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Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug.
Drug Des Devel Ther. 2015; 9:1843-57.DD

Abstract

The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate. Pentoxifylline was used as a highly water-soluble, short half-life model drug with a high density. The floating capacity, swelling, and drug release behaviors of drug-loaded matrix tablets were evaluated in 0.1 N HCl (pH 1.2) at 37°C±0.5°C. Release data were analyzed by fitting the power law model of Korsmeyer-Peppas. The effect of different formulation variables was investigated, such as wet granulation, sodium bicarbonate gas-forming agent level, and tablet hardness properties. Statistical analysis was applied by paired sample t-test and one-way analysis of variance depending on the type of data to determine significant effect of different parameters. All prepared tablets through wet granulation showed acceptable physicochemical properties and their drug release profiles followed non-Fickian diffusion. They could float on the surface of dissolution medium and sustain drug release over 24 hours. Tablets prepared with 20% w/w sodium bicarbonate at 50-54 N hardness were promising with respect to their floating lag time, floating duration, swelling ability, and sustained drug release profile.

Authors+Show Affiliations

Department of Pharmacy, Health and Well-being, University of Sunderland, Sunderland, United Kingdom ; Faculty of Pharmacy, Applied Science University, Amman, Jordan.Department of Pharmacy, Health and Well-being, University of Sunderland, Sunderland, United Kingdom.Department of Pharmacy, Health and Well-being, University of Sunderland, Sunderland, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25848220

Citation

Rahim, Safwan Abdel, et al. "Design and Evaluation of Effervescent Floating Tablets Based On Hydroxyethyl Cellulose and Sodium Alginate Using Pentoxifylline as a Model Drug." Drug Design, Development and Therapy, vol. 9, 2015, pp. 1843-57.
Rahim SA, Carter PA, Elkordy AA. Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug. Drug Des Devel Ther. 2015;9:1843-57.
Rahim, S. A., Carter, P. A., & Elkordy, A. A. (2015). Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug. Drug Design, Development and Therapy, 9, 1843-57. https://doi.org/10.2147/DDDT.S78717
Rahim SA, Carter PA, Elkordy AA. Design and Evaluation of Effervescent Floating Tablets Based On Hydroxyethyl Cellulose and Sodium Alginate Using Pentoxifylline as a Model Drug. Drug Des Devel Ther. 2015;9:1843-57. PubMed PMID: 25848220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug. AU - Rahim,Safwan Abdel, AU - Carter,Paul A, AU - Elkordy,Amal Ali, Y1 - 2015/03/31/ PY - 2015/4/8/entrez PY - 2015/4/8/pubmed PY - 2016/9/14/medline KW - dissolution KW - effervescent KW - floating tablets KW - pentoxifylline KW - sodium alginate KW - swelling SP - 1843 EP - 57 JF - Drug design, development and therapy JO - Drug Des Devel Ther VL - 9 N2 - The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate. Pentoxifylline was used as a highly water-soluble, short half-life model drug with a high density. The floating capacity, swelling, and drug release behaviors of drug-loaded matrix tablets were evaluated in 0.1 N HCl (pH 1.2) at 37°C±0.5°C. Release data were analyzed by fitting the power law model of Korsmeyer-Peppas. The effect of different formulation variables was investigated, such as wet granulation, sodium bicarbonate gas-forming agent level, and tablet hardness properties. Statistical analysis was applied by paired sample t-test and one-way analysis of variance depending on the type of data to determine significant effect of different parameters. All prepared tablets through wet granulation showed acceptable physicochemical properties and their drug release profiles followed non-Fickian diffusion. They could float on the surface of dissolution medium and sustain drug release over 24 hours. Tablets prepared with 20% w/w sodium bicarbonate at 50-54 N hardness were promising with respect to their floating lag time, floating duration, swelling ability, and sustained drug release profile. SN - 1177-8881 UR - https://www.unboundmedicine.com/medline/citation/25848220/Design_and_evaluation_of_effervescent_floating_tablets_based_on_hydroxyethyl_cellulose_and_sodium_alginate_using_pentoxifylline_as_a_model_drug_ L2 - https://dx.doi.org/10.2147/DDDT.S78717 DB - PRIME DP - Unbound Medicine ER -