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Association between alcohol consumption and pancreatic cancer risk: a case-control study.

Abstract

PURPOSE

Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk.

METHODS

A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction.

RESULTS

Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers.

CONCLUSIONS

While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained.

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  • Authors+Show Affiliations

    ,

    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

    ,

    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.

    ,

    Department of Surgery, University Health Network, Toronto, Ontario, Canada; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.

    Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of General Surgery, Toronto General Hospital, Toronto, Ontario, Canada.

    Source

    PloS one 10:4 2015 pg e0124489

    MeSH

    Alcohol Drinking
    Case-Control Studies
    Humans
    Logistic Models
    Odds Ratio
    Ontario
    Pancreatic Neoplasms
    Risk Factors
    Sex Factors
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25856529

    Citation

    Rahman, Farah, et al. "Association Between Alcohol Consumption and Pancreatic Cancer Risk: a Case-control Study." PloS One, vol. 10, no. 4, 2015, pp. e0124489.
    Rahman F, Cotterchio M, Cleary SP, et al. Association between alcohol consumption and pancreatic cancer risk: a case-control study. PLoS ONE. 2015;10(4):e0124489.
    Rahman, F., Cotterchio, M., Cleary, S. P., & Gallinger, S. (2015). Association between alcohol consumption and pancreatic cancer risk: a case-control study. PloS One, 10(4), pp. e0124489. doi:10.1371/journal.pone.0124489.
    Rahman F, et al. Association Between Alcohol Consumption and Pancreatic Cancer Risk: a Case-control Study. PLoS ONE. 2015;10(4):e0124489. PubMed PMID: 25856529.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between alcohol consumption and pancreatic cancer risk: a case-control study. AU - Rahman,Farah, AU - Cotterchio,Michelle, AU - Cleary,Sean P, AU - Gallinger,Steven, Y1 - 2015/04/09/ PY - 2015/01/15/received PY - 2015/03/03/accepted PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/3/29/medline SP - e0124489 EP - e0124489 JF - PloS one JO - PLoS ONE VL - 10 IS - 4 N2 - PURPOSE: Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk. METHODS: A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction. RESULTS: Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers. CONCLUSIONS: While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25856529/Association_between_alcohol_consumption_and_pancreatic_cancer_risk:_a_case_control_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0124489 DB - PRIME DP - Unbound Medicine ER -