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Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats.
Pharm Biol. 2015; 53(9):1372-8.PB

Abstract

CONTEXT

Kaempferol is a flavonoid found in many edible plants (e.g. tea, cabbage, beans, tomato, strawberries, and grapes) and in plants or botanical products commonly used in traditional medicine. Numerous preclinical studies have shown that kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, and antidiabetic activities.

OBJECTIVE

The present study investigates the effect of kaempferol on membrane-bound ATPases in erythrocytes and in liver, kidney, and heart of streptozotocin (STZ)-induced diabetic rats.

MATERIALS AND METHODS

Diabetes was induced into adult male albino rats of the Wistar strain, by intraperitoneal administration of STZ (40 mg/kg body weight (BW)). Kaempferol (100 mg/kg BW) or glibenclamide (600 µg/kg BW) was administered orally once daily for 45 d to normal and STZ-induced diabetic rats. The effects of kaempferol on membrane-bound ATPases (total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase, and Mg(2+)-ATPase) activity in erythrocytes and in liver, kidney, and heart were determined.

RESULTS

In our study, diabetic rats had significantly (p < 0.05) decreased activities of total ATPases, Na(+)/K(+)-ATPase, Ca(2+)-ATPase, and Mg(2+)-ATPase in erythrocytes and tissues. Oral administration of kaempferol (100 mg/kg BW) or glibenclamide (600 µg/kg BW) for a period of 45 d resulted in significant (p < 0.05) reversal of these enzymes' activities to near normal in erythrocytes and tissues when compared with diabetic control rats.

DISCUSSION AND CONCLUSION

Thus, obtained results indicate that administration of kaempferol has the potential to restore deranged activity of membrane-bound ATPases in STZ-induced diabetic rats. Further detailed investigation is necessary to discover kaempferol's action mechanism.

Authors+Show Affiliations

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25853957

Citation

Al-Numair, Khalid S., et al. "Influence of Kaempferol, a Flavonoid Compound, On Membrane-bound ATPases in Streptozotocin-induced Diabetic Rats." Pharmaceutical Biology, vol. 53, no. 9, 2015, pp. 1372-8.
Al-Numair KS, Veeramani C, Alsaif MA, et al. Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats. Pharm Biol. 2015;53(9):1372-8.
Al-Numair, K. S., Veeramani, C., Alsaif, M. A., & Chandramohan, G. (2015). Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 53(9), 1372-8. https://doi.org/10.3109/13880209.2014.982301
Al-Numair KS, et al. Influence of Kaempferol, a Flavonoid Compound, On Membrane-bound ATPases in Streptozotocin-induced Diabetic Rats. Pharm Biol. 2015;53(9):1372-8. PubMed PMID: 25853957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats. AU - Al-Numair,Khalid S, AU - Veeramani,Chinnadurai, AU - Alsaif,Mohammed A, AU - Chandramohan,Govindasamy, Y1 - 2015/04/08/ PY - 2015/4/9/entrez PY - 2015/4/9/pubmed PY - 2016/4/12/medline KW - Albino Wistar rats KW - Ca2+-ATPase KW - Mg2+-ATPase KW - Na+/K+-ATPase KW - diabetes KW - total ATPase SP - 1372 EP - 8 JF - Pharmaceutical biology JO - Pharm Biol VL - 53 IS - 9 N2 - CONTEXT: Kaempferol is a flavonoid found in many edible plants (e.g. tea, cabbage, beans, tomato, strawberries, and grapes) and in plants or botanical products commonly used in traditional medicine. Numerous preclinical studies have shown that kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, and antidiabetic activities. OBJECTIVE: The present study investigates the effect of kaempferol on membrane-bound ATPases in erythrocytes and in liver, kidney, and heart of streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetes was induced into adult male albino rats of the Wistar strain, by intraperitoneal administration of STZ (40 mg/kg body weight (BW)). Kaempferol (100 mg/kg BW) or glibenclamide (600 µg/kg BW) was administered orally once daily for 45 d to normal and STZ-induced diabetic rats. The effects of kaempferol on membrane-bound ATPases (total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase, and Mg(2+)-ATPase) activity in erythrocytes and in liver, kidney, and heart were determined. RESULTS: In our study, diabetic rats had significantly (p < 0.05) decreased activities of total ATPases, Na(+)/K(+)-ATPase, Ca(2+)-ATPase, and Mg(2+)-ATPase in erythrocytes and tissues. Oral administration of kaempferol (100 mg/kg BW) or glibenclamide (600 µg/kg BW) for a period of 45 d resulted in significant (p < 0.05) reversal of these enzymes' activities to near normal in erythrocytes and tissues when compared with diabetic control rats. DISCUSSION AND CONCLUSION: Thus, obtained results indicate that administration of kaempferol has the potential to restore deranged activity of membrane-bound ATPases in STZ-induced diabetic rats. Further detailed investigation is necessary to discover kaempferol's action mechanism. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/25853957/Influence_of_kaempferol_a_flavonoid_compound_on_membrane_bound_ATPases_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2014.982301 DB - PRIME DP - Unbound Medicine ER -