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The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index.
Acta Odontol Scand. 2015; 73(8):633-41.AO

Abstract

SUMMARY

Leptin concentrations are altered in favour of pro health after periodontal therapy.

BACKGROUND

Leptin, a non-glycosylated peptide hormone, not only maintains fat stores, but is also an integral part of host defense repertoire. Leptin levels have been found to be altered in an array of inflammatory diseases including chronic periodontitis (CP), but the role of non-surgical periodontal therapy (NSPT) in altering the leptin concentrations in saliva and serum of CP patients is yet to be ascertained. The aim of the present study is to quantify leptin levels in CP patients having normal body mass index (BMI) pre-therapy as compared to periodontally healthy controls and to address whether successful NSPT alters leptin concentration in serum and saliva.

MATERIALS AND METHODS

Twenty-two saliva (modified draining method) and serum samples (by venipuncture) were collected from CP patients with normal BMI (n = 22), before and at 4 and 12 weeks after completion of NSPT, and periodontally healthy, age- and gender-matched controls (n = 22). Leptin levels were estimated using enzyme linked immunosorbent assay kits.

RESULTS

At baseline, CP patients had significantly different periodontal clinical parameters and the leptin concentrations in saliva of CP patients were found to be significantly lower than periodontally healthy volunteers (4710.10 ± 1133.21 vs 8721.10 ± 1019.58 pg/ml) (p < 0.05), whereas in serum the leptin concentrations were significantly higher than healthy controls (10749 ± 2062.24 vs 8085.00 ± 2859.68 pg/ml). Significant improvement in periodontal parameters, serum and salivary leptin levels were observed in CP patients at 4 and 12 weeks post-therapy (p < 0.01).

CONCLUSION

Altered concentrations of leptin in serum and saliva are observed in CP patients which can be restored in favor of health after periodontal therapy.

Authors+Show Affiliations

Department of Periodontology, Faculty of Dental Sciences, King George's Medical University , Lucknow, Uttar Pradesh , India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Study
Comparative Study
Journal Article

Language

eng

PubMed ID

25854413

Citation

Purwar, Parth, et al. "The Effects of Periodontal Therapy On Serum and Salivary Leptin Levels in Chronic Periodontitis Patients With Normal Body Mass Index." Acta Odontologica Scandinavica, vol. 73, no. 8, 2015, pp. 633-41.
Purwar P, Khan MA, Gupta A, et al. The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index. Acta Odontol Scand. 2015;73(8):633-41.
Purwar, P., Khan, M. A., Gupta, A., Mahdi, A. A., Pandey, S., Singh, B., Dixit, J., & Rai, P. (2015). The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index. Acta Odontologica Scandinavica, 73(8), 633-41. https://doi.org/10.3109/00016357.2015.1030768
Purwar P, et al. The Effects of Periodontal Therapy On Serum and Salivary Leptin Levels in Chronic Periodontitis Patients With Normal Body Mass Index. Acta Odontol Scand. 2015;73(8):633-41. PubMed PMID: 25854413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index. AU - Purwar,Parth, AU - Khan,Mohammed Akhlaq, AU - Gupta,Abhishek, AU - Mahdi,Abbas Ali, AU - Pandey,Shivani, AU - Singh,Babita, AU - Dixit,Jaya, AU - Rai,Priya, Y1 - 2015/04/08/ PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/2/13/medline KW - Cardiovascular disease KW - leptin KW - non-surgical periodontal therapy KW - periodontitis KW - saliva KW - serum SP - 633 EP - 41 JF - Acta odontologica Scandinavica JO - Acta Odontol. Scand. VL - 73 IS - 8 N2 - SUMMARY: Leptin concentrations are altered in favour of pro health after periodontal therapy. BACKGROUND: Leptin, a non-glycosylated peptide hormone, not only maintains fat stores, but is also an integral part of host defense repertoire. Leptin levels have been found to be altered in an array of inflammatory diseases including chronic periodontitis (CP), but the role of non-surgical periodontal therapy (NSPT) in altering the leptin concentrations in saliva and serum of CP patients is yet to be ascertained. The aim of the present study is to quantify leptin levels in CP patients having normal body mass index (BMI) pre-therapy as compared to periodontally healthy controls and to address whether successful NSPT alters leptin concentration in serum and saliva. MATERIALS AND METHODS: Twenty-two saliva (modified draining method) and serum samples (by venipuncture) were collected from CP patients with normal BMI (n = 22), before and at 4 and 12 weeks after completion of NSPT, and periodontally healthy, age- and gender-matched controls (n = 22). Leptin levels were estimated using enzyme linked immunosorbent assay kits. RESULTS: At baseline, CP patients had significantly different periodontal clinical parameters and the leptin concentrations in saliva of CP patients were found to be significantly lower than periodontally healthy volunteers (4710.10 ± 1133.21 vs 8721.10 ± 1019.58 pg/ml) (p < 0.05), whereas in serum the leptin concentrations were significantly higher than healthy controls (10749 ± 2062.24 vs 8085.00 ± 2859.68 pg/ml). Significant improvement in periodontal parameters, serum and salivary leptin levels were observed in CP patients at 4 and 12 weeks post-therapy (p < 0.01). CONCLUSION: Altered concentrations of leptin in serum and saliva are observed in CP patients which can be restored in favor of health after periodontal therapy. SN - 1502-3850 UR - https://www.unboundmedicine.com/medline/citation/25854413/The_effects_of_periodontal_therapy_on_serum_and_salivary_leptin_levels_in_chronic_periodontitis_patients_with_normal_body_mass_index_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016357.2015.1030768 DB - PRIME DP - Unbound Medicine ER -