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Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma.
Int Immunopharmacol 2015; 26(1):237-45II

Abstract

Oxidant-antioxidant imbalance plays an important role in repeated cycles of airway inflammation observed in asthma. It is when reactive oxygen species (ROS) overwhelm antioxidant defenses that a severe inflammatory state becomes apparent and may impact vasculature. Several studies have shown an association between airway inflammation and cardiovascular complications; however so far none has investigated the link between airway oxidative stress and systemic/vascular oxidative stress in a murine model of asthma. Therefore, this study investigated the contribution of oxidative stress encountered in asthmatic airways in modulation of vascular/systemic oxidant-antioxidant balance. Rats were sensitized intraperitoneally with ovalbumin (OVA) in the presence of aluminum hydroxide followed by several intranasal (i.n.) challenges with OVA. Rats were then assessed for airway and vascular inflammation, oxidative stress (ROS, lipid peroxides) and antioxidants measured as total antioxidant capacity (TAC) and thiol content. Challenge with OVA led to increased airway inflammation and oxidative stress with a concomitant increase in vascular inflammation and oxidative stress. Oxidative stress in the vasculature was significantly inhibited by antioxidant treatment, N-acetyl cysteine; whereas hydrogen peroxide (H2O2) inhalation worsened it. Therefore, our study shows that oxidative airway inflammation is associated with vascular/systemic oxidative stress which might predispose these patients to increased cardiovascular risk.

Authors+Show Affiliations

Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: anadeem@ksu.edu.sa.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina, Saudi Arabia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25843257

Citation

Al-Harbi, Naif O., et al. "Oxidative Airway Inflammation Leads to Systemic and Vascular Oxidative Stress in a Murine Model of Allergic Asthma." International Immunopharmacology, vol. 26, no. 1, 2015, pp. 237-45.
Al-Harbi NO, Nadeem A, Al-Harbi MM, et al. Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. Int Immunopharmacol. 2015;26(1):237-45.
Al-Harbi, N. O., Nadeem, A., Al-Harbi, M. M., Imam, F., Al-Shabanah, O. A., Ahmad, S. F., ... Bahashwan, S. A. (2015). Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. International Immunopharmacology, 26(1), pp. 237-45. doi:10.1016/j.intimp.2015.03.032.
Al-Harbi NO, et al. Oxidative Airway Inflammation Leads to Systemic and Vascular Oxidative Stress in a Murine Model of Allergic Asthma. Int Immunopharmacol. 2015;26(1):237-45. PubMed PMID: 25843257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. AU - Al-Harbi,Naif O, AU - Nadeem,A, AU - Al-Harbi,Mohamed M, AU - Imam,F, AU - Al-Shabanah,Othman A, AU - Ahmad,Sheikh F, AU - Sayed-Ahmed,Mohamed M, AU - Bahashwan,Saleh A, Y1 - 2015/04/03/ PY - 2015/01/19/received PY - 2015/03/24/revised PY - 2015/03/24/accepted PY - 2015/4/7/entrez PY - 2015/4/7/pubmed PY - 2016/2/18/medline KW - Airway inflammation KW - Allergens KW - Antioxidants KW - Aorta KW - Blood KW - Oxidative stress SP - 237 EP - 45 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 26 IS - 1 N2 - Oxidant-antioxidant imbalance plays an important role in repeated cycles of airway inflammation observed in asthma. It is when reactive oxygen species (ROS) overwhelm antioxidant defenses that a severe inflammatory state becomes apparent and may impact vasculature. Several studies have shown an association between airway inflammation and cardiovascular complications; however so far none has investigated the link between airway oxidative stress and systemic/vascular oxidative stress in a murine model of asthma. Therefore, this study investigated the contribution of oxidative stress encountered in asthmatic airways in modulation of vascular/systemic oxidant-antioxidant balance. Rats were sensitized intraperitoneally with ovalbumin (OVA) in the presence of aluminum hydroxide followed by several intranasal (i.n.) challenges with OVA. Rats were then assessed for airway and vascular inflammation, oxidative stress (ROS, lipid peroxides) and antioxidants measured as total antioxidant capacity (TAC) and thiol content. Challenge with OVA led to increased airway inflammation and oxidative stress with a concomitant increase in vascular inflammation and oxidative stress. Oxidative stress in the vasculature was significantly inhibited by antioxidant treatment, N-acetyl cysteine; whereas hydrogen peroxide (H2O2) inhalation worsened it. Therefore, our study shows that oxidative airway inflammation is associated with vascular/systemic oxidative stress which might predispose these patients to increased cardiovascular risk. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/25843257/Oxidative_airway_inflammation_leads_to_systemic_and_vascular_oxidative_stress_in_a_murine_model_of_allergic_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(15)00134-4 DB - PRIME DP - Unbound Medicine ER -