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Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo.
Nat Neurosci 2015; 18(5):628-30NN

Abstract

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

Authors+Show Affiliations

Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media

Language

eng

PubMed ID

25849985

Citation

Mensch, Sigrid, et al. "Synaptic Vesicle Release Regulates Myelin Sheath Number of Individual Oligodendrocytes in Vivo." Nature Neuroscience, vol. 18, no. 5, 2015, pp. 628-30.
Mensch S, Baraban M, Almeida R, et al. Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat Neurosci. 2015;18(5):628-30.
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015). Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nature Neuroscience, 18(5), pp. 628-30. doi:10.1038/nn.3991.
Mensch S, et al. Synaptic Vesicle Release Regulates Myelin Sheath Number of Individual Oligodendrocytes in Vivo. Nat Neurosci. 2015;18(5):628-30. PubMed PMID: 25849985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. AU - Mensch,Sigrid, AU - Baraban,Marion, AU - Almeida,Rafael, AU - Czopka,Tim, AU - Ausborn,Jessica, AU - El Manira,Abdeljabbar, AU - Lyons,David A, Y1 - 2015/04/06/ PY - 2014/08/06/received PY - 2015/02/23/accepted PY - 2015/4/8/entrez PY - 2015/4/8/pubmed PY - 2015/7/15/medline SP - 628 EP - 30 JF - Nature neuroscience JO - Nat. Neurosci. VL - 18 IS - 5 N2 - The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes. SN - 1546-1726 UR - https://www.unboundmedicine.com/medline/citation/25849985/Synaptic_vesicle_release_regulates_myelin_sheath_number_of_individual_oligodendrocytes_in_vivo_ L2 - http://dx.doi.org/10.1038/nn.3991 DB - PRIME DP - Unbound Medicine ER -