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Administration of fenoldopam in critically ill small animal patients with acute kidney injury: 28 dogs and 34 cats (2008-2012).
J Vet Emerg Crit Care (San Antonio) 2015 May-Jun; 25(3):396-404JV

Abstract

OBJECTIVE

To describe the clinical features and outcomes of critically ill dogs and cats with acute kidney injury (AKI) receiving fenoldopam infusions compared to patients with AKI that did not receive fenoldopam.

DESIGN

Retrospective clinical study from May 1, 2008 until June 1, 2012.

SETTING

Private emergency and specialty referral hospital.

ANIMALS

Client-owned dogs (28) and cats (34) with AKI that received fenoldopam compared with similar patients with AKI (30 dogs and 30 cats) that did not.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

The medical records of 62 critically ill dogs and cats with AKI that received fenoldopam were reviewed. Presenting clinical signs, physical examination findings, and primary and secondary disease processes were identified in all patients. The mean number of days on fenoldopam was 1.5 days (range 0.3-4.0 days) for dogs and 1.9 days (range 1.0-4.0 days) for cats. Eleven of 28 (39%) dogs survived to discharge and 13 of 34 (38%) of the cats survived to discharge. Of the animals in the group receiving fenoldopam that died, the majority (84%) were euthanized. Potential adverse reactions were evaluated, with hypotension being the most commonly encountered adverse effect (7% of fenoldopam group [FG] dogs and 23% of FG cats). When compared with patients with AKI that did not receive fenoldopam, no significant differences were found between the groups with regards to survival, length of hospital stay, adverse effects, or changes in creatinine, BUN, or sodium concentrations except that patients receiving fenoldopam were significantly more likely to have received other renally active medications.

CONCLUSIONS

In this study of patients with AKI, fenoldopam administration at 0.8 μg/kg/min in dogs and 0.5 μg/kg/min in cats appeared relatively safe but was not associated with improvement in survival to discharge, length of hospital stay, or improvement in renal biochemical parameters when compared to patients with AKI not receiving fenoldopam.

Authors+Show Affiliations

Angell Animal Medical Center, Boston, MA.Angell Animal Medical Center, Boston, MA.Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

25854861

Citation

Nielsen, Lindsey K., et al. "Administration of Fenoldopam in Critically Ill Small Animal Patients With Acute Kidney Injury: 28 Dogs and 34 Cats (2008-2012)." Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), vol. 25, no. 3, 2015, pp. 396-404.
Nielsen LK, Bracker K, Price LL. Administration of fenoldopam in critically ill small animal patients with acute kidney injury: 28 dogs and 34 cats (2008-2012). J Vet Emerg Crit Care (San Antonio). 2015;25(3):396-404.
Nielsen, L. K., Bracker, K., & Price, L. L. (2015). Administration of fenoldopam in critically ill small animal patients with acute kidney injury: 28 dogs and 34 cats (2008-2012). Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 25(3), pp. 396-404. doi:10.1111/vec.12303.
Nielsen LK, Bracker K, Price LL. Administration of Fenoldopam in Critically Ill Small Animal Patients With Acute Kidney Injury: 28 Dogs and 34 Cats (2008-2012). J Vet Emerg Crit Care (San Antonio). 2015;25(3):396-404. PubMed PMID: 25854861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of fenoldopam in critically ill small animal patients with acute kidney injury: 28 dogs and 34 cats (2008-2012). AU - Nielsen,Lindsey K, AU - Bracker,Kiko, AU - Price,Lori Lyn, Y1 - 2015/04/08/ PY - 2012/12/19/received PY - 2015/01/26/accepted PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/4/19/medline KW - AKI KW - acute renal failure KW - anuria KW - canine KW - feline KW - oliguria SP - 396 EP - 404 JF - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) JO - J Vet Emerg Crit Care (San Antonio) VL - 25 IS - 3 N2 - OBJECTIVE: To describe the clinical features and outcomes of critically ill dogs and cats with acute kidney injury (AKI) receiving fenoldopam infusions compared to patients with AKI that did not receive fenoldopam. DESIGN: Retrospective clinical study from May 1, 2008 until June 1, 2012. SETTING: Private emergency and specialty referral hospital. ANIMALS: Client-owned dogs (28) and cats (34) with AKI that received fenoldopam compared with similar patients with AKI (30 dogs and 30 cats) that did not. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The medical records of 62 critically ill dogs and cats with AKI that received fenoldopam were reviewed. Presenting clinical signs, physical examination findings, and primary and secondary disease processes were identified in all patients. The mean number of days on fenoldopam was 1.5 days (range 0.3-4.0 days) for dogs and 1.9 days (range 1.0-4.0 days) for cats. Eleven of 28 (39%) dogs survived to discharge and 13 of 34 (38%) of the cats survived to discharge. Of the animals in the group receiving fenoldopam that died, the majority (84%) were euthanized. Potential adverse reactions were evaluated, with hypotension being the most commonly encountered adverse effect (7% of fenoldopam group [FG] dogs and 23% of FG cats). When compared with patients with AKI that did not receive fenoldopam, no significant differences were found between the groups with regards to survival, length of hospital stay, adverse effects, or changes in creatinine, BUN, or sodium concentrations except that patients receiving fenoldopam were significantly more likely to have received other renally active medications. CONCLUSIONS: In this study of patients with AKI, fenoldopam administration at 0.8 μg/kg/min in dogs and 0.5 μg/kg/min in cats appeared relatively safe but was not associated with improvement in survival to discharge, length of hospital stay, or improvement in renal biochemical parameters when compared to patients with AKI not receiving fenoldopam. SN - 1476-4431 UR - https://www.unboundmedicine.com/medline/citation/25854861/Administration_of_fenoldopam_in_critically_ill_small_animal_patients_with_acute_kidney_injury:_28_dogs_and_34_cats__2008_2012__ L2 - https://doi.org/10.1111/vec.12303 DB - PRIME DP - Unbound Medicine ER -