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Vascular-targeted photodynamic therapy in the treatment of neovascular age-related macular degeneration: Clinical perspectives.
Photodiagnosis Photodyn Ther. 2015 Jun; 12(2):161-75.PP

Abstract

Vascular targeted photodynamic therapy (VTP), with use of verteporfin as a photosensitizer is one of the few therapies, which has been shown to effectively slow the progression of the "wet" form of age-related macular degeneration (AMD), and even to stabilize visual acuity over many years. Although, due to considerable advance of AMD treatment, it is currently not recommended in monotherapy of AMD, however, its combination with steroids and anti-angiogenic biologic drugs may reveal high therapeutic potential in the treatment of neovascular AMD. The future of VTP as a method of AMD treatment is development of new selective and targeted photosensitizer and combination of this method with other therapeutic strategies targeting cellular structures or pathways involved in AMD progression.

Authors+Show Affiliations

Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Bytom, Poland; Silesian Medical University, Katowice, Poland; The Department of Medicine and Division of Medicine and Dentistry, Zabrze, Poland. Electronic address: akawczyk@gmail.com.Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Bytom, Poland; Silesian Medical University, Katowice, Poland; The Department of Medicine and Division of Medicine and Dentistry, Zabrze, Poland; College of Health, Beauty Care and Education, Poznań, Poland.Silesian Medical University, Katowice, Poland; The Department of Medicine and Division of Medicine and Dentistry, Zabrze, Poland.Newnham College, University of Cambridge, Cambridge, United Kingdom.Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Bytom, Poland; Silesian Medical University, Katowice, Poland; The Department of Medicine and Division of Medicine and Dentistry, Zabrze, Poland.Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Bytom, Poland; Silesian Medical University, Katowice, Poland; The Department of Medicine and Division of Medicine and Dentistry, Zabrze, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25843911

Citation

Kawczyk-Krupka, A, et al. "Vascular-targeted Photodynamic Therapy in the Treatment of Neovascular Age-related Macular Degeneration: Clinical Perspectives." Photodiagnosis and Photodynamic Therapy, vol. 12, no. 2, 2015, pp. 161-75.
Kawczyk-Krupka A, Bugaj AM, Potempa M, et al. Vascular-targeted photodynamic therapy in the treatment of neovascular age-related macular degeneration: Clinical perspectives. Photodiagnosis Photodyn Ther. 2015;12(2):161-75.
Kawczyk-Krupka, A., Bugaj, A. M., Potempa, M., Wasilewska, K., Latos, W., & Sieroń, A. (2015). Vascular-targeted photodynamic therapy in the treatment of neovascular age-related macular degeneration: Clinical perspectives. Photodiagnosis and Photodynamic Therapy, 12(2), 161-75. https://doi.org/10.1016/j.pdpdt.2015.03.007
Kawczyk-Krupka A, et al. Vascular-targeted Photodynamic Therapy in the Treatment of Neovascular Age-related Macular Degeneration: Clinical Perspectives. Photodiagnosis Photodyn Ther. 2015;12(2):161-75. PubMed PMID: 25843911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular-targeted photodynamic therapy in the treatment of neovascular age-related macular degeneration: Clinical perspectives. AU - Kawczyk-Krupka,A, AU - Bugaj,A M, AU - Potempa,M, AU - Wasilewska,K, AU - Latos,W, AU - Sieroń,A, Y1 - 2015/04/03/ PY - 2014/11/30/received PY - 2015/03/09/revised PY - 2015/03/10/accepted PY - 2015/4/7/entrez PY - 2015/4/7/pubmed PY - 2016/3/5/medline KW - Age-related macular degeneration KW - Clinical trials KW - Vascular-targeted photodynamic therapy KW - Verteporfin SP - 161 EP - 75 JF - Photodiagnosis and photodynamic therapy JO - Photodiagnosis Photodyn Ther VL - 12 IS - 2 N2 - Vascular targeted photodynamic therapy (VTP), with use of verteporfin as a photosensitizer is one of the few therapies, which has been shown to effectively slow the progression of the "wet" form of age-related macular degeneration (AMD), and even to stabilize visual acuity over many years. Although, due to considerable advance of AMD treatment, it is currently not recommended in monotherapy of AMD, however, its combination with steroids and anti-angiogenic biologic drugs may reveal high therapeutic potential in the treatment of neovascular AMD. The future of VTP as a method of AMD treatment is development of new selective and targeted photosensitizer and combination of this method with other therapeutic strategies targeting cellular structures or pathways involved in AMD progression. SN - 1873-1597 UR - https://www.unboundmedicine.com/medline/citation/25843911/Vascular_targeted_photodynamic_therapy_in_the_treatment_of_neovascular_age_related_macular_degeneration:_Clinical_perspectives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1572-1000(15)00034-4 DB - PRIME DP - Unbound Medicine ER -