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Meta-analysis of the association between vitamin D and autoimmune thyroid disease.
Nutrients. 2015 Apr 03; 7(4):2485-98.N

Abstract

Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. wangjiying90@aliyun.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. lss219219@163.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. terry1210@aliyun.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. gaochenlin00@126.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. hyjx88@163.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. zhh-302102@163.com.Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. xywyll@aliyun.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25854833

Citation

Wang, Jiying, et al. "Meta-analysis of the Association Between Vitamin D and Autoimmune Thyroid Disease." Nutrients, vol. 7, no. 4, 2015, pp. 2485-98.
Wang J, Lv S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015;7(4):2485-98.
Wang, J., Lv, S., Chen, G., Gao, C., He, J., Zhong, H., & Xu, Y. (2015). Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients, 7(4), 2485-98. https://doi.org/10.3390/nu7042485
Wang J, et al. Meta-analysis of the Association Between Vitamin D and Autoimmune Thyroid Disease. Nutrients. 2015 Apr 3;7(4):2485-98. PubMed PMID: 25854833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of the association between vitamin D and autoimmune thyroid disease. AU - Wang,Jiying, AU - Lv,Shishi, AU - Chen,Guo, AU - Gao,Chenlin, AU - He,Jianhua, AU - Zhong,Haihua, AU - Xu,Yong, Y1 - 2015/04/03/ PY - 2015/01/15/received PY - 2015/02/10/revised PY - 2015/03/16/accepted PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/1/31/medline SP - 2485 EP - 98 JF - Nutrients JO - Nutrients VL - 7 IS - 4 N2 - Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/25854833/Meta_analysis_of_the_association_between_vitamin_D_and_autoimmune_thyroid_disease_ L2 - http://www.mdpi.com/resolver?pii=nu7042485 DB - PRIME DP - Unbound Medicine ER -