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Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia.
Ann Saudi Med. 2014 Sep-Oct; 34(5):396-400.AS

Abstract

BACKGROUND AND OBJECTIVES

Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-a2b in the management of MERS CoV at a tertiary care hospital.

DESIGN AND SETTINGS

A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-a2b in addition to supportive management. The patients' demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV.

METHODS

Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription-polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients' demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded.

RESULTS

Three out of 6 patients who had comorbid conditions died during the study period, while 3 had suc.cessful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV.

CONCLUSION

Treatment with ribavirin and IFN-a2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients.

Authors+Show Affiliations

Dr. Mohammad Khalid, Department of Medicine, King Faisal Specialist Hospital & Research Center PO Box 3354 Riyadh 11211 Saudi Arabia, mkhalid@kfshrc.edu.sa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25827696

Citation

Khalid, Mohammad, et al. "Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): Case Reports From a Tertiary Care Hospital in Saudi Arabia." Annals of Saudi Medicine, vol. 34, no. 5, 2014, pp. 396-400.
Khalid M, Khan B, Al Rabiah F, et al. Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia. Ann Saudi Med. 2014;34(5):396-400.
Khalid, M., Khan, B., Al Rabiah, F., Alismaili, R., Saleemi, S., Rehan-Khaliq, A. M., Weheba, I., Al Abdely, H., Halim, M., Nadri, Q. J., Al Dalaan, A. M., Zeitouni, M., Butt, T., & Al Mutairy, E. (2014). Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia. Annals of Saudi Medicine, 34(5), 396-400. https://doi.org/10.5144/0256-4947.2014.396
Khalid M, et al. Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): Case Reports From a Tertiary Care Hospital in Saudi Arabia. Ann Saudi Med. 2014 Sep-Oct;34(5):396-400. PubMed PMID: 25827696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia. AU - Khalid,Mohammad, AU - Khan,Basha, AU - Al Rabiah,Fahad, AU - Alismaili,Ruwaida, AU - Saleemi,Sarfraz, AU - Rehan-Khaliq,Agha Muhammad, AU - Weheba,Ihab, AU - Al Abdely,Hail, AU - Halim,Magid, AU - Nadri,Quaid Johar, AU - Al Dalaan,Abdullah Mohsin, AU - Zeitouni,Mohamed, AU - Butt,Taimur, AU - Al Mutairy,Eid, PY - 2015/4/2/entrez PY - 2015/4/2/pubmed PY - 2015/11/18/medline SP - 396 EP - 400 JF - Annals of Saudi medicine JO - Ann Saudi Med VL - 34 IS - 5 N2 - BACKGROUND AND OBJECTIVES: Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-a2b in the management of MERS CoV at a tertiary care hospital. DESIGN AND SETTINGS: A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-a2b in addition to supportive management. The patients' demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV. METHODS: Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription-polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients' demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded. RESULTS: Three out of 6 patients who had comorbid conditions died during the study period, while 3 had suc.cessful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV. CONCLUSION: Treatment with ribavirin and IFN-a2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients. SN - 0975-4466 UR - https://www.unboundmedicine.com/medline/citation/25827696/Middle_Eastern_Respiratory_Syndrome_Corona_Virus__MERS_CoV_:_case_reports_from_a_tertiary_care_hospital_in_Saudi_Arabia_ L2 - https://www.annsaudimed.net/doi/10.5144/0256-4947.2014.396?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -