,Ahmedin, AU - Ryerson,A Blythe, AU - Henry,Kevin A, AU - Boscoe,Francis P, AU - Cronin,Kathleen A, AU - Lake,Andrew, AU - Noone,Anne-Michelle, AU - Henley,S Jane, AU - Eheman,Christie R, AU - Anderson,Robert N, AU - Penberthy,Lynne, Y1 - 2015/03/30/ PY - 2015/4/1/entrez PY - 2015/4/1/pubmed PY - 2015/6/30/medline SP - djv048 EP - djv048 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 107 IS - 6 N2 - BACKGROUND: The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. METHODS: Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. RESULTS: Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011 [corrected]. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. HR+/HER2- breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100000 non-Hispanic white women, respectively). HR+/HER2- breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P < .001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100000 non-Hispanic black women), which is reflected in high rates in southeastern states. CONCLUSIONS: Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection standards to produce clinically relevant data based on evolving medical knowledge. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/25825511/Annual_Report_to_the_Nation_on_the_Status_of_Cancer_1975_2011_Featuring_Incidence_of_Breast_Cancer_Subtypes_by_Race/Ethnicity_Poverty_and_State_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djv048 DB - PRIME DP - Unbound Medicine ER -