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Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae.
Environ Sci Technol 2015; 49(8):5123-32ES

Abstract

Organophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 μg/L) for 3 months. Increased generation of reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3'-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., α1-tubulin, myelin basic protein, and synapsin IIa) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity.

Authors+Show Affiliations

†State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China. ‡University of Chinese Academy of Sciences, Beijing 100049, China.§State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China. ∥Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity, City University of Hong Kong Shenzhen Research Institute Building, Shenzhen, Guangdong 518057, China. ⊥Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, China.†State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China. ‡University of Chinese Academy of Sciences, Beijing 100049, China.†State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.§State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China. ∥Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity, City University of Hong Kong Shenzhen Research Institute Building, Shenzhen, Guangdong 518057, China. ⊥Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, China.∥Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity, City University of Hong Kong Shenzhen Research Institute Building, Shenzhen, Guangdong 518057, China.†State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25826601

Citation

Wang, Qiangwei, et al. "Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae." Environmental Science & Technology, vol. 49, no. 8, 2015, pp. 5123-32.
Wang Q, Lai NL, Wang X, et al. Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae. Environ Sci Technol. 2015;49(8):5123-32.
Wang, Q., Lai, N. L., Wang, X., Guo, Y., Lam, P. K., Lam, J. C., & Zhou, B. (2015). Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology, 49(8), pp. 5123-32. doi:10.1021/acs.est.5b00558.
Wang Q, et al. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae. Environ Sci Technol. 2015 Apr 21;49(8):5123-32. PubMed PMID: 25826601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae. AU - Wang,Qiangwei, AU - Lai,Nelson Lok-Shun, AU - Wang,Xianfeng, AU - Guo,Yongyong, AU - Lam,Paul Kwan-Sing, AU - Lam,James Chung-Wah, AU - Zhou,Bingsheng, Y1 - 2015/04/09/ PY - 2015/4/1/entrez PY - 2015/4/1/pubmed PY - 2016/4/26/medline SP - 5123 EP - 32 JF - Environmental science & technology JO - Environ. Sci. Technol. VL - 49 IS - 8 N2 - Organophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 μg/L) for 3 months. Increased generation of reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3'-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., α1-tubulin, myelin basic protein, and synapsin IIa) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/25826601/Bioconcentration_and_transfer_of_the_organophorous_flame_retardant_13_dichloro_2_propyl_phosphate_causes_thyroid_endocrine_disruption_and_developmental_neurotoxicity_in_zebrafish_larvae_ L2 - https://dx.doi.org/10.1021/acs.est.5b00558 DB - PRIME DP - Unbound Medicine ER -