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Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years.

Abstract

OBJECTIVE

High soft drink consumption has been linked with asthma. Anecdotal evidence links high-fructose corn syrup with asthma. The receptor of advanced glycation end products (RAGE) has emerged as a mediator of asthma. The objectives of the present study were to: (i) assess the correlation between intake of beverages containing excess free fructose (EFF beverages) and asthma in children; and (ii) epidemiologically test the mechanistic hypothesis that intake of high EFF beverages, such as apple juice or beverages sweetened with high-fructose corn syrup, is associated with increased risk of asthma. This hypothesis is based on the possible effect of increases in the in situ intestinal formation of advanced glycation end products (enFruAGE) with EFF, which may be absorbed and play a role in RAGE-mediated asthma.

DESIGN

We examined cross-sectional associations between beverage intake and self-reported current or history of asthma. Exposure variables were EFF beverages, including apple juice (AJ), non-diet soft drinks (ndSD) and fruit drinks (FD). Orange juice (OJ), not an EFF beverage, was included as a comparison. Rao-Scott χ(2) analysis was used for prevalence differences and logistic regression for associations, adjusted for age, sex, race/ethnicity, BMI and total energy intake.

SETTING

Data are from the National Health and Nutrition Examination Survey 2003-2006, a nationally representative survey.

SUBJECTS

US children (n 1961) aged 2-9 years with complete responses on the dietary frequency questionnaire.

RESULTS

Intakes of EFF beverages were significantly associated with asthma in 2-9-year-olds. Adjusted odds of asthma in children consuming EFF beverages ≥5 times/week was more than five times that in children consuming these beverages ≤1 time/month (OR=5·29, P=0·012). Children consuming AJ ≥5 times/week v. ≤1 time/month, adjusted for the other beverages, were more than twice as likely to have asthma (OR=2·43, P=0·035). In contrast, there was a tendency for OJ to be protective.

CONCLUSIONS

These results support the hypothesis that intake of high EFF beverages, including AJ and beverages sweetened with high-fructose corn syrup, is associated with asthma in children aged 2-9 years. Results support the mechanistic hypothesis that enFruAGE may be an overlooked contributor to asthma in children. Longitudinal studies are needed to provide evidence of causal association.

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  • Authors+Show Affiliations

    ,

    1Biochemistry,Molecular Biology,NY Medical College,Valhalla,NY,USA.

    ,

    2Department of Medicine,The Icahn School of Medicine,New York,NY,USA.

    3Department of Clinical Laboratory and Nutritional Sciences,University of Massachusetts,Lowell,MA,USA.

    Source

    Public health nutrition 19:1 2016 Jan pg 123-30

    MeSH

    Asthma
    Body Mass Index
    Carbonated Beverages
    Child
    Child, Preschool
    Cross-Sectional Studies
    Energy Intake
    Female
    Fruit and Vegetable Juices
    Glycation End Products, Advanced
    High Fructose Corn Syrup
    Humans
    Logistic Models
    Male
    Malus
    Nutrition Surveys
    Prevalence
    Socioeconomic Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25857343

    Citation

    DeChristopher, Luanne Robalo, et al. "Intakes of Apple Juice, Fruit Drinks and Soda Are Associated With Prevalent Asthma in US Children Aged 2-9 Years." Public Health Nutrition, vol. 19, no. 1, 2016, pp. 123-30.
    DeChristopher LR, Uribarri J, Tucker KL. Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years. Public Health Nutr. 2016;19(1):123-30.
    DeChristopher, L. R., Uribarri, J., & Tucker, K. L. (2016). Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years. Public Health Nutrition, 19(1), pp. 123-30. doi:10.1017/S1368980015000865.
    DeChristopher LR, Uribarri J, Tucker KL. Intakes of Apple Juice, Fruit Drinks and Soda Are Associated With Prevalent Asthma in US Children Aged 2-9 Years. Public Health Nutr. 2016;19(1):123-30. PubMed PMID: 25857343.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years. AU - DeChristopher,Luanne Robalo, AU - Uribarri,Jaime, AU - Tucker,Katherine L, Y1 - 2015/04/10/ PY - 2015/4/11/entrez PY - 2015/4/11/pubmed PY - 2016/10/21/medline KW - Advanced glycation end products (AGE) KW - Asthma KW - Excess free fructose KW - Fructose epidemiology KW - Fructose malabsorption KW - Fructositis KW - Receptor of advanced glycation end products (RAGE) KW - enFruAGE SP - 123 EP - 30 JF - Public health nutrition JO - Public Health Nutr VL - 19 IS - 1 N2 - OBJECTIVE: High soft drink consumption has been linked with asthma. Anecdotal evidence links high-fructose corn syrup with asthma. The receptor of advanced glycation end products (RAGE) has emerged as a mediator of asthma. The objectives of the present study were to: (i) assess the correlation between intake of beverages containing excess free fructose (EFF beverages) and asthma in children; and (ii) epidemiologically test the mechanistic hypothesis that intake of high EFF beverages, such as apple juice or beverages sweetened with high-fructose corn syrup, is associated with increased risk of asthma. This hypothesis is based on the possible effect of increases in the in situ intestinal formation of advanced glycation end products (enFruAGE) with EFF, which may be absorbed and play a role in RAGE-mediated asthma. DESIGN: We examined cross-sectional associations between beverage intake and self-reported current or history of asthma. Exposure variables were EFF beverages, including apple juice (AJ), non-diet soft drinks (ndSD) and fruit drinks (FD). Orange juice (OJ), not an EFF beverage, was included as a comparison. Rao-Scott χ(2) analysis was used for prevalence differences and logistic regression for associations, adjusted for age, sex, race/ethnicity, BMI and total energy intake. SETTING: Data are from the National Health and Nutrition Examination Survey 2003-2006, a nationally representative survey. SUBJECTS: US children (n 1961) aged 2-9 years with complete responses on the dietary frequency questionnaire. RESULTS: Intakes of EFF beverages were significantly associated with asthma in 2-9-year-olds. Adjusted odds of asthma in children consuming EFF beverages ≥5 times/week was more than five times that in children consuming these beverages ≤1 time/month (OR=5·29, P=0·012). Children consuming AJ ≥5 times/week v. ≤1 time/month, adjusted for the other beverages, were more than twice as likely to have asthma (OR=2·43, P=0·035). In contrast, there was a tendency for OJ to be protective. CONCLUSIONS: These results support the hypothesis that intake of high EFF beverages, including AJ and beverages sweetened with high-fructose corn syrup, is associated with asthma in children aged 2-9 years. Results support the mechanistic hypothesis that enFruAGE may be an overlooked contributor to asthma in children. Longitudinal studies are needed to provide evidence of causal association. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/25857343/full_citation L2 - https://www.cambridge.org/core/product/identifier/S1368980015000865/type/journal_article DB - PRIME DP - Unbound Medicine ER -