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The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats.
Neuropsychopharmacology. 2015 Sep; 40(10):2425-33.N

Abstract

Prior studies suggest that the insular cortex (IC), and particularly its posterior region (the PIc), is involved in nicotine craving and relapse in humans and rodents. The present experiments were conducted to determine whether the IC and its different subregions regulate relapse to cocaine-seeking behavior in rats. To address this issue, male Sprague-Dawley rats underwent cocaine self-administration followed by extinction training and reinstatement tests. Before each reinstatement, the PIc or the more anterior dorsal agranular IC (AId) was inactivated to determine their roles in the reinstatement to cocaine seeking. In contrast to the nicotine findings, PIc inactivation had no effect on cue-induced reinstatement for cocaine seeking. However, AId inactivation reduced cued reinstatement while having no effect on cocaine-prime reinstatement. AId inactivation had no effect on reinstatement of food-seeking behavior induced by cues, a food-prime, or cues+food-prime. Based on previous work hypothesizing a role for corticotropin-releasing factor (CRF) in the IC during craving and relapse, a subsequent experiment found that CRF receptor-1 (CRF1) blockade in the AId similarly reduced cued reinstatement. Our results suggest that the AId, along with CRF1 receptors in this region, regulates reinstatement to cocaine seeking, but not food seeking, depending on the type of reinstatement, whereas PIc activity does not influence cue-induced reinstatement.

Authors+Show Affiliations

Department of Psychology, University of Iowa, Iowa City, IA, USA.Department of Psychology, University of Iowa, Iowa City, IA, USA.1] Department of Psychology, University of Iowa, Iowa City, IA, USA [2] Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25837282

Citation

Cosme, Caitlin V., et al. "The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but Not Food-Seeking, Behavior in Rats." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 40, no. 10, 2015, pp. 2425-33.
Cosme CV, Gutman AL, LaLumiere RT. The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats. Neuropsychopharmacology. 2015;40(10):2425-33.
Cosme, C. V., Gutman, A. L., & LaLumiere, R. T. (2015). The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(10), 2425-33. https://doi.org/10.1038/npp.2015.92
Cosme CV, Gutman AL, LaLumiere RT. The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but Not Food-Seeking, Behavior in Rats. Neuropsychopharmacology. 2015;40(10):2425-33. PubMed PMID: 25837282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats. AU - Cosme,Caitlin V, AU - Gutman,Andrea L, AU - LaLumiere,Ryan T, Y1 - 2015/04/03/ PY - 2014/08/12/received PY - 2015/03/16/revised PY - 2015/03/19/accepted PY - 2015/4/4/entrez PY - 2015/4/4/pubmed PY - 2016/5/10/medline SP - 2425 EP - 33 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 40 IS - 10 N2 - Prior studies suggest that the insular cortex (IC), and particularly its posterior region (the PIc), is involved in nicotine craving and relapse in humans and rodents. The present experiments were conducted to determine whether the IC and its different subregions regulate relapse to cocaine-seeking behavior in rats. To address this issue, male Sprague-Dawley rats underwent cocaine self-administration followed by extinction training and reinstatement tests. Before each reinstatement, the PIc or the more anterior dorsal agranular IC (AId) was inactivated to determine their roles in the reinstatement to cocaine seeking. In contrast to the nicotine findings, PIc inactivation had no effect on cue-induced reinstatement for cocaine seeking. However, AId inactivation reduced cued reinstatement while having no effect on cocaine-prime reinstatement. AId inactivation had no effect on reinstatement of food-seeking behavior induced by cues, a food-prime, or cues+food-prime. Based on previous work hypothesizing a role for corticotropin-releasing factor (CRF) in the IC during craving and relapse, a subsequent experiment found that CRF receptor-1 (CRF1) blockade in the AId similarly reduced cued reinstatement. Our results suggest that the AId, along with CRF1 receptors in this region, regulates reinstatement to cocaine seeking, but not food seeking, depending on the type of reinstatement, whereas PIc activity does not influence cue-induced reinstatement. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/25837282/The_Dorsal_Agranular_Insular_Cortex_Regulates_the_Cued_Reinstatement_of_Cocaine_Seeking_but_not_Food_Seeking_Behavior_in_Rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25837282/ DB - PRIME DP - Unbound Medicine ER -