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Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species.
Pharm Biol 2015; 53(9):1267-76PB

Abstract

CONTEXT

Vismia cauliflora A.C.Sm. [Hypericaceae (Clusiaceae)] is a plant from Amazonian forest. It is used by Amerindians to treat dermatosis and inflammatory processes in the skin and has been considered an interesting source of bioactive compounds.

OBJECTIVE

We evaluated the scavenging capacity of extracts from V. cauliflora (leaf, branch, stem bark, flower, and whole fruit) against reactive oxygen (ROS) and nitrogen species (RNS), namely, superoxide radical ([Formula: see text]), hydrogen peroxide (H2O2), hypochlorous acid (HOCl), singlet oxygen ((1)O2), nitric oxide ((•)NO), and peroxynitrite (ONOO(-)). In addition, for the first time, the profile of phenolic compounds and carotenoids was determined.

MATERIALS AND METHODS

The scavenging capacities of each extract were determined using specific probes (fluorescent, colorimetric, and chemiluminescent) to detect different reactive species ((1)O2, HOCl, H2O2, [Formula: see text], (•)NO, and ONOO(-)). The identification and the quantification of phenolic compounds and carotenoids were carried out by HPLC-DAD-ESI-MS/MS and HPLC-DAD, respectively.

RESULTS

(-)-Epicatechin and proanthocyanidin dimers and trimer were the major phenolic compounds tentatively identified in leaf, branch, stem bark, and flower extracts, while dihydroxybenzoic acids were the major compounds in whole fruit extracts. All-trans-zeinoxanthin and all-trans-β-carotene were the major carotenoids tentatively identified in leaf extracts. All extracts of V. cauliflora showed high efficiency against all tested ROS and RNS, although flower and stem bark extracts exhibited the most remarkable scavenging capacity, especially for (•)NO and ONOO(-).

DISCUSSION AND CONCLUSION

Vismia cauliflora has great potential to be used in the development of phytopharmaceutical products due to its characteristic of being a promising source of bioactive compounds with high antioxidant properties.

Authors+Show Affiliations

PosGraduate Program of Food Science and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25856696

Citation

Ribeiro, Alessandra Braga, et al. "Bioactive Compounds and Scavenging Capacity of Extracts From Different Parts of Vismia Cauliflora Against Reactive Oxygen and Nitrogen Species." Pharmaceutical Biology, vol. 53, no. 9, 2015, pp. 1267-76.
Ribeiro AB, Berto A, Chisté RC, et al. Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species. Pharm Biol. 2015;53(9):1267-76.
Ribeiro, A. B., Berto, A., Chisté, R. C., Freitas, M., Visentainer, J. V., & Fernandes, E. (2015). Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species. Pharmaceutical Biology, 53(9), pp. 1267-76. doi:10.3109/13880209.2014.974063.
Ribeiro AB, et al. Bioactive Compounds and Scavenging Capacity of Extracts From Different Parts of Vismia Cauliflora Against Reactive Oxygen and Nitrogen Species. Pharm Biol. 2015;53(9):1267-76. PubMed PMID: 25856696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species. AU - Ribeiro,Alessandra Braga, AU - Berto,Alessandra, AU - Chisté,Renan Campos, AU - Freitas,Marisa, AU - Visentainer,Jesuí V, AU - Fernandes,Eduarda, Y1 - 2015/04/09/ PY - 2015/4/10/entrez PY - 2015/4/10/pubmed PY - 2016/4/12/medline KW - Amazonian plant KW - LC-MS KW - antioxidant capacity, carotenoids KW - phenolic compounds SP - 1267 EP - 76 JF - Pharmaceutical biology JO - Pharm Biol VL - 53 IS - 9 N2 - CONTEXT: Vismia cauliflora A.C.Sm. [Hypericaceae (Clusiaceae)] is a plant from Amazonian forest. It is used by Amerindians to treat dermatosis and inflammatory processes in the skin and has been considered an interesting source of bioactive compounds. OBJECTIVE: We evaluated the scavenging capacity of extracts from V. cauliflora (leaf, branch, stem bark, flower, and whole fruit) against reactive oxygen (ROS) and nitrogen species (RNS), namely, superoxide radical ([Formula: see text]), hydrogen peroxide (H2O2), hypochlorous acid (HOCl), singlet oxygen ((1)O2), nitric oxide ((•)NO), and peroxynitrite (ONOO(-)). In addition, for the first time, the profile of phenolic compounds and carotenoids was determined. MATERIALS AND METHODS: The scavenging capacities of each extract were determined using specific probes (fluorescent, colorimetric, and chemiluminescent) to detect different reactive species ((1)O2, HOCl, H2O2, [Formula: see text], (•)NO, and ONOO(-)). The identification and the quantification of phenolic compounds and carotenoids were carried out by HPLC-DAD-ESI-MS/MS and HPLC-DAD, respectively. RESULTS: (-)-Epicatechin and proanthocyanidin dimers and trimer were the major phenolic compounds tentatively identified in leaf, branch, stem bark, and flower extracts, while dihydroxybenzoic acids were the major compounds in whole fruit extracts. All-trans-zeinoxanthin and all-trans-β-carotene were the major carotenoids tentatively identified in leaf extracts. All extracts of V. cauliflora showed high efficiency against all tested ROS and RNS, although flower and stem bark extracts exhibited the most remarkable scavenging capacity, especially for (•)NO and ONOO(-). DISCUSSION AND CONCLUSION: Vismia cauliflora has great potential to be used in the development of phytopharmaceutical products due to its characteristic of being a promising source of bioactive compounds with high antioxidant properties. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/25856696/Bioactive_compounds_and_scavenging_capacity_of_extracts_from_different_parts_of_Vismia_cauliflora_against_reactive_oxygen_and_nitrogen_species_ L2 - http://www.tandfonline.com/doi/full/10.3109/13880209.2014.974063 DB - PRIME DP - Unbound Medicine ER -