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Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter.
Nat Rev Drug Discov. 2015 May; 14(5):329-45.NR

Abstract

Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.

Authors+Show Affiliations

1] Department of Physiology &Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada. [2] Department of Pharmacology &Toxicology, University of Toronto, Toronto, Ontario M5S 2J7, Canada.Department of Biology, Lakehead University, Thunder Bay, Ontario P7B5E1, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25849904

Citation

Wallace, John L., and Rui Wang. "Hydrogen Sulfide-based Therapeutics: Exploiting a Unique but Ubiquitous Gasotransmitter." Nature Reviews. Drug Discovery, vol. 14, no. 5, 2015, pp. 329-45.
Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14(5):329-45.
Wallace, J. L., & Wang, R. (2015). Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nature Reviews. Drug Discovery, 14(5), 329-45. https://doi.org/10.1038/nrd4433
Wallace JL, Wang R. Hydrogen Sulfide-based Therapeutics: Exploiting a Unique but Ubiquitous Gasotransmitter. Nat Rev Drug Discov. 2015;14(5):329-45. PubMed PMID: 25849904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. AU - Wallace,John L, AU - Wang,Rui, Y1 - 2015/04/07/ PY - 2015/4/8/entrez PY - 2015/4/8/pubmed PY - 2015/7/7/medline SP - 329 EP - 45 JF - Nature reviews. Drug discovery JO - Nat Rev Drug Discov VL - 14 IS - 5 N2 - Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials. SN - 1474-1784 UR - https://www.unboundmedicine.com/medline/citation/25849904/Hydrogen_sulfide_based_therapeutics:_exploiting_a_unique_but_ubiquitous_gasotransmitter_ L2 - https://doi.org/10.1038/nrd4433 DB - PRIME DP - Unbound Medicine ER -