Tags

Type your tag names separated by a space and hit enter

Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases.
Sleep. 2015 Sep 01; 38(9):1451-9.S

Abstract

STUDY OBJECTIVES

Sleep disordered breathing (SDB) is a highly prevalent condition in high-income countries, with major consequences for cardiopulmonary health, public safety, healthcare utilization, and mortality. However, its prevalence and effect in low- and middle-income countries are less well known. We sought to determine the prevalence, risk factors, and comorbidities of SDB symptoms in four resource-limited settings.

DESIGN

Cross-sectional analysis of the CRONICAS Cohort, a population-based age- and sex-stratified sample.

SETTING

Four resource-limited settings in Peru varying in altitude, urbanization, and air pollution.

PARTICIPANTS

There were 2,682 adults aged 35 to 92 y.

MEASUREMENTS AND RESULTS

Self-reported SDB symptoms (habitual snoring, observed apneas, Epworth Sleepiness Scale), sociodemographics, medical history, anthropometrics, spirometry, blood biomarkers were reported. We found a high prevalence of habitual snoring (30.2%, 95% confidence interval [CI] 28.5-32.0%), observed apneas (20.9%, 95% CI 19.4-22.5%) and excessive daytime sleepiness (18.6%, 95% CI 17.1-20.1%). SDB symptoms varied across sites; prevalence and adjusted odds for habitual snoring were greatest at sea level, whereas those for observed apneas were greatest at high altitude. In multivariable analysis, habitual snoring was associated with older age, male sex, body mass index (BMI), and higher socioeconomic status; observed apneas were associated with BMI; and excessive daytime sleepiness was associated with older age, female sex, and medium socioeconomic status. Adjusted odds of cardiovascular disease, depression, and hypertension and total chronic disease burden increased progressively with the number of SDB symptoms. A threefold increase in the odds of having an additional chronic comorbid disease (adjusted odds ratio 3.57, 95% CI 2.18-5.84) was observed in those with all three versus no SDB symptoms.

CONCLUSIONS

Sleep disordered breathing symptoms were highly prevalent, varied widely across four resource-limited settings in Peru, and exhibited strong independent associations with chronic diseases.

Authors+Show Affiliations

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD. Pritzker School of Medicine, University of Chicago, Chicago, IL.Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD.Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD.Pritzker School of Medicine, University of Chicago, Chicago, IL.Program in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru. Departamento de Medicina, Escuela de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD. Program in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25845694

Citation

Schwartz, Noah G., et al. "Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association With Chronic Diseases." Sleep, vol. 38, no. 9, 2015, pp. 1451-9.
Schwartz NG, Rattner A, Schwartz AR, et al. Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases. Sleep. 2015;38(9):1451-9.
Schwartz, N. G., Rattner, A., Schwartz, A. R., Mokhlesi, B., Gilman, R. H., Bernabe-Ortiz, A., Miranda, J. J., & Checkley, W. (2015). Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases. Sleep, 38(9), 1451-9. https://doi.org/10.5665/sleep.4988
Schwartz NG, et al. Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association With Chronic Diseases. Sleep. 2015 Sep 1;38(9):1451-9. PubMed PMID: 25845694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases. AU - Schwartz,Noah G, AU - Rattner,Adi, AU - Schwartz,Alan R, AU - Mokhlesi,Babak, AU - Gilman,Robert H, AU - Bernabe-Ortiz,Antonio, AU - Miranda,J Jaime, AU - Checkley,William, AU - ,, Y1 - 2015/09/01/ PY - 2014/10/03/received PY - 2015/03/07/accepted PY - 2015/4/8/entrez PY - 2015/4/8/pubmed PY - 2016/1/15/medline KW - chronic diseases KW - population-based study KW - sleep disordered breathing SP - 1451 EP - 9 JF - Sleep JO - Sleep VL - 38 IS - 9 N2 - STUDY OBJECTIVES: Sleep disordered breathing (SDB) is a highly prevalent condition in high-income countries, with major consequences for cardiopulmonary health, public safety, healthcare utilization, and mortality. However, its prevalence and effect in low- and middle-income countries are less well known. We sought to determine the prevalence, risk factors, and comorbidities of SDB symptoms in four resource-limited settings. DESIGN: Cross-sectional analysis of the CRONICAS Cohort, a population-based age- and sex-stratified sample. SETTING: Four resource-limited settings in Peru varying in altitude, urbanization, and air pollution. PARTICIPANTS: There were 2,682 adults aged 35 to 92 y. MEASUREMENTS AND RESULTS: Self-reported SDB symptoms (habitual snoring, observed apneas, Epworth Sleepiness Scale), sociodemographics, medical history, anthropometrics, spirometry, blood biomarkers were reported. We found a high prevalence of habitual snoring (30.2%, 95% confidence interval [CI] 28.5-32.0%), observed apneas (20.9%, 95% CI 19.4-22.5%) and excessive daytime sleepiness (18.6%, 95% CI 17.1-20.1%). SDB symptoms varied across sites; prevalence and adjusted odds for habitual snoring were greatest at sea level, whereas those for observed apneas were greatest at high altitude. In multivariable analysis, habitual snoring was associated with older age, male sex, body mass index (BMI), and higher socioeconomic status; observed apneas were associated with BMI; and excessive daytime sleepiness was associated with older age, female sex, and medium socioeconomic status. Adjusted odds of cardiovascular disease, depression, and hypertension and total chronic disease burden increased progressively with the number of SDB symptoms. A threefold increase in the odds of having an additional chronic comorbid disease (adjusted odds ratio 3.57, 95% CI 2.18-5.84) was observed in those with all three versus no SDB symptoms. CONCLUSIONS: Sleep disordered breathing symptoms were highly prevalent, varied widely across four resource-limited settings in Peru, and exhibited strong independent associations with chronic diseases. SN - 1550-9109 UR - https://www.unboundmedicine.com/medline/citation/25845694/Sleep_Disordered_Breathing_in_Four_Resource_Limited_Settings_in_Peru:_Prevalence_Risk_Factors_and_Association_with_Chronic_Diseases_ L2 - https://academic.oup.com/sleep/article-lookup/doi/10.5665/sleep.4988 DB - PRIME DP - Unbound Medicine ER -