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Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers.
Exp Gerontol. 2015 Jun; 66:10-6.EG

Abstract

OBJECTIVE

This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency.

METHODS

A double blind, randomized, placebo-controlled trial was conducted with 40 elderly women (aged 68±6 years) diagnosed with vitamin D insufficiency (24.7±3.1 ng/mL). Participants were distributed into a supplementation group that received 200,000 IU of vitamin D3 (SG; n=20) and a placebo group (PG; n=20). Blood samples were collected at baseline and after intervention to analyse the 25(OH)D, parathyroid hormone, serum calcium, ultra-sensitive C-reactive protein (us-CRP), alpha 1-acid glycoprotein (AGP-A), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels, as well as the renal and hepatic function, and genotyping was performed for BsmI polymorphism.

RESULTS

Four weeks after supplementation, elderly women in the SG group showed a significant increase in the serum concentration of 25(OH)D (25.29±2.8 to 31.48±6.0; p=0.0001), which was followed by increased TAC (65.25±15.66 to 71.83±10.71; p=0.03) and decreased serum PTH (46.32±13.2 to 35.45±11.0; p=0.009), us-CRP (0.38±0.3 to 0.19±0.1; p=0.007) and AGP-A levels (75.3±15.4 to 61.1±5.9; p=0.005). Changes in BP, ANAC and MDA were not observed. The 25(OH)D and PTH, us-CRP and AGP-A levels of participants with the BB/Bb genotype were more responsive to supplementation, but their other markers did not change.

CONCLUSIONS

Supplementation with a vitamin D3 megadose reduced inflammatory markers and increased the total antioxidant capacity in elderly women with vitamin D insufficiency. The 25(OH)D, PTH, us-CRP and AGP-A levels of elderly patients with the BB/Bb genotype were more responsive to supplementation compared with those with the bb genotype.

Authors+Show Affiliations

Graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. Electronic address: isa.gabriela@hotmail.com.Graduate Program in Nutrition Sciences, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.Graduate Program in Nutrition Sciences, Department of Nutrition, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.Graduate Program in Cellular and Molecular Biology, Department of Molecular Biology, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.No affiliation info availableGraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.João Pessoa City Hall, Paraíba, Brazil.Graduate Program in Nutrition Sciences, Department of Nutrition, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25827670

Citation

de Medeiros Cavalcante, Isa Gabriela, et al. "Effect of Vitamin D3 Supplementation and Influence of BsmI Polymorphism of the VDR Gene of the Inflammatory Profile and Oxidative Stress in Elderly Women With Vitamin D Insufficiency: Vitamin D3 Megadose Reduces Inflammatory Markers." Experimental Gerontology, vol. 66, 2015, pp. 10-6.
de Medeiros Cavalcante IG, Silva AS, Costa MJ, et al. Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers. Exp Gerontol. 2015;66:10-6.
de Medeiros Cavalcante, I. G., Silva, A. S., Costa, M. J., Persuhn, D. C., Issa, C. T., Issa, C. I., de Luna Freire, T. L., & da Conceição Rodrigues Gonçalves, M. (2015). Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers. Experimental Gerontology, 66, 10-6. https://doi.org/10.1016/j.exger.2015.03.011
de Medeiros Cavalcante IG, et al. Effect of Vitamin D3 Supplementation and Influence of BsmI Polymorphism of the VDR Gene of the Inflammatory Profile and Oxidative Stress in Elderly Women With Vitamin D Insufficiency: Vitamin D3 Megadose Reduces Inflammatory Markers. Exp Gerontol. 2015;66:10-6. PubMed PMID: 25827670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers. AU - de Medeiros Cavalcante,Isa Gabriela, AU - Silva,Alexandre Sérgio, AU - Costa,Maria José Carvalho, AU - Persuhn,Darlene Camati, AU - Issa,Chahira Taha Mahd Ibrahim, AU - Issa,ChariraTahaMad Ibraim, AU - de Luna Freire,Tiago Lima, AU - da Conceição Rodrigues Gonçalves,Maria, Y1 - 2015/03/28/ PY - 2014/11/19/received PY - 2015/03/14/revised PY - 2015/03/27/accepted PY - 2015/4/2/entrez PY - 2015/4/2/pubmed PY - 2016/1/23/medline KW - BsmI polymorphism KW - Elderly KW - Inflammation and oxidative stress KW - Supplementation KW - Vitamin D3 SP - 10 EP - 6 JF - Experimental gerontology JO - Exp Gerontol VL - 66 N2 - OBJECTIVE: This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS: A double blind, randomized, placebo-controlled trial was conducted with 40 elderly women (aged 68±6 years) diagnosed with vitamin D insufficiency (24.7±3.1 ng/mL). Participants were distributed into a supplementation group that received 200,000 IU of vitamin D3 (SG; n=20) and a placebo group (PG; n=20). Blood samples were collected at baseline and after intervention to analyse the 25(OH)D, parathyroid hormone, serum calcium, ultra-sensitive C-reactive protein (us-CRP), alpha 1-acid glycoprotein (AGP-A), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels, as well as the renal and hepatic function, and genotyping was performed for BsmI polymorphism. RESULTS: Four weeks after supplementation, elderly women in the SG group showed a significant increase in the serum concentration of 25(OH)D (25.29±2.8 to 31.48±6.0; p=0.0001), which was followed by increased TAC (65.25±15.66 to 71.83±10.71; p=0.03) and decreased serum PTH (46.32±13.2 to 35.45±11.0; p=0.009), us-CRP (0.38±0.3 to 0.19±0.1; p=0.007) and AGP-A levels (75.3±15.4 to 61.1±5.9; p=0.005). Changes in BP, ANAC and MDA were not observed. The 25(OH)D and PTH, us-CRP and AGP-A levels of participants with the BB/Bb genotype were more responsive to supplementation, but their other markers did not change. CONCLUSIONS: Supplementation with a vitamin D3 megadose reduced inflammatory markers and increased the total antioxidant capacity in elderly women with vitamin D insufficiency. The 25(OH)D, PTH, us-CRP and AGP-A levels of elderly patients with the BB/Bb genotype were more responsive to supplementation compared with those with the bb genotype. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/25827670/Effect_of_vitamin_D3_supplementation_and_influence_of_BsmI_polymorphism_of_the_VDR_gene_of_the_inflammatory_profile_and_oxidative_stress_in_elderly_women_with_vitamin_D_insufficiency:_Vitamin_D3_megadose_reduces_inflammatory_markers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(15)00103-5 DB - PRIME DP - Unbound Medicine ER -