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Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome.
Hum Reprod. 2015 Jun; 30(6):1358-64.HR

Abstract

STUDY QUESTION

Are certain ethnic groups with polycystic ovary syndrome (PCOS) at increased risk of metabolic disorders?

SUMMARY ANSWER

Obese Hispanic women with PCOS are at increased risk of metabolic disorders compared with age- and BMI-matched obese non-Hispanic white women with PCOS in the USA.

WHAT IS KNOWN ALREADY

Ethnic differences in body composition and metabolic risk are well established. PCOS is a common disorder in women of reproductive age and is associated with high rates of insulin resistance, glucose intolerance and dyslipidemia.

STUDY DESIGN, SIZE, DURATION

A cross-sectional observational study was performed at an Academic Medical Center on 60 women of reproductive age with PCOS.

PARTICIPANTS/MATERIALS, SETTING, METHODS

Blood was obtained after fasting from 17 Hispanic, 22 non-Hispanic black and 21 non-Hispanic white women with PCOS who were similar in age and BMI. Anthropometric parameters, insulin, lipid and lipoprotein levels (measured by nuclear magnetic resonance) were compared between the three groups.

MAIN RESULTS AND THE ROLE OF CHANCE

Age and BMI did not differ between the groups. Hispanic women with PCOS had higher waist-to-hip ratio (WHR) (P = 0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.03) and a more atherogenic lipid and lipoprotein profile consisting of lower high-density lipoprotein (HDL) (P = 0.02), higher low-density lipoprotein (LDL) particle number (P = 0.02), higher very low-density lipoprotein particle (VLDL) size (P = 0.03) and lower LDL (P = 0.03) and HDL particle size (P = 0.005) compared with non-Hispanic white women. The differences in HDL, HOMA-IR, VLDL and LDL size did not persist after adjustment for WHR while differences in LDL particle number (P = 0.04) and HDL size (P = 0.01) persisted.

LIMITATIONS, REASON FOR CAUTION

The sample size for the three groups was small but the findings were still significant. The women were mostly obese so the ethnic differences in metabolic disorders may not apply to non-obese women with PCOS.

WIDER IMPLICATIONS OF THE FINDINGS

Independent of BMI, obese, reproductive age, Hispanic women with PCOS in the USA had a greater degree of abdominal obesity, insulin resistance and dyslipidemia. Hispanic women with PCOS may benefit from more focused management of metabolic parameters.

STUDY FUNDING/COMPETING INTERESTS

This project was supported by the following National Institutes of Health grants: K23 DK080988-01A1 to S.S. and UL1RR029879 to CTSA at University of Illinois. None of the authors report any conflict of interests.

Authors+Show Affiliations

Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA ssam@medicine.bsd.uchicago.edu.Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois, Chicago, IL, USA.Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago, IL, USA.Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA Department of Medicine, Northshore University Health System, Chicago, IL, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25857311

Citation

Sam, Susan, et al. "Metabolic Dysfunction in Obese Hispanic Women With Polycystic Ovary Syndrome." Human Reproduction (Oxford, England), vol. 30, no. 6, 2015, pp. 1358-64.
Sam S, Scoccia B, Yalamanchi S, et al. Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome. Hum Reprod. 2015;30(6):1358-64.
Sam, S., Scoccia, B., Yalamanchi, S., & Mazzone, T. (2015). Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome. Human Reproduction (Oxford, England), 30(6), 1358-64. https://doi.org/10.1093/humrep/dev073
Sam S, et al. Metabolic Dysfunction in Obese Hispanic Women With Polycystic Ovary Syndrome. Hum Reprod. 2015;30(6):1358-64. PubMed PMID: 25857311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome. AU - Sam,Susan, AU - Scoccia,Bert, AU - Yalamanchi,Sudha, AU - Mazzone,Theodore, Y1 - 2015/04/08/ PY - 2014/12/03/received PY - 2015/03/16/accepted PY - 2015/4/11/entrez PY - 2015/4/11/pubmed PY - 2016/2/26/medline KW - dyslipidemia KW - high-density lipoprotein particle size KW - low-density lipoprotein particle number KW - nuclear magnetic resonance KW - waist-to-hip ratio SP - 1358 EP - 64 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 30 IS - 6 N2 - STUDY QUESTION: Are certain ethnic groups with polycystic ovary syndrome (PCOS) at increased risk of metabolic disorders? SUMMARY ANSWER: Obese Hispanic women with PCOS are at increased risk of metabolic disorders compared with age- and BMI-matched obese non-Hispanic white women with PCOS in the USA. WHAT IS KNOWN ALREADY: Ethnic differences in body composition and metabolic risk are well established. PCOS is a common disorder in women of reproductive age and is associated with high rates of insulin resistance, glucose intolerance and dyslipidemia. STUDY DESIGN, SIZE, DURATION: A cross-sectional observational study was performed at an Academic Medical Center on 60 women of reproductive age with PCOS. PARTICIPANTS/MATERIALS, SETTING, METHODS: Blood was obtained after fasting from 17 Hispanic, 22 non-Hispanic black and 21 non-Hispanic white women with PCOS who were similar in age and BMI. Anthropometric parameters, insulin, lipid and lipoprotein levels (measured by nuclear magnetic resonance) were compared between the three groups. MAIN RESULTS AND THE ROLE OF CHANCE: Age and BMI did not differ between the groups. Hispanic women with PCOS had higher waist-to-hip ratio (WHR) (P = 0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.03) and a more atherogenic lipid and lipoprotein profile consisting of lower high-density lipoprotein (HDL) (P = 0.02), higher low-density lipoprotein (LDL) particle number (P = 0.02), higher very low-density lipoprotein particle (VLDL) size (P = 0.03) and lower LDL (P = 0.03) and HDL particle size (P = 0.005) compared with non-Hispanic white women. The differences in HDL, HOMA-IR, VLDL and LDL size did not persist after adjustment for WHR while differences in LDL particle number (P = 0.04) and HDL size (P = 0.01) persisted. LIMITATIONS, REASON FOR CAUTION: The sample size for the three groups was small but the findings were still significant. The women were mostly obese so the ethnic differences in metabolic disorders may not apply to non-obese women with PCOS. WIDER IMPLICATIONS OF THE FINDINGS: Independent of BMI, obese, reproductive age, Hispanic women with PCOS in the USA had a greater degree of abdominal obesity, insulin resistance and dyslipidemia. Hispanic women with PCOS may benefit from more focused management of metabolic parameters. STUDY FUNDING/COMPETING INTERESTS: This project was supported by the following National Institutes of Health grants: K23 DK080988-01A1 to S.S. and UL1RR029879 to CTSA at University of Illinois. None of the authors report any conflict of interests. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/25857311/Metabolic_dysfunction_in_obese_Hispanic_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dev073 DB - PRIME DP - Unbound Medicine ER -