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Norepinephrine and learning-induced plasticity in infant rat olfactory system.
J Neurosci. 1989 Nov; 9(11):3998-4006.JN

Abstract

Postnatal olfactory learning produces both a conditioned behavioral response and a modified olfactory bulb neural response to the learned odor. The present report describes the role of norepinephrine (NE) on both of these learned responses in neonatal rat pups. Pups received olfactory classical conditioning training from postnatal days (PN) 1-18. Training consisted of 18 trials with an intertrial interval of 24 hr. For the experimental group, a trial consisted of a pairing of unconditioned stimulus (UCS, stroking/tactile stimulation) and the conditioned stimulus (CS, odor). Control groups received either only the CS (Odor only) or only the UCS (Stroke only). Within each training condition, pups were injected with either the NE beta-receptor agonist isoproterenol (1, 20, or 4 mg/kg), the NE beta-receptor antagonist propranolol (10, 20, 40 mg/kg), or saline 30 min prior to training. On day 20, pups received one of the following tests: (1) behavioral conditioned responding, (2) injection with 14C-2-deoxyglucose (2-DG) and exposed to the CS odor, or (3) tested for olfactory bulb mitral/tufted cell single-unit responses to the CS odor. The results indicated that training with either: (1) Odor-Stroke-Saline, (2) Odor-Stroke-Isoproterenol-Propranolol, or (3) Odor only-Isoproterenol (2 mg/kg) was sufficient to produce a learned behavioral odor preference, enhanced uptake of 14C-2-DG in the odor-specific foci within the bulb, and a modified output signal from the bulb as measured by single-cell recordings of mitral/tufted cells. Moreover, propranolol injected prior to Odor-Stroke training blocked the acquisition of both the learned behavior and olfactory bulb responses. Thus, NE is sufficient and may be necessary for the acquisition of both learned olfactory behavior and olfactory bulb responses.

Authors+Show Affiliations

Department of Psychobiology, University of California, Irvine 92717.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2585063

Citation

Sullivan, R M., et al. "Norepinephrine and Learning-induced Plasticity in Infant Rat Olfactory System." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 9, no. 11, 1989, pp. 3998-4006.
Sullivan RM, Wilson DA, Leon M. Norepinephrine and learning-induced plasticity in infant rat olfactory system. J Neurosci. 1989;9(11):3998-4006.
Sullivan, R. M., Wilson, D. A., & Leon, M. (1989). Norepinephrine and learning-induced plasticity in infant rat olfactory system. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 9(11), 3998-4006.
Sullivan RM, Wilson DA, Leon M. Norepinephrine and Learning-induced Plasticity in Infant Rat Olfactory System. J Neurosci. 1989;9(11):3998-4006. PubMed PMID: 2585063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Norepinephrine and learning-induced plasticity in infant rat olfactory system. AU - Sullivan,R M, AU - Wilson,D A, AU - Leon,M, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 3998 EP - 4006 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 9 IS - 11 N2 - Postnatal olfactory learning produces both a conditioned behavioral response and a modified olfactory bulb neural response to the learned odor. The present report describes the role of norepinephrine (NE) on both of these learned responses in neonatal rat pups. Pups received olfactory classical conditioning training from postnatal days (PN) 1-18. Training consisted of 18 trials with an intertrial interval of 24 hr. For the experimental group, a trial consisted of a pairing of unconditioned stimulus (UCS, stroking/tactile stimulation) and the conditioned stimulus (CS, odor). Control groups received either only the CS (Odor only) or only the UCS (Stroke only). Within each training condition, pups were injected with either the NE beta-receptor agonist isoproterenol (1, 20, or 4 mg/kg), the NE beta-receptor antagonist propranolol (10, 20, 40 mg/kg), or saline 30 min prior to training. On day 20, pups received one of the following tests: (1) behavioral conditioned responding, (2) injection with 14C-2-deoxyglucose (2-DG) and exposed to the CS odor, or (3) tested for olfactory bulb mitral/tufted cell single-unit responses to the CS odor. The results indicated that training with either: (1) Odor-Stroke-Saline, (2) Odor-Stroke-Isoproterenol-Propranolol, or (3) Odor only-Isoproterenol (2 mg/kg) was sufficient to produce a learned behavioral odor preference, enhanced uptake of 14C-2-DG in the odor-specific foci within the bulb, and a modified output signal from the bulb as measured by single-cell recordings of mitral/tufted cells. Moreover, propranolol injected prior to Odor-Stroke training blocked the acquisition of both the learned behavior and olfactory bulb responses. Thus, NE is sufficient and may be necessary for the acquisition of both learned olfactory behavior and olfactory bulb responses. SN - 0270-6474 UR - https://www.unboundmedicine.com/medline/citation/2585063/Norepinephrine_and_learning_induced_plasticity_in_infant_rat_olfactory_system_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=2585063 DB - PRIME DP - Unbound Medicine ER -