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Dietary patterns and breast cancer risk: a study in 2 cohorts.

Abstract

BACKGROUND

Evidence for a role of dietary risk factors in the cause of breast cancer has been inconsistent. The evaluation of overall dietary patterns instead of foods in isolation may better reflect the nature of true dietary exposure in a population.

OBJECTIVE

We used 2 cohort studies to identify and confirm associations between dietary patterns and breast cancer risk.

DESIGN

Dietary patterns were derived by using a principal components factor analysis in 1097 breast cancer cases and an age-stratified subcohort of 3320 women sampled from 39,532 female participants in the Canadian Study of Diet, Lifestyle and Health (CSDLH). We conducted a confirmatory factor analysis in 49,410 subjects in the National Breast Screening Study (NBSS) in whom 3659 cases of incident breast cancer developed. Cox regression models were used to estimate HRs for the association between derived dietary factors and risk of breast cancer in both cohorts.

RESULTS

The following 3 dietary factors were identified from the CSDLH: healthy, ethnic, and meat and potatoes. In the CSDLH, the healthy dietary pattern was associated with reduced risk of breast cancer (HR for high compared with low quintiles: 0.73; 95% CI: 0.58, 0.91; P-trend = 0.001), and the meat and potatoes dietary pattern was associated with increased risk in postmenopausal women only (HR for high compared with low quintiles: 1.26; 95% CI: 0.92, 1.73; P-trend = 0.043). In the NBSS, the association between the meat and potatoes pattern and postmenopausal breast cancer risk was confirmed (HR: 1.31; 95% CI: 0.98, 1.76; P-trend = 0.043), but there was no association between the healthy pattern and risk of breast cancer.

CONCLUSION

Adherence to a plant-based diet that limits red meat intake may be associated with reduced risk of breast cancer, particularly in postmenopausal women.

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  • Authors+Show Affiliations

    ,

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    ,

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    ,

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    ,

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    ,

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (CC, RSK, and TER); Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada (VAK and NK); the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (VAK and NK); the University of Alberta, Edmonton, Canada (CLS); and the Faculty of Health, University of Canberra, Canberra, Australia (CLS).

    Source

    MeSH

    Aged
    Body Mass Index
    Breast Neoplasms
    Canada
    Cohort Studies
    Diet
    Diet, Vegetarian
    Energy Intake
    Feeding Behavior
    Female
    Humans
    Life Style
    Meat
    Middle Aged
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Solanum tuberosum
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25833979

    Citation

    Catsburg, Chelsea, et al. "Dietary Patterns and Breast Cancer Risk: a Study in 2 Cohorts." The American Journal of Clinical Nutrition, vol. 101, no. 4, 2015, pp. 817-23.
    Catsburg C, Kim RS, Kirsh VA, et al. Dietary patterns and breast cancer risk: a study in 2 cohorts. Am J Clin Nutr. 2015;101(4):817-23.
    Catsburg, C., Kim, R. S., Kirsh, V. A., Soskolne, C. L., Kreiger, N., & Rohan, T. E. (2015). Dietary patterns and breast cancer risk: a study in 2 cohorts. The American Journal of Clinical Nutrition, 101(4), pp. 817-23. doi:10.3945/ajcn.114.097659.
    Catsburg C, et al. Dietary Patterns and Breast Cancer Risk: a Study in 2 Cohorts. Am J Clin Nutr. 2015;101(4):817-23. PubMed PMID: 25833979.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary patterns and breast cancer risk: a study in 2 cohorts. AU - Catsburg,Chelsea, AU - Kim,Ryung S, AU - Kirsh,Victoria A, AU - Soskolne,Colin L, AU - Kreiger,Nancy, AU - Rohan,Thomas E, Y1 - 2015/02/11/ PY - 2014/08/14/received PY - 2015/01/12/accepted PY - 2015/4/3/entrez PY - 2015/4/4/pubmed PY - 2015/6/4/medline KW - PCFA KW - breast cancer KW - cohort KW - dietary patterns KW - epidemiology SP - 817 EP - 23 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 101 IS - 4 N2 - BACKGROUND: Evidence for a role of dietary risk factors in the cause of breast cancer has been inconsistent. The evaluation of overall dietary patterns instead of foods in isolation may better reflect the nature of true dietary exposure in a population. OBJECTIVE: We used 2 cohort studies to identify and confirm associations between dietary patterns and breast cancer risk. DESIGN: Dietary patterns were derived by using a principal components factor analysis in 1097 breast cancer cases and an age-stratified subcohort of 3320 women sampled from 39,532 female participants in the Canadian Study of Diet, Lifestyle and Health (CSDLH). We conducted a confirmatory factor analysis in 49,410 subjects in the National Breast Screening Study (NBSS) in whom 3659 cases of incident breast cancer developed. Cox regression models were used to estimate HRs for the association between derived dietary factors and risk of breast cancer in both cohorts. RESULTS: The following 3 dietary factors were identified from the CSDLH: healthy, ethnic, and meat and potatoes. In the CSDLH, the healthy dietary pattern was associated with reduced risk of breast cancer (HR for high compared with low quintiles: 0.73; 95% CI: 0.58, 0.91; P-trend = 0.001), and the meat and potatoes dietary pattern was associated with increased risk in postmenopausal women only (HR for high compared with low quintiles: 1.26; 95% CI: 0.92, 1.73; P-trend = 0.043). In the NBSS, the association between the meat and potatoes pattern and postmenopausal breast cancer risk was confirmed (HR: 1.31; 95% CI: 0.98, 1.76; P-trend = 0.043), but there was no association between the healthy pattern and risk of breast cancer. CONCLUSION: Adherence to a plant-based diet that limits red meat intake may be associated with reduced risk of breast cancer, particularly in postmenopausal women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25833979/Dietary_patterns_and_breast_cancer_risk:_a_study_in_2_cohorts_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.097659 DB - PRIME DP - Unbound Medicine ER -