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Associations between renal hyperfiltration and serum alkaline phosphatase.
PLoS One 2015; 10(4):e0122921Plos

Abstract

Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): >120, 90-119, 60-89, and <60 mL/min/1.73 m2. The participants with eGFR >120 mL/min/1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2. The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95% CI, 1.204-2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, Korea.Division of Nephrology, Department of Internal Medicine, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, Korea.Division of Nephrology, Department of Internal Medicine, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25853240

Citation

Oh, Se Won, et al. "Associations Between Renal Hyperfiltration and Serum Alkaline Phosphatase." PloS One, vol. 10, no. 4, 2015, pp. e0122921.
Oh SW, Han KH, Han SY. Associations between renal hyperfiltration and serum alkaline phosphatase. PLoS ONE. 2015;10(4):e0122921.
Oh, S. W., Han, K. H., & Han, S. Y. (2015). Associations between renal hyperfiltration and serum alkaline phosphatase. PloS One, 10(4), pp. e0122921. doi:10.1371/journal.pone.0122921.
Oh SW, Han KH, Han SY. Associations Between Renal Hyperfiltration and Serum Alkaline Phosphatase. PLoS ONE. 2015;10(4):e0122921. PubMed PMID: 25853240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between renal hyperfiltration and serum alkaline phosphatase. AU - Oh,Se Won, AU - Han,Kum Hyun, AU - Han,Sang Youb, Y1 - 2015/04/08/ PY - 2014/09/30/received PY - 2015/01/20/accepted PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2016/3/26/medline SP - e0122921 EP - e0122921 JF - PloS one JO - PLoS ONE VL - 10 IS - 4 N2 - Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): >120, 90-119, 60-89, and <60 mL/min/1.73 m2. The participants with eGFR >120 mL/min/1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2. The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95% CI, 1.204-2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25853240/Associations_between_renal_hyperfiltration_and_serum_alkaline_phosphatase_ L2 - http://dx.plos.org/10.1371/journal.pone.0122921 DB - PRIME DP - Unbound Medicine ER -