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Combined conjunctival rotational autograft with 0.02% mitomycin C in primary pterygium surgery: a long-term follow-up study.
Br J Ophthalmol. 2015 Oct; 99(10):1396-400.BJ

Abstract

BACKGROUND/AIMS

To compare the long-term outcomes of primary pterygium surgery with combined conjunctival rotational autograft and mitomycin C (CRA-MMC), mitomycin C alone (MMC) and limbal conjunctival autograft (LCAU).

METHODS

The outcomes of primary pterygium excision followed by conjunctival rotational autograft (CRA) combined with intraoperative 0.02% MMC for 5 min (group 1, CRA-MMC, n=61) were compared with historical control groups consisting of, pterygium excision with MMC (group 2, n=47), and, pterygium excision with limbal conjunctival autograft (LCAU) (group 3, n=29). The main outcome measures were recurrence rate and complications.

RESULTS

The mean follow-up period was 101±3 months, 138±2 and 137±2 months in the CRA-MMC, MMC and LCAU groups respectively. Recurrence was noted in one patient (1.6%) in the CRA-MMC, 12 patients with MMC (25.5%) and 2 patients with LCAU (6.9%). The difference in recurrence rate between CRA-MMC and MMC was statistically significant (p<0.001). Early postoperative complications included 3 conjunctival cysts (1 from the CRA-MMC, 2 with MMC alone), 2 symblephara (1 in the MMC group, 1 in the LCAU group), and 1 granuloma in the CRA-MMC group.

CONCLUSIONS

Pterygium excision followed by CRA-MMC or LCAU are effective means of preventing recurrence. The use of CRA-MMC in pterygium excision may be considered for cases where conventional autograft harvesting is contraindicated or when large grafts for double-head pterygium are required.

Authors+Show Affiliations

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, Shatin, Hong Kong.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, Shatin, Hong Kong.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, Shatin, Hong Kong.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, Shatin, Hong Kong.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, Shatin, Hong Kong.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25837606

Citation

Tsim, Nicole C., et al. "Combined Conjunctival Rotational Autograft With 0.02% Mitomycin C in Primary Pterygium Surgery: a Long-term Follow-up Study." The British Journal of Ophthalmology, vol. 99, no. 10, 2015, pp. 1396-400.
Tsim NC, Young AL, Jhanji V, et al. Combined conjunctival rotational autograft with 0.02% mitomycin C in primary pterygium surgery: a long-term follow-up study. Br J Ophthalmol. 2015;99(10):1396-400.
Tsim, N. C., Young, A. L., Jhanji, V., Ho, M., & Cheng, L. L. (2015). Combined conjunctival rotational autograft with 0.02% mitomycin C in primary pterygium surgery: a long-term follow-up study. The British Journal of Ophthalmology, 99(10), 1396-400. https://doi.org/10.1136/bjophthalmol-2014-305817
Tsim NC, et al. Combined Conjunctival Rotational Autograft With 0.02% Mitomycin C in Primary Pterygium Surgery: a Long-term Follow-up Study. Br J Ophthalmol. 2015;99(10):1396-400. PubMed PMID: 25837606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined conjunctival rotational autograft with 0.02% mitomycin C in primary pterygium surgery: a long-term follow-up study. AU - Tsim,Nicole C, AU - Young,Alvin L, AU - Jhanji,Vishal, AU - Ho,Mary, AU - Cheng,Lulu L, Y1 - 2015/04/02/ PY - 2014/09/28/received PY - 2015/03/14/accepted PY - 2015/4/4/entrez PY - 2015/4/4/pubmed PY - 2015/12/19/medline KW - Cornea KW - Degeneration KW - Treatment Surgery SP - 1396 EP - 400 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 99 IS - 10 N2 - BACKGROUND/AIMS: To compare the long-term outcomes of primary pterygium surgery with combined conjunctival rotational autograft and mitomycin C (CRA-MMC), mitomycin C alone (MMC) and limbal conjunctival autograft (LCAU). METHODS: The outcomes of primary pterygium excision followed by conjunctival rotational autograft (CRA) combined with intraoperative 0.02% MMC for 5 min (group 1, CRA-MMC, n=61) were compared with historical control groups consisting of, pterygium excision with MMC (group 2, n=47), and, pterygium excision with limbal conjunctival autograft (LCAU) (group 3, n=29). The main outcome measures were recurrence rate and complications. RESULTS: The mean follow-up period was 101±3 months, 138±2 and 137±2 months in the CRA-MMC, MMC and LCAU groups respectively. Recurrence was noted in one patient (1.6%) in the CRA-MMC, 12 patients with MMC (25.5%) and 2 patients with LCAU (6.9%). The difference in recurrence rate between CRA-MMC and MMC was statistically significant (p<0.001). Early postoperative complications included 3 conjunctival cysts (1 from the CRA-MMC, 2 with MMC alone), 2 symblephara (1 in the MMC group, 1 in the LCAU group), and 1 granuloma in the CRA-MMC group. CONCLUSIONS: Pterygium excision followed by CRA-MMC or LCAU are effective means of preventing recurrence. The use of CRA-MMC in pterygium excision may be considered for cases where conventional autograft harvesting is contraindicated or when large grafts for double-head pterygium are required. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/25837606/Combined_conjunctival_rotational_autograft_with_0_02_mitomycin_C_in_primary_pterygium_surgery:_a_long_term_follow_up_study_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&amp;pmid=25837606 DB - PRIME DP - Unbound Medicine ER -