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Primary intraosseous ganglioneuromatous paraganglioma of the sacrum with immunopositivity for cytokeratin.
Eur Rev Med Pharmacol Sci. 2015; 19(6):931-5.ER

Abstract

BACKGROUND

Paragangliomas are derived from neurosecretory cells believed to be of neural crest origin. A spinal location of paraganglioma is rare and usually presents as an intradural mass.

PATIENT AND METHODS

A primary intraosseous paraganglioma of sacrum is extremely unusual, and only 6 cases were reported. In this study, we report a rare case of a 44-year-old man with the complaint of low back pain and lower extremity weakness. Imaging workup, including computerized tomography (CT), and magnetic resonance imaging (MRI) presented an intraosseous sacral lesion with invasion of sacrum in the S1-S3 vertebrae, and extension to L4-L5 spinal canal. The patient underwent subtotal tumor resection, followed by radiation therapy.

RESULTS

The morphological and immunohistochemical studies revealed a composite tumor of paraganglioma and ganglioneuroma components, with immunopositivity for cytokeratin.

CONCLUSIONS

To the best of our knowledge, this is the first report in the literature demonstrating an intraosseous sacral paraganglioma with these 2 pathological features.

Authors+Show Affiliations

Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong, P.R. China. 18753157528@163.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25855915

Citation

Wu, C-S, et al. "Primary Intraosseous Ganglioneuromatous Paraganglioma of the Sacrum With Immunopositivity for Cytokeratin." European Review for Medical and Pharmacological Sciences, vol. 19, no. 6, 2015, pp. 931-5.
Wu CS, Wang XW, Qin T, et al. Primary intraosseous ganglioneuromatous paraganglioma of the sacrum with immunopositivity for cytokeratin. Eur Rev Med Pharmacol Sci. 2015;19(6):931-5.
Wu, C. S., Wang, X. W., Qin, T., Chen, Z., Sun, S., Li, J. M., Liu, H. L., Feng, H., & Han, J. Q. (2015). Primary intraosseous ganglioneuromatous paraganglioma of the sacrum with immunopositivity for cytokeratin. European Review for Medical and Pharmacological Sciences, 19(6), 931-5.
Wu CS, et al. Primary Intraosseous Ganglioneuromatous Paraganglioma of the Sacrum With Immunopositivity for Cytokeratin. Eur Rev Med Pharmacol Sci. 2015;19(6):931-5. PubMed PMID: 25855915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary intraosseous ganglioneuromatous paraganglioma of the sacrum with immunopositivity for cytokeratin. AU - Wu,C-S, AU - Wang,X-W, AU - Qin,T, AU - Chen,Z, AU - Sun,S, AU - Li,J-M, AU - Liu,H-L, AU - Feng,H, AU - Han,J-Q, PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2015/11/17/medline SP - 931 EP - 5 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 19 IS - 6 N2 - BACKGROUND: Paragangliomas are derived from neurosecretory cells believed to be of neural crest origin. A spinal location of paraganglioma is rare and usually presents as an intradural mass. PATIENT AND METHODS: A primary intraosseous paraganglioma of sacrum is extremely unusual, and only 6 cases were reported. In this study, we report a rare case of a 44-year-old man with the complaint of low back pain and lower extremity weakness. Imaging workup, including computerized tomography (CT), and magnetic resonance imaging (MRI) presented an intraosseous sacral lesion with invasion of sacrum in the S1-S3 vertebrae, and extension to L4-L5 spinal canal. The patient underwent subtotal tumor resection, followed by radiation therapy. RESULTS: The morphological and immunohistochemical studies revealed a composite tumor of paraganglioma and ganglioneuroma components, with immunopositivity for cytokeratin. CONCLUSIONS: To the best of our knowledge, this is the first report in the literature demonstrating an intraosseous sacral paraganglioma with these 2 pathological features. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/25855915/Primary_intraosseous_ganglioneuromatous_paraganglioma_of_the_sacrum_with_immunopositivity_for_cytokeratin_ L2 - http://www.europeanreview.org/article/8667 DB - PRIME DP - Unbound Medicine ER -