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Diet and cognitive decline at middle age: the role of antioxidants.
Br J Nutr 2015; 113(9):1410-7BJ

Abstract

To assess the relationship between dietary intake of antioxidants (vitamin C, vitamin E, β-carotene, lutein, flavonoids and lignans) and cognitive decline at middle age, analyses were performed on data from the population based Doetinchem Cohort Study. Habitual diet and cognitive function were assessed twice with a 5-year interval in 2613 persons aged 43-70 year at baseline (1995-2002). Diet was assessed with a validated 178-item semi-quantitative FFQ. Cognitive function was assessed with a neuropsychological test battery, consisting of the 15 Words Learning Test, the Stroop Test, the Word Fluency test, and the Letter Digit Substitution Test. Scores on global cognitive function, memory, processing speed, and cognitive flexibility were calculated. In regression analyses, quintiles of antioxidant intake were associated with change in cognitive domain scores. Results showed that higher lignan intake was linearly associated with less decline in global cognitive function (P= 0.01), memory (P< 0.01) and processing speed (P= 0.04), with about two times less declines in the highest v. the lowest quintile. In the lowest quintile of vitamin E intake, decline in memory was twice as fast as in all higher quintiles (P< 0.01). Global cognitive decline in the highest lutein intake group was greater than in the lowest intake group (P< 0.05). Higher flavonoid intake was associated with greater decline in cognitive flexibility (P for trend = 0.04). Intakes of other antioxidants were not associated with cognitive decline. We conclude that within the range of a habitual dietary intake, higher intake of lignans is associated with less cognitive decline at middle age.

Authors+Show Affiliations

Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM),PO Box 1,3720BABilthoven,The Netherlands.Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM),PO Box 1,3720BABilthoven,The Netherlands.Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM),PO Box 1,3720BABilthoven,The Netherlands.Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM),PO Box 1,3720BABilthoven,The Netherlands.Department of Psychiatry and Neuropsychology,Maastricht University,Postbus 616,6200MD,Maastricht,The Netherlands.Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM),PO Box 1,3720BABilthoven,The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25851267

Citation

Nooyens, Astrid C J., et al. "Diet and Cognitive Decline at Middle Age: the Role of Antioxidants." The British Journal of Nutrition, vol. 113, no. 9, 2015, pp. 1410-7.
Nooyens AC, Milder IE, van Gelder BM, et al. Diet and cognitive decline at middle age: the role of antioxidants. Br J Nutr. 2015;113(9):1410-7.
Nooyens, A. C., Milder, I. E., van Gelder, B. M., Bueno-de-Mesquita, H. B., van Boxtel, M. P., & Verschuren, W. M. (2015). Diet and cognitive decline at middle age: the role of antioxidants. The British Journal of Nutrition, 113(9), pp. 1410-7. doi:10.1017/S0007114515000720.
Nooyens AC, et al. Diet and Cognitive Decline at Middle Age: the Role of Antioxidants. Br J Nutr. 2015 May 14;113(9):1410-7. PubMed PMID: 25851267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and cognitive decline at middle age: the role of antioxidants. AU - Nooyens,Astrid C J, AU - Milder,Ivon E J, AU - van Gelder,Boukje M, AU - Bueno-de-Mesquita,H Bas, AU - van Boxtel,Martin P J, AU - Verschuren,W M Monique, Y1 - 2015/04/08/ PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2015/8/4/medline KW - Antioxidants KW - Cognitive decline KW - Cohort studies KW - Middle-aged populations SP - 1410 EP - 7 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 9 N2 - To assess the relationship between dietary intake of antioxidants (vitamin C, vitamin E, β-carotene, lutein, flavonoids and lignans) and cognitive decline at middle age, analyses were performed on data from the population based Doetinchem Cohort Study. Habitual diet and cognitive function were assessed twice with a 5-year interval in 2613 persons aged 43-70 year at baseline (1995-2002). Diet was assessed with a validated 178-item semi-quantitative FFQ. Cognitive function was assessed with a neuropsychological test battery, consisting of the 15 Words Learning Test, the Stroop Test, the Word Fluency test, and the Letter Digit Substitution Test. Scores on global cognitive function, memory, processing speed, and cognitive flexibility were calculated. In regression analyses, quintiles of antioxidant intake were associated with change in cognitive domain scores. Results showed that higher lignan intake was linearly associated with less decline in global cognitive function (P= 0.01), memory (P< 0.01) and processing speed (P= 0.04), with about two times less declines in the highest v. the lowest quintile. In the lowest quintile of vitamin E intake, decline in memory was twice as fast as in all higher quintiles (P< 0.01). Global cognitive decline in the highest lutein intake group was greater than in the lowest intake group (P< 0.05). Higher flavonoid intake was associated with greater decline in cognitive flexibility (P for trend = 0.04). Intakes of other antioxidants were not associated with cognitive decline. We conclude that within the range of a habitual dietary intake, higher intake of lignans is associated with less cognitive decline at middle age. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25851267/Diet_and_cognitive_decline_at_middle_age:_the_role_of_antioxidants_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515000720/type/journal_article DB - PRIME DP - Unbound Medicine ER -