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Possible salivary and serum biomarkers for oral lichen planus.
Biotech Histochem. 2015; 90(7):552-8.BH

Abstract

There are few reports concerning the potential for clinical application of oxidative stress (OS) and collagen degradation markers in oral lichen planus (OLP) patients. We investigated the possibility of using some disease-related biomarkers in saliva and serum of OLP patients. Our study included 30 patients with OLP and 30 controls. We evaluated serum and salivary OS biomarkers including 8-OHdG, MDA, uric acid, TAC and GPx. We also investigated collagen degradation markers such as CTX I and MMP-8. We found significantly increased salivary levels of MMP-8 and CTX I in the OLP group compared to controls and significant differences between the OLP and control groups in serum and saliva for 8-OHdG, MDA (significantly increased), uric acid, TAC and GPx (significantly reduced). Currently there are no criteria for evaluating which OLP patients have a greater risk of malignant transformation. In addition to clinical surveillance, the serum and salivary biomarkers that we evaluated may be useful biomarkers for monitoring OLP patients in the future.

Authors+Show Affiliations

a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.b Oral Pathology Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25839238

Citation

Totan, A, et al. "Possible Salivary and Serum Biomarkers for Oral Lichen Planus." Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission, vol. 90, no. 7, 2015, pp. 552-8.
Totan A, Miricescu D, Parlatescu I, et al. Possible salivary and serum biomarkers for oral lichen planus. Biotech Histochem. 2015;90(7):552-8.
Totan, A., Miricescu, D., Parlatescu, I., Mohora, M., & Greabu, M. (2015). Possible salivary and serum biomarkers for oral lichen planus. Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission, 90(7), 552-8. https://doi.org/10.3109/10520295.2015.1016115
Totan A, et al. Possible Salivary and Serum Biomarkers for Oral Lichen Planus. Biotech Histochem. 2015;90(7):552-8. PubMed PMID: 25839238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible salivary and serum biomarkers for oral lichen planus. AU - Totan,A, AU - Miricescu,D, AU - Parlatescu,I, AU - Mohora,M, AU - Greabu,M, Y1 - 2015/04/03/ PY - 2015/4/4/entrez PY - 2015/4/4/pubmed PY - 2016/9/2/medline KW - oral lichen planus KW - oxidative stress KW - saliva SP - 552 EP - 8 JF - Biotechnic & histochemistry : official publication of the Biological Stain Commission JO - Biotech Histochem VL - 90 IS - 7 N2 - There are few reports concerning the potential for clinical application of oxidative stress (OS) and collagen degradation markers in oral lichen planus (OLP) patients. We investigated the possibility of using some disease-related biomarkers in saliva and serum of OLP patients. Our study included 30 patients with OLP and 30 controls. We evaluated serum and salivary OS biomarkers including 8-OHdG, MDA, uric acid, TAC and GPx. We also investigated collagen degradation markers such as CTX I and MMP-8. We found significantly increased salivary levels of MMP-8 and CTX I in the OLP group compared to controls and significant differences between the OLP and control groups in serum and saliva for 8-OHdG, MDA (significantly increased), uric acid, TAC and GPx (significantly reduced). Currently there are no criteria for evaluating which OLP patients have a greater risk of malignant transformation. In addition to clinical surveillance, the serum and salivary biomarkers that we evaluated may be useful biomarkers for monitoring OLP patients in the future. SN - 1473-7760 UR - https://www.unboundmedicine.com/medline/citation/25839238/Possible_salivary_and_serum_biomarkers_for_oral_lichen_planus_ L2 - https://www.tandfonline.com/doi/full/10.3109/10520295.2015.1016115 DB - PRIME DP - Unbound Medicine ER -