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[Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury].
Zhongguo Zhong Yao Za Zhi. 2014 Nov; 39(22):4389-93.ZZ

Abstract

This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method. The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship. Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, galloylpaeoniflorin and paeonol were the main effective components.

Authors

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Pub Type(s)

Journal Article

Language

chi

PubMed ID

25850273

Citation

Tang, Ming-jie, et al. "[Spectrum-effect Relationship of Moutan Cortex Against Lipopolysaccharide-induced Acute Lung Injury]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 39, no. 22, 2014, pp. 4389-93.
Tang MJ, Ye YS, Zhang Q, et al. [Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury]. Zhongguo Zhong Yao Za Zhi. 2014;39(22):4389-93.
Tang, M. J., Ye, Y. S., Zhang, Q., Li, J., Lei, H. M., Cai, C. K., & Li, Q. (2014). [Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 39(22), 4389-93.
Tang MJ, et al. [Spectrum-effect Relationship of Moutan Cortex Against Lipopolysaccharide-induced Acute Lung Injury]. Zhongguo Zhong Yao Za Zhi. 2014;39(22):4389-93. PubMed PMID: 25850273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury]. AU - Tang,Ming-jie, AU - Ye,Yong-shan, AU - Zhang,Qi, AU - Li,Jian, AU - Lei,Hai-min, AU - Cai,Cheng-ke, AU - Li,Qiang, PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2015/4/29/medline SP - 4389 EP - 93 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 39 IS - 22 N2 - This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method. The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship. Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, galloylpaeoniflorin and paeonol were the main effective components. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/25850273/[Spectrum_effect_relationship_of_Moutan_cortex_against_lipopolysaccharide_induced_acute_lung_injury]_ DB - PRIME DP - Unbound Medicine ER -