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White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate.
J Nutr Biochem. 2015 Jul; 26(7):752-60.JN

Abstract

Common beans are a rich source of nondigestible fermentable components and phenolic compounds that have anti-inflammatory effects. We assessed the gut-health-promoting potential of kidney beans in healthy mice and their ability to attenuate colonic inflammation following dextran sodium sulphate (DSS) exposure (via drinking water, 2% DSS w/v, 7 days). C57BL/6 mice were fed one of three isocaloric diets: basal diet control (BD), or BD supplemented with 20% cooked white (WK) or dark red kidney (DK) bean flour for 3 weeks. In healthy mice, anti-inflammatory microbial-derived cecal short chain fatty acid (SCFA) levels (acetate, butyrate and propionate), colon crypt height and colonic Mucin 1 (MUC1) and Resistin-like Molecule beta (Relmβ) mRNA expression all increased in WK- and DK-fed mice compared to BD, indicative of enhanced microbial activity, gut barrier integrity and antimicrobial defense response. During colitis, both bean diets reduced (a) disease severity, (b) colonic histological damage and (c) increased mRNA expression of antimicrobial and barrier integrity-promoting genes (Toll-like Receptor 4 (TLR4), MUC1-3, Relmβ and Trefoil Factor 3 (TFF3)) and reduced proinflammatory mediator expression [interleukin (IL)-1β, IL-6, interferon (IFN)γ, tumor necrosis factor (TNF)α and monocyte chemoattractant protein-1], which correlated with reduced colon tissue protein levels. Further, bean diets exerted a systemic anti-inflammatory effect during colitis by reducing serum levels of IL-17A, IFNγ, TNFα, IL-1β and IL-6. In conclusion, both WK and DK bean-supplemented diets enhanced microbial-derived SCFA metabolite production, gut barrier integrity and the microbial defensive response in the healthy colon, which supported an anti-inflammatory phenotype during colitis. Collectively, these data demonstrate a beneficial colon-function priming effect of bean consumption that mitigates colitis severity.

Authors+Show Affiliations

Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9.Department of Plant Agriculture, University of Guelph, Guelph ON, Canada, N1G 2W1.Department of Pathobiology, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9.Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1.Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph ON, Canada, N1G 5C9; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada, N1G 2W1. Electronic address: krista.power@agr.gc.ca.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25841250

Citation

Monk, Jennifer M., et al. "White and Dark Kidney Beans Reduce Colonic Mucosal Damage and Inflammation in Response to Dextran Sodium Sulfate." The Journal of Nutritional Biochemistry, vol. 26, no. 7, 2015, pp. 752-60.
Monk JM, Zhang CP, Wu W, et al. White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate. J Nutr Biochem. 2015;26(7):752-60.
Monk, J. M., Zhang, C. P., Wu, W., Zarepoor, L., Lu, J. T., Liu, R., Pauls, K. P., Wood, G. A., Tsao, R., Robinson, L. E., & Power, K. A. (2015). White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate. The Journal of Nutritional Biochemistry, 26(7), 752-60. https://doi.org/10.1016/j.jnutbio.2015.02.003
Monk JM, et al. White and Dark Kidney Beans Reduce Colonic Mucosal Damage and Inflammation in Response to Dextran Sodium Sulfate. J Nutr Biochem. 2015;26(7):752-60. PubMed PMID: 25841250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate. AU - Monk,Jennifer M, AU - Zhang,Claire P, AU - Wu,Wenqing, AU - Zarepoor,Leila, AU - Lu,Jenifer T, AU - Liu,Ronghua, AU - Pauls,K Peter, AU - Wood,Geoffrey A, AU - Tsao,Rong, AU - Robinson,Lindsay E, AU - Power,Krista A, Y1 - 2015/03/21/ PY - 2014/07/08/received PY - 2014/12/17/revised PY - 2015/02/06/accepted PY - 2015/4/6/entrez PY - 2015/4/7/pubmed PY - 2016/3/10/medline KW - Colitis KW - Colon health KW - Dextran sodium sulfate KW - Inflammation KW - Kidney beans KW - Short-chain fatty acids SP - 752 EP - 60 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 26 IS - 7 N2 - Common beans are a rich source of nondigestible fermentable components and phenolic compounds that have anti-inflammatory effects. We assessed the gut-health-promoting potential of kidney beans in healthy mice and their ability to attenuate colonic inflammation following dextran sodium sulphate (DSS) exposure (via drinking water, 2% DSS w/v, 7 days). C57BL/6 mice were fed one of three isocaloric diets: basal diet control (BD), or BD supplemented with 20% cooked white (WK) or dark red kidney (DK) bean flour for 3 weeks. In healthy mice, anti-inflammatory microbial-derived cecal short chain fatty acid (SCFA) levels (acetate, butyrate and propionate), colon crypt height and colonic Mucin 1 (MUC1) and Resistin-like Molecule beta (Relmβ) mRNA expression all increased in WK- and DK-fed mice compared to BD, indicative of enhanced microbial activity, gut barrier integrity and antimicrobial defense response. During colitis, both bean diets reduced (a) disease severity, (b) colonic histological damage and (c) increased mRNA expression of antimicrobial and barrier integrity-promoting genes (Toll-like Receptor 4 (TLR4), MUC1-3, Relmβ and Trefoil Factor 3 (TFF3)) and reduced proinflammatory mediator expression [interleukin (IL)-1β, IL-6, interferon (IFN)γ, tumor necrosis factor (TNF)α and monocyte chemoattractant protein-1], which correlated with reduced colon tissue protein levels. Further, bean diets exerted a systemic anti-inflammatory effect during colitis by reducing serum levels of IL-17A, IFNγ, TNFα, IL-1β and IL-6. In conclusion, both WK and DK bean-supplemented diets enhanced microbial-derived SCFA metabolite production, gut barrier integrity and the microbial defensive response in the healthy colon, which supported an anti-inflammatory phenotype during colitis. Collectively, these data demonstrate a beneficial colon-function priming effect of bean consumption that mitigates colitis severity. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/25841250/White_and_dark_kidney_beans_reduce_colonic_mucosal_damage_and_inflammation_in_response_to_dextran_sodium_sulfate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(15)00059-5 DB - PRIME DP - Unbound Medicine ER -