Tags

Type your tag names separated by a space and hit enter

Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Am J Clin Nutr 2015; 101(5):1088-96AJ

Abstract

BACKGROUND

The prevalence of type 2 diabetes (T2D) is increasing around the world. Eggs are a major source of cholesterol, which has been associated with elevated blood glucose and an increased risk of T2D. However, there are limited and conflicting data from prospective population studies on the association between egg consumption and risk of T2D.

OBJECTIVE

We investigated the association between egg consumption and risk of incident T2D in middle-aged and older men from eastern Finland.

DESIGN

The study included 2332 men aged 42-60 y in 1984-1989 at the baseline examinations of the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study. Dietary intakes were assessed with 4-d food records at baseline. Incident T2D was assessed by self-administered questionnaires; by fasting and 2-h oral-glucose-tolerance-test blood glucose measurement at re-examination rounds 4, 11, and 20 y after baseline; and by record linkage to a hospital discharge registry and reimbursement register of diabetes medication expenses. Cox proportional hazards regression analyses were used to estimate associations with the risk of incident T2D. Associations with the metabolic risk markers at baseline and at the 4-y examinations were analyzed by ANCOVA.

RESULTS

During an average follow-up of 19.3 y, 432 men developed T2D. After adjustment for potential confounders, those in the highest compared with the lowest egg intake quartile had a 38% (95% CI: 18%, 53%; P-trend across quartiles <0.001) lower risk of incident T2D. Analyses with metabolic risk markers also suggested an inverse association with fasting plasma glucose and serum C-reactive protein but not with serum insulin. The associations between cholesterol intake and risk of T2D, plasma glucose, serum insulin, and C-reactive protein were mainly nonsignificant, especially after accounting for egg consumption.

CONCLUSION

Higher egg intake was associated with a lower risk of T2D in this cohort of middle-aged and older men.

Authors+Show Affiliations

From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25832339

Citation

Virtanen, Jyrki K., et al. "Egg Consumption and Risk of Incident Type 2 Diabetes in Men: the Kuopio Ischaemic Heart Disease Risk Factor Study." The American Journal of Clinical Nutrition, vol. 101, no. 5, 2015, pp. 1088-96.
Virtanen JK, Mursu J, Tuomainen TP, et al. Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2015;101(5):1088-96.
Virtanen, J. K., Mursu, J., Tuomainen, T. P., Virtanen, H. E., & Voutilainen, S. (2015). Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American Journal of Clinical Nutrition, 101(5), pp. 1088-96. doi:10.3945/ajcn.114.104109.
Virtanen JK, et al. Egg Consumption and Risk of Incident Type 2 Diabetes in Men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2015;101(5):1088-96. PubMed PMID: 25832339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. AU - Virtanen,Jyrki K, AU - Mursu,Jaakko, AU - Tuomainen,Tomi-Pekka, AU - Virtanen,Heli Ek, AU - Voutilainen,Sari, Y1 - 2015/04/01/ PY - 2014/11/27/received PY - 2015/03/10/accepted PY - 2015/4/3/entrez PY - 2015/4/3/pubmed PY - 2015/7/29/medline KW - diet KW - eggs KW - men KW - prospective study KW - type 2 diabetes SP - 1088 EP - 96 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 101 IS - 5 N2 - BACKGROUND: The prevalence of type 2 diabetes (T2D) is increasing around the world. Eggs are a major source of cholesterol, which has been associated with elevated blood glucose and an increased risk of T2D. However, there are limited and conflicting data from prospective population studies on the association between egg consumption and risk of T2D. OBJECTIVE: We investigated the association between egg consumption and risk of incident T2D in middle-aged and older men from eastern Finland. DESIGN: The study included 2332 men aged 42-60 y in 1984-1989 at the baseline examinations of the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study. Dietary intakes were assessed with 4-d food records at baseline. Incident T2D was assessed by self-administered questionnaires; by fasting and 2-h oral-glucose-tolerance-test blood glucose measurement at re-examination rounds 4, 11, and 20 y after baseline; and by record linkage to a hospital discharge registry and reimbursement register of diabetes medication expenses. Cox proportional hazards regression analyses were used to estimate associations with the risk of incident T2D. Associations with the metabolic risk markers at baseline and at the 4-y examinations were analyzed by ANCOVA. RESULTS: During an average follow-up of 19.3 y, 432 men developed T2D. After adjustment for potential confounders, those in the highest compared with the lowest egg intake quartile had a 38% (95% CI: 18%, 53%; P-trend across quartiles <0.001) lower risk of incident T2D. Analyses with metabolic risk markers also suggested an inverse association with fasting plasma glucose and serum C-reactive protein but not with serum insulin. The associations between cholesterol intake and risk of T2D, plasma glucose, serum insulin, and C-reactive protein were mainly nonsignificant, especially after accounting for egg consumption. CONCLUSION: Higher egg intake was associated with a lower risk of T2D in this cohort of middle-aged and older men. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25832339/Egg_consumption_and_risk_of_incident_type_2_diabetes_in_men:_the_Kuopio_Ischaemic_Heart_Disease_Risk_Factor_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.104109 DB - PRIME DP - Unbound Medicine ER -