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[A case of bisalbuminemia in a patient with digestive adenocarcinoma].
Ann Biol Clin (Paris). 2015 Mar-Apr; 73(2):190-4.AB

Abstract

Bisalbuminemia whether hereditary or acquired, is a rare electrophoretic abnormality of albumin, characterized by a duplication of the albumin fraction on the electrophoretic trace of the serum proteins. This duplication reflects the presence in the same individual normal plasma albumin and a modified albumin.

OBSERVATION

This is a patient of 62 years hospitalized at the Internal Medicine Department of HMIMV for liver metastases of gastrointestinal adenocarcinoma and including serum protein electrophoresis (EP) performed on capillary (Capillarys society Sebia) reveals bisalbuminemia. The family investigation has ruled that inheritance of acquired bisalbuminemia to retain appearance.

COMMENT

Bisalbuminemia acquired outside treatment with high doses of beta-lactam antibiotics, chronic pancreatitis with pseudocyst rupture or fixing a monoclonal immunoglobulin on albumin in the myeloma subjects is an exceptional event. The pathophysiologic mechanism in the reported cases remains unexplained as is also the case of acquired bisalbuminemias associated with other pathological contexts (Alzheimer's disease nephrotic syndrome).

CONCLUSION

To the best of our knowledge, the bisalbuminemia in the gastrointestinal adenocarcinoma liver metastases has not been reported to date, hence the importance of the reported cases.

Authors+Show Affiliations

Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

25847742

Citation

Hajoui, Fatima Zahra, et al. "[A Case of Bisalbuminemia in a Patient With Digestive Adenocarcinoma]." Annales De Biologie Clinique, vol. 73, no. 2, 2015, pp. 190-4.
Hajoui FZ, Biaz A, Zouiten L, et al. [A case of bisalbuminemia in a patient with digestive adenocarcinoma]. Ann Biol Clin (Paris). 2015;73(2):190-4.
Hajoui, F. Z., Biaz, A., Zouiten, L., Mechtani, S., Dami, A., Bouhsain, S., & Ouzzif, Z. (2015). [A case of bisalbuminemia in a patient with digestive adenocarcinoma]. Annales De Biologie Clinique, 73(2), 190-4. https://doi.org/10.1684/abc.2015.1028
Hajoui FZ, et al. [A Case of Bisalbuminemia in a Patient With Digestive Adenocarcinoma]. Ann Biol Clin (Paris). 2015 Mar-Apr;73(2):190-4. PubMed PMID: 25847742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of bisalbuminemia in a patient with digestive adenocarcinoma]. AU - Hajoui,Fatima Zahra, AU - Biaz,Asmaa, AU - Zouiten,Lamyaa, AU - Mechtani,Samira, AU - Dami,Abdellah, AU - Bouhsain,Sanaa, AU - Ouzzif,Zohra, PY - 2015/4/8/entrez PY - 2015/4/8/pubmed PY - 2016/4/14/medline KW - adenocarcinoma KW - bisalbuminemia KW - liver metastases SP - 190 EP - 4 JF - Annales de biologie clinique JO - Ann. Biol. Clin. (Paris) VL - 73 IS - 2 N2 - UNLABELLED: Bisalbuminemia whether hereditary or acquired, is a rare electrophoretic abnormality of albumin, characterized by a duplication of the albumin fraction on the electrophoretic trace of the serum proteins. This duplication reflects the presence in the same individual normal plasma albumin and a modified albumin. OBSERVATION: This is a patient of 62 years hospitalized at the Internal Medicine Department of HMIMV for liver metastases of gastrointestinal adenocarcinoma and including serum protein electrophoresis (EP) performed on capillary (Capillarys society Sebia) reveals bisalbuminemia. The family investigation has ruled that inheritance of acquired bisalbuminemia to retain appearance. COMMENT: Bisalbuminemia acquired outside treatment with high doses of beta-lactam antibiotics, chronic pancreatitis with pseudocyst rupture or fixing a monoclonal immunoglobulin on albumin in the myeloma subjects is an exceptional event. The pathophysiologic mechanism in the reported cases remains unexplained as is also the case of acquired bisalbuminemias associated with other pathological contexts (Alzheimer's disease nephrotic syndrome). CONCLUSION: To the best of our knowledge, the bisalbuminemia in the gastrointestinal adenocarcinoma liver metastases has not been reported to date, hence the importance of the reported cases. SN - 1950-6112 UR - https://www.unboundmedicine.com/medline/citation/25847742/[A_case_of_bisalbuminemia_in_a_patient_with_digestive_adenocarcinoma]_ L2 - http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/abc.2015.1028 DB - PRIME DP - Unbound Medicine ER -