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The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial.
Am J Clin Nutr. 2015 Apr; 101(4):705-13.AJ

Abstract

BACKGROUND

Previously published research that examined the effects of high egg consumption in people with type 2 diabetes (T2D) produced conflicting results leading to recommendations to limit egg intake. However, people with T2D may benefit from egg consumption because eggs are a nutritious and convenient way of improving protein and micronutrient contents of the diet, which have importance for satiety and weight management.

OBJECTIVE

In this randomized controlled study, we aimed to determine whether a high-egg diet (2 eggs/d for 6 d/wk) compared with a low-egg diet (<2 eggs/wk) affected circulating lipid profiles, in particular high-density lipoprotein (HDL) cholesterol, in overweight or obese people with prediabetes or T2D.

DESIGN

A total of 140 participants were randomly assigned to one of the 2 diets as part of a 3-mo weight maintenance study. Participants attended the clinic monthly and were instructed on the specific types of foods and quantities to be consumed.

RESULTS

There was no significant difference in the change in HDL cholesterol from screening to 3 mo between groups; the mean difference (95% CI) between high- and low-egg groups was +0.02 mmol/L (-0.03, 0.08 mmol/L; P = 0.38). No between-group differences were shown for total cholesterol, low-density lipoprotein cholesterol, triglycerides, or glycemic control. Both groups were matched for protein intake, but the high-egg group reported less hunger and greater satiety postbreakfast. Polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA) intakes significantly increased from baseline in both groups.

CONCLUSIONS

High egg consumption did not have an adverse effect on the lipid profile of people with T2D in the context of increased MUFA and PUFA consumption. This study suggests that a high-egg diet can be included safely as part of the dietary management of T2D, and it may provide greater satiety. This trial was registered at the Australia New Zealand Clinical Trials Registry (http://www.anzctr.org.au/) as ACTRN12612001266853.

Authors+Show Affiliations

From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).From The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders (NRF, AS, IDC, GD, MF, JG, KB, KHW, NSL, and TPM) and School of Molecular Bioscience (GD), The University of Sydney, Sydney, Australia, and Metabolism & Obesity Services, Royal Prince Alfred Hospital, Camperdown, Australia (IDC and TPM).

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25833969

Citation

Fuller, Nicholas R., et al. "The Effect of a High-egg Diet On Cardiovascular Risk Factors in People With Type 2 Diabetes: the Diabetes and Egg (DIABEGG) Study-a 3-mo Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 101, no. 4, 2015, pp. 705-13.
Fuller NR, Caterson ID, Sainsbury A, et al. The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial. Am J Clin Nutr. 2015;101(4):705-13.
Fuller, N. R., Caterson, I. D., Sainsbury, A., Denyer, G., Fong, M., Gerofi, J., Baqleh, K., Williams, K. H., Lau, N. S., & Markovic, T. P. (2015). The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial. The American Journal of Clinical Nutrition, 101(4), 705-13. https://doi.org/10.3945/ajcn.114.096925
Fuller NR, et al. The Effect of a High-egg Diet On Cardiovascular Risk Factors in People With Type 2 Diabetes: the Diabetes and Egg (DIABEGG) Study-a 3-mo Randomized Controlled Trial. Am J Clin Nutr. 2015;101(4):705-13. PubMed PMID: 25833969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial. AU - Fuller,Nicholas R, AU - Caterson,Ian D, AU - Sainsbury,Amanda, AU - Denyer,Gareth, AU - Fong,Mackenzie, AU - Gerofi,James, AU - Baqleh,Katherine, AU - Williams,Kathryn H, AU - Lau,Namson S, AU - Markovic,Tania P, Y1 - 2015/02/11/ PY - 2014/07/30/received PY - 2015/01/05/accepted PY - 2015/4/3/entrez PY - 2015/4/4/pubmed PY - 2015/6/4/medline KW - cardiovascular disease KW - cholesterol KW - high-density lipoprotein KW - lipids KW - obesity SP - 705 EP - 13 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 101 IS - 4 N2 - BACKGROUND: Previously published research that examined the effects of high egg consumption in people with type 2 diabetes (T2D) produced conflicting results leading to recommendations to limit egg intake. However, people with T2D may benefit from egg consumption because eggs are a nutritious and convenient way of improving protein and micronutrient contents of the diet, which have importance for satiety and weight management. OBJECTIVE: In this randomized controlled study, we aimed to determine whether a high-egg diet (2 eggs/d for 6 d/wk) compared with a low-egg diet (<2 eggs/wk) affected circulating lipid profiles, in particular high-density lipoprotein (HDL) cholesterol, in overweight or obese people with prediabetes or T2D. DESIGN: A total of 140 participants were randomly assigned to one of the 2 diets as part of a 3-mo weight maintenance study. Participants attended the clinic monthly and were instructed on the specific types of foods and quantities to be consumed. RESULTS: There was no significant difference in the change in HDL cholesterol from screening to 3 mo between groups; the mean difference (95% CI) between high- and low-egg groups was +0.02 mmol/L (-0.03, 0.08 mmol/L; P = 0.38). No between-group differences were shown for total cholesterol, low-density lipoprotein cholesterol, triglycerides, or glycemic control. Both groups were matched for protein intake, but the high-egg group reported less hunger and greater satiety postbreakfast. Polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA) intakes significantly increased from baseline in both groups. CONCLUSIONS: High egg consumption did not have an adverse effect on the lipid profile of people with T2D in the context of increased MUFA and PUFA consumption. This study suggests that a high-egg diet can be included safely as part of the dietary management of T2D, and it may provide greater satiety. This trial was registered at the Australia New Zealand Clinical Trials Registry (http://www.anzctr.org.au/) as ACTRN12612001266853. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25833969/The_effect_of_a_high_egg_diet_on_cardiovascular_risk_factors_in_people_with_type_2_diabetes:_the_Diabetes_and_Egg__DIABEGG__study_a_3_mo_randomized_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.096925 DB - PRIME DP - Unbound Medicine ER -