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Anaphylaxis to the carbohydrate side chain alpha-gal.
Immunol Allergy Clin North Am 2015; 35(2):247-60IA

Abstract

In 2007, the monoclonal antibody cetuximab caused severe hypersensitivity reactions during the first infusion in a region of the southeastern United States. Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is present on the Fab of cetuximab. Alpha-gal is a blood group substance of nonprimate mammals. These IgE antibodies are also associated with delayed anaphylaxis to red meat (ie, to meat or organs of animals that carry this oligosaccharide). Evidence shows that the primary cause of these IgE antibodies is bites from the tick Amblyomma americanum or its larvae.

Authors+Show Affiliations

Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA. Electronic address: tap2z@virginia.edu.Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA.Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA.Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25841549

Citation

Platts-Mills, Thomas A E., et al. "Anaphylaxis to the Carbohydrate Side Chain Alpha-gal." Immunology and Allergy Clinics of North America, vol. 35, no. 2, 2015, pp. 247-60.
Platts-Mills TA, Schuyler AJ, Tripathi A, et al. Anaphylaxis to the carbohydrate side chain alpha-gal. Immunol Allergy Clin North Am. 2015;35(2):247-60.
Platts-Mills, T. A., Schuyler, A. J., Tripathi, A., & Commins, S. P. (2015). Anaphylaxis to the carbohydrate side chain alpha-gal. Immunology and Allergy Clinics of North America, 35(2), pp. 247-60. doi:10.1016/j.iac.2015.01.009.
Platts-Mills TA, et al. Anaphylaxis to the Carbohydrate Side Chain Alpha-gal. Immunol Allergy Clin North Am. 2015;35(2):247-60. PubMed PMID: 25841549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaphylaxis to the carbohydrate side chain alpha-gal. AU - Platts-Mills,Thomas A E, AU - Schuyler,Alexander J, AU - Tripathi,Anubha, AU - Commins,Scott P, Y1 - 2015/03/06/ PY - 2015/4/6/entrez PY - 2015/4/7/pubmed PY - 2015/12/19/medline KW - Alpha-gal KW - Cetuximab KW - Delayed anaphylaxis KW - Red-meat allergy KW - Ticks SP - 247 EP - 60 JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 35 IS - 2 N2 - In 2007, the monoclonal antibody cetuximab caused severe hypersensitivity reactions during the first infusion in a region of the southeastern United States. Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is present on the Fab of cetuximab. Alpha-gal is a blood group substance of nonprimate mammals. These IgE antibodies are also associated with delayed anaphylaxis to red meat (ie, to meat or organs of animals that carry this oligosaccharide). Evidence shows that the primary cause of these IgE antibodies is bites from the tick Amblyomma americanum or its larvae. SN - 1557-8607 UR - https://www.unboundmedicine.com/medline/citation/25841549/Anaphylaxis_to_the_carbohydrate_side_chain_alpha_gal_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8561(15)00010-7 DB - PRIME DP - Unbound Medicine ER -