Tags

Type your tag names separated by a space and hit enter

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men.
PLoS One 2015; 10(4):e0124028Plos

Abstract

BACKGROUND

Hyperproinsulinemia is an indicator of β-cell dysfunction, and fasting proinsulin levels are elevated in patients with hyperglycemia. It is not known whether proinsulin levels after a glucose load are better predictors of hyperglycemia and type 2 diabetes than fasting proinsulin.

METHODS

Participants were 9,396 Finnish men (mean±SD, age 57.3±7.1 years, BMI 27.0±4.0 kg/m2) of the population-based METabolic Syndrome In Men Study who were non-diabetic at the recruitment, and who participated in a 6-year follow-up study. Proinsulin and insulin levels were measured in the fasting state and 30 and 120 min after an oral glucose load. Area under the curve (AUC) and proinsulin to insulin ratios were calculated.

RESULTS

Fasting proinsulin, proinsulin at 30 min and proinsulin AUC during the first 30 min of an oral glucose tolerance test significantly predicted both the worsening of hyperglycemia and type 2 diabetes after adjustment for confounding factors. Further adjustment for insulin sensitivity (Matsuda index) or insulin secretion (Disposition index) weakened these associations. Insulin sensitivity had a major impact on these associations.

CONCLUSION

Our results suggest that proinsulin in the fasting state and after an oral glucose load similarly predict the worsening of hyperglycemia and conversion to type 2 diabetes.

Authors+Show Affiliations

Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25853252

Citation

Vangipurapu, Jagadish, et al. "Both Fasting and Glucose-stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: a Population-based Study of 9,396 Finnish Men." PloS One, vol. 10, no. 4, 2015, pp. e0124028.
Vangipurapu J, Stančáková A, Kuulasmaa T, et al. Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men. PLoS ONE. 2015;10(4):e0124028.
Vangipurapu, J., Stančáková, A., Kuulasmaa, T., Kuusisto, J., & Laakso, M. (2015). Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men. PloS One, 10(4), pp. e0124028. doi:10.1371/journal.pone.0124028.
Vangipurapu J, et al. Both Fasting and Glucose-stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: a Population-based Study of 9,396 Finnish Men. PLoS ONE. 2015;10(4):e0124028. PubMed PMID: 25853252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men. AU - Vangipurapu,Jagadish, AU - Stančáková,Alena, AU - Kuulasmaa,Teemu, AU - Kuusisto,Johanna, AU - Laakso,Markku, Y1 - 2015/04/08/ PY - 2014/10/23/received PY - 2015/03/09/accepted PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2016/3/24/medline SP - e0124028 EP - e0124028 JF - PloS one JO - PLoS ONE VL - 10 IS - 4 N2 - BACKGROUND: Hyperproinsulinemia is an indicator of β-cell dysfunction, and fasting proinsulin levels are elevated in patients with hyperglycemia. It is not known whether proinsulin levels after a glucose load are better predictors of hyperglycemia and type 2 diabetes than fasting proinsulin. METHODS: Participants were 9,396 Finnish men (mean±SD, age 57.3±7.1 years, BMI 27.0±4.0 kg/m2) of the population-based METabolic Syndrome In Men Study who were non-diabetic at the recruitment, and who participated in a 6-year follow-up study. Proinsulin and insulin levels were measured in the fasting state and 30 and 120 min after an oral glucose load. Area under the curve (AUC) and proinsulin to insulin ratios were calculated. RESULTS: Fasting proinsulin, proinsulin at 30 min and proinsulin AUC during the first 30 min of an oral glucose tolerance test significantly predicted both the worsening of hyperglycemia and type 2 diabetes after adjustment for confounding factors. Further adjustment for insulin sensitivity (Matsuda index) or insulin secretion (Disposition index) weakened these associations. Insulin sensitivity had a major impact on these associations. CONCLUSION: Our results suggest that proinsulin in the fasting state and after an oral glucose load similarly predict the worsening of hyperglycemia and conversion to type 2 diabetes. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25853252/Both_fasting_and_glucose_stimulated_proinsulin_levels_predict_hyperglycemia_and_incident_type_2_diabetes:_a_population_based_study_of_9396_Finnish_men_ L2 - http://dx.plos.org/10.1371/journal.pone.0124028 DB - PRIME DP - Unbound Medicine ER -