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Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan.
J Ethnopharmacol. 2015 Jun 20; 168:129-35.JE

Abstract

ETHNO-PHARMACOLOGICAL RELEVANCE

Chinese herbal products (CHPs) are commonly used in patients with hyperlipidemia in traditional Chinese medicine (TCM). Because hyperlipidemia and related disease are common issues worldwide, this study analyzed the prescription patterns and frequencies of CHPs for treating patients with hyperlipidemia in Taiwan.

BACKGROUND

Traditional Chinese medicine (TCM) has become popular as a therapy for controlling symptoms in patients with hyperlipidemia. This study aimed to analyze the prescription patterns of TCM for patients with hyperlipidemia in Taiwan.

METHODS

The study population was recruited from a random-sampled cohort of 1,000,000 people from the National Health Insurance Research Database between 2003 and 2009. We identified 30,784 outpatient visits related with hyperlipidemia diagnosis and collected these medical records. Association rules of data mining were conducted to explore the co-prescription patterns for Chinese herbal products (CHPs).

RESULTS

The most commonly prescribed herbal formula for hyperlipidemia treatment was Xue-Fu-Zhu-Yu-Tang (16.1%), and Shan Zha (Crataegi fructus; 25.0%) was the most commonly prescribed single herb. The most commonly prescribed combination of an herbal formula and a single herb was Xue-Fu-Zhu-Yu-Tang and Dan Shen (Radix Salviae Miltiorrhizae), and the most commonly prescribed combination of couplet herbs was Dan Shen and Shan Zha.

CONCLUSION

Xue-Fu-Zhu-Yu-Tang is the most frequently prescribed formula and is typically prescribed with Shan Zha, Dan Shen, and He Shou Wu for patients with hyperlipidemia. Clinical trials are warranted in future research to investigate the effects of the CHPs in terms of safety and efficacy and in particular to evaluate potential interactions with conventional treatments.

Authors+Show Affiliations

Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan.Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 10055, Taiwan.Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 10055, Taiwan; Center of Excellence for Chang Gung Research Datalink, Chang Gung Memorial Hospital, Chiayi, Taiwan.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 10055, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei 10055, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10055, Taiwan.Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan. Electronic address: cherrychu36@cgmh.org.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25828254

Citation

Chu, Shih-Meng, et al. "Use of Traditional Chinese Medicine in Patients With Hyperlipidemia: a Population-based Study in Taiwan." Journal of Ethnopharmacology, vol. 168, 2015, pp. 129-35.
Chu SM, Shih WT, Yang YH, et al. Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan. J Ethnopharmacol. 2015;168:129-35.
Chu, S. M., Shih, W. T., Yang, Y. H., Chen, P. C., & Chu, Y. H. (2015). Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan. Journal of Ethnopharmacology, 168, 129-35. https://doi.org/10.1016/j.jep.2015.03.047
Chu SM, et al. Use of Traditional Chinese Medicine in Patients With Hyperlipidemia: a Population-based Study in Taiwan. J Ethnopharmacol. 2015 Jun 20;168:129-35. PubMed PMID: 25828254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan. AU - Chu,Shih-Meng, AU - Shih,Wei-Tai, AU - Yang,Yao-Hsu, AU - Chen,Pau-Chung, AU - Chu,Yen-Hua, Y1 - 2015/03/28/ PY - 2014/10/23/received PY - 2015/03/18/revised PY - 2015/03/19/accepted PY - 2015/4/2/entrez PY - 2015/4/2/pubmed PY - 2016/3/31/medline KW - Chinese herbal products KW - Hyperin (PubChem CID: 5281643) KW - Hyperlipidemia KW - NHIRD KW - Prescription pattern KW - Traditional chinese medicine KW - Triterpenic acids (PubChem CID: 451674) KW - Ursolic acid (PubChem CID: 64945) SP - 129 EP - 35 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 168 N2 - ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHPs) are commonly used in patients with hyperlipidemia in traditional Chinese medicine (TCM). Because hyperlipidemia and related disease are common issues worldwide, this study analyzed the prescription patterns and frequencies of CHPs for treating patients with hyperlipidemia in Taiwan. BACKGROUND: Traditional Chinese medicine (TCM) has become popular as a therapy for controlling symptoms in patients with hyperlipidemia. This study aimed to analyze the prescription patterns of TCM for patients with hyperlipidemia in Taiwan. METHODS: The study population was recruited from a random-sampled cohort of 1,000,000 people from the National Health Insurance Research Database between 2003 and 2009. We identified 30,784 outpatient visits related with hyperlipidemia diagnosis and collected these medical records. Association rules of data mining were conducted to explore the co-prescription patterns for Chinese herbal products (CHPs). RESULTS: The most commonly prescribed herbal formula for hyperlipidemia treatment was Xue-Fu-Zhu-Yu-Tang (16.1%), and Shan Zha (Crataegi fructus; 25.0%) was the most commonly prescribed single herb. The most commonly prescribed combination of an herbal formula and a single herb was Xue-Fu-Zhu-Yu-Tang and Dan Shen (Radix Salviae Miltiorrhizae), and the most commonly prescribed combination of couplet herbs was Dan Shen and Shan Zha. CONCLUSION: Xue-Fu-Zhu-Yu-Tang is the most frequently prescribed formula and is typically prescribed with Shan Zha, Dan Shen, and He Shou Wu for patients with hyperlipidemia. Clinical trials are warranted in future research to investigate the effects of the CHPs in terms of safety and efficacy and in particular to evaluate potential interactions with conventional treatments. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/25828254/Use_of_traditional_Chinese_medicine_in_patients_with_hyperlipidemia:_A_population_based_study_in_Taiwan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(15)00199-3 DB - PRIME DP - Unbound Medicine ER -