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Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties.
Carbohydr Polym. 2015 Jun 05; 123:39-45.CP

Abstract

We propose a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce CHT/BG-NPs scaffolds that combine the shape memory properties of chitosan and the biomineralization ability of BG-NPs for applications in bone regeneration. The addition of BG-NPs prepared by a sol-gel route to the CHT polymeric matrix improved the bioactivity of the nanocomposite scaffold, as seen by the precipitation of bone-like apatite layer upon immersion in simulated body fluid (SBF). Shape memory tests were carried out while the samples were immersed in varying compositions of water/ethanol mixtures. Dehydration with ethanol enables to fix a temporary shape of a deformed scaffold that recovers the initial geometry upon water uptake. The scaffolds present good shape memory properties characterized by a recovery ratio of 87.5% for CHT and 89.9% for CHT/BG-NPs and a fixity ratio of 97.2% for CHT and 98.2% for CHT/BG-NPs (for 30% compressive deformation). The applicability of such structures was demonstrated by a good geometrical accommodation of a previously compressed scaffold in a bone defect. The results indicate that the developed CHT/BG-NPs nanocomposite scaffolds have potential for being applied in bone tissue engineering.

Authors+Show Affiliations

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: jmano@dep.uminho.pt.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25843832

Citation

Correia, Cristina O., et al. "Chitosan/bioactive Glass Nanoparticles Scaffolds With Shape Memory Properties." Carbohydrate Polymers, vol. 123, 2015, pp. 39-45.
Correia CO, Leite ÁJ, Mano JF. Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties. Carbohydr Polym. 2015;123:39-45.
Correia, C. O., Leite, Á. J., & Mano, J. F. (2015). Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties. Carbohydrate Polymers, 123, 39-45. https://doi.org/10.1016/j.carbpol.2014.12.076
Correia CO, Leite ÁJ, Mano JF. Chitosan/bioactive Glass Nanoparticles Scaffolds With Shape Memory Properties. Carbohydr Polym. 2015 Jun 5;123:39-45. PubMed PMID: 25843832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties. AU - Correia,Cristina O, AU - Leite,Álvaro J, AU - Mano,João F, Y1 - 2015/01/13/ PY - 2014/01/15/received PY - 2014/10/27/revised PY - 2014/12/30/accepted PY - 2015/4/7/entrez PY - 2015/4/7/pubmed PY - 2016/1/5/medline KW - Bioactive glass nanoparticles KW - Bioactivity KW - Biomimetic KW - Chitosan KW - Hydromechanical cyclic test KW - Shape memory SP - 39 EP - 45 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 123 N2 - We propose a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce CHT/BG-NPs scaffolds that combine the shape memory properties of chitosan and the biomineralization ability of BG-NPs for applications in bone regeneration. The addition of BG-NPs prepared by a sol-gel route to the CHT polymeric matrix improved the bioactivity of the nanocomposite scaffold, as seen by the precipitation of bone-like apatite layer upon immersion in simulated body fluid (SBF). Shape memory tests were carried out while the samples were immersed in varying compositions of water/ethanol mixtures. Dehydration with ethanol enables to fix a temporary shape of a deformed scaffold that recovers the initial geometry upon water uptake. The scaffolds present good shape memory properties characterized by a recovery ratio of 87.5% for CHT and 89.9% for CHT/BG-NPs and a fixity ratio of 97.2% for CHT and 98.2% for CHT/BG-NPs (for 30% compressive deformation). The applicability of such structures was demonstrated by a good geometrical accommodation of a previously compressed scaffold in a bone defect. The results indicate that the developed CHT/BG-NPs nanocomposite scaffolds have potential for being applied in bone tissue engineering. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/25843832/Chitosan/bioactive_glass_nanoparticles_scaffolds_with_shape_memory_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(15)00021-1 DB - PRIME DP - Unbound Medicine ER -