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Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses.
J Alzheimers Dis. 2015; 46(3):777-90.JA

Abstract

The associations between homocysteine (Hcy), folic acid, and vitamin B12 and Alzheimer's disease (AD) have gained much interest, while remaining controversial. We aim to perform meta-analyses to evaluate comprehensively: i) Hcy, folic acid, and vitamin B12 levels in AD patients in comparison with controls; and ii) the association between Hcy, folic acid, and vitamin B12 levels and risk of AD. A literature search was performed using Medline and Scopus databases. A total of 68 studies were identified and included in the meta-analyses. Stata 12.0 statistical software was used to perform the meta-analyses. First, AD patients may have higher level of Hcy, and lower levels of folate and vitamin B12 in plasma than controls. Further age-subgroup analysis showed no age effect for Hcy levels in plasma between AD patients and matched controls, while the differences in folate and vitamin B12 levels further enlarged with increased age. Second, data suggests that high Hcy and low folate levels may correlate with increased risk of AD occurrence. The comprehensive meta-analyses not only confirmed higher Hcy, lower folic acid, and vitamin B12 levels in AD patients than controls, but also implicated that high Hcy and low folic acid levels may be risk factors of AD. Further studies are encouraged to elucidate mechanisms linking these conditions.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25854931

Citation

Shen, Liang, and Hong-Fang Ji. "Associations Between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights From Meta-Analyses." Journal of Alzheimer's Disease : JAD, vol. 46, no. 3, 2015, pp. 777-90.
Shen L, Ji HF. Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses. J Alzheimers Dis. 2015;46(3):777-90.
Shen, L., & Ji, H. F. (2015). Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses. Journal of Alzheimer's Disease : JAD, 46(3), 777-90. https://doi.org/10.3233/JAD-150140
Shen L, Ji HF. Associations Between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights From Meta-Analyses. J Alzheimers Dis. 2015;46(3):777-90. PubMed PMID: 25854931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses. AU - Shen,Liang, AU - Ji,Hong-Fang, PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/6/28/medline KW - Alzheimer’s disease KW - folic acid KW - homocysteine KW - meta-analysis KW - vitamin B12 SP - 777 EP - 90 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 46 IS - 3 N2 - The associations between homocysteine (Hcy), folic acid, and vitamin B12 and Alzheimer's disease (AD) have gained much interest, while remaining controversial. We aim to perform meta-analyses to evaluate comprehensively: i) Hcy, folic acid, and vitamin B12 levels in AD patients in comparison with controls; and ii) the association between Hcy, folic acid, and vitamin B12 levels and risk of AD. A literature search was performed using Medline and Scopus databases. A total of 68 studies were identified and included in the meta-analyses. Stata 12.0 statistical software was used to perform the meta-analyses. First, AD patients may have higher level of Hcy, and lower levels of folate and vitamin B12 in plasma than controls. Further age-subgroup analysis showed no age effect for Hcy levels in plasma between AD patients and matched controls, while the differences in folate and vitamin B12 levels further enlarged with increased age. Second, data suggests that high Hcy and low folate levels may correlate with increased risk of AD occurrence. The comprehensive meta-analyses not only confirmed higher Hcy, lower folic acid, and vitamin B12 levels in AD patients than controls, but also implicated that high Hcy and low folic acid levels may be risk factors of AD. Further studies are encouraged to elucidate mechanisms linking these conditions. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25854931/Associations_between_Homocysteine_Folic_Acid_Vitamin_B12_and_Alzheimer's_Disease:_Insights_from_Meta_Analyses_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-150140 DB - PRIME DP - Unbound Medicine ER -