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The hypocholesterolemic and hormone modulation effects of isoflavones alone or co-fermented with probiotic bacteria in hypercholesterolemic rats model.

Abstract

This study aimed to investigate the beneficial effect of isoflavones alone or probiotics-co-fermented isoflavones on serum and hepatic lipid profile, serum steroid (SHs) and thyroid hormones (THs) of hypercholesterolemic rats (N = 48). Animals were fed for 8 weeks with probiotics-co-fermented isoflavones or isoflavones alone, beside high-fat-high-cholesterol diet. Serum was analyzed for cholesterols, triglycerides (TG), SHs and THs. Results demonstrated that the given treatments significantly decreased serum total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), LDL/HDL ratio, and increased TG, compared to controls. The probiotics-co-fermented isoflavones decreased TC, LDL-C and LDL/HDL ratio more effectively than isoflavones alone. Also, both isoflavones treatments induced a hyperthyroidism state, as the levels of T-T4, T-T3 and fT3 significantly increased. In addition, these treatments decreased testosterone and increased cortisol levels. Thus, isoflavones-containing-treatments, particularly probiotics-co-fermented isoflavones, could reduce CVD incidence by controlling lipid profile; and this control could in part be due to modulation of SHs and THs.

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  • Authors+Show Affiliations

    ,

    Faculty of Agriculture, Jordan University of Science and Technology , Irbid , Jordan .

    , ,

    Source

    MeSH

    Animals
    Anticholesteremic Agents
    Bacteria
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Diet, High-Fat
    Disease Models, Animal
    Fermentation
    Hydrocortisone
    Hypercholesterolemia
    Isoflavones
    Liver
    Male
    Plant Extracts
    Probiotics
    Rats, Sprague-Dawley
    Steroids
    Testosterone
    Thyroid Hormones
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25853701

    Citation

    Rababah, Taha M., et al. "The Hypocholesterolemic and Hormone Modulation Effects of Isoflavones Alone or Co-fermented With Probiotic Bacteria in Hypercholesterolemic Rats Model." International Journal of Food Sciences and Nutrition, vol. 66, no. 5, 2015, pp. 546-52.
    Rababah TM, Awaisheh SS, Al-Tamimi HJ, et al. The hypocholesterolemic and hormone modulation effects of isoflavones alone or co-fermented with probiotic bacteria in hypercholesterolemic rats model. Int J Food Sci Nutr. 2015;66(5):546-52.
    Rababah, T. M., Awaisheh, S. S., Al-Tamimi, H. J., & Brewer, S. (2015). The hypocholesterolemic and hormone modulation effects of isoflavones alone or co-fermented with probiotic bacteria in hypercholesterolemic rats model. International Journal of Food Sciences and Nutrition, 66(5), pp. 546-52. doi:10.3109/09637486.2015.1028908.
    Rababah TM, et al. The Hypocholesterolemic and Hormone Modulation Effects of Isoflavones Alone or Co-fermented With Probiotic Bacteria in Hypercholesterolemic Rats Model. Int J Food Sci Nutr. 2015;66(5):546-52. PubMed PMID: 25853701.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The hypocholesterolemic and hormone modulation effects of isoflavones alone or co-fermented with probiotic bacteria in hypercholesterolemic rats model. AU - Rababah,Taha M, AU - Awaisheh,Saddam S, AU - Al-Tamimi,Hosam J, AU - Brewer,Susan, Y1 - 2015/04/08/ PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2016/5/3/medline KW - Hypercholesterolemia KW - isoflavones KW - probiotics KW - steroids KW - symbiotic KW - thyroid SP - 546 EP - 52 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 66 IS - 5 N2 - This study aimed to investigate the beneficial effect of isoflavones alone or probiotics-co-fermented isoflavones on serum and hepatic lipid profile, serum steroid (SHs) and thyroid hormones (THs) of hypercholesterolemic rats (N = 48). Animals were fed for 8 weeks with probiotics-co-fermented isoflavones or isoflavones alone, beside high-fat-high-cholesterol diet. Serum was analyzed for cholesterols, triglycerides (TG), SHs and THs. Results demonstrated that the given treatments significantly decreased serum total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), LDL/HDL ratio, and increased TG, compared to controls. The probiotics-co-fermented isoflavones decreased TC, LDL-C and LDL/HDL ratio more effectively than isoflavones alone. Also, both isoflavones treatments induced a hyperthyroidism state, as the levels of T-T4, T-T3 and fT3 significantly increased. In addition, these treatments decreased testosterone and increased cortisol levels. Thus, isoflavones-containing-treatments, particularly probiotics-co-fermented isoflavones, could reduce CVD incidence by controlling lipid profile; and this control could in part be due to modulation of SHs and THs. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/25853701/The_hypocholesterolemic_and_hormone_modulation_effects_of_isoflavones_alone_or_co_fermented_with_probiotic_bacteria_in_hypercholesterolemic_rats_model_ L2 - http://www.tandfonline.com/doi/full/10.3109/09637486.2015.1028908 DB - PRIME DP - Unbound Medicine ER -