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Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up.
J Clin Periodontol. 2015 May; 42(5):431-9.JC

Abstract

AIM

This study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) and serum levels of adipokines in patients with chronic periodontitis (CP) with or without obesity.

METHODS

Twenty patients with obesity and 20 patients without obesity, all with CP, received SRP. Serum and GCF levels of resistin, adiponectin, leptin, tumour necrosis factor [TNF]-α and interleukin [IL]-6 were evaluated by enzyme-linked immunosorbent assay at baseline, 3, 6 and 12 months post-therapy.

RESULTS

SRP reduced the amounts of TNF-α in deep sites and increased the concentration of adiponectin in shallow sites of non-obese patients (p < 0.05). SRP increased the concentrations of TNF-α and leptin in patients with obesity (p < 0.05). GCF levels of TNF-α were higher in patients with obesity than in patients without obesity at all time-points (p < 0.05). There were no changes in serum levels of any adipokines for any group after therapy (p > 0.05). Patients with obesity exhibited higher serum levels of leptin at all time-points and IL-6 at 3 months post-therapy (p < 0.05).

CONCLUSIONS

Obesity may modulate systemic and periodontal levels of adipokines in favour of pro-inflammation, independently of periodontal therapy. SRP did not affect the circulating levels of adipokines in patients with or without obesity.

Authors+Show Affiliations

Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil. Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.Biostatistics Unit, Public Health Department, University of Barcelona, Barcelona, Spain.Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25858047

Citation

Gonçalves, Tiago Eduardo Dias, et al. "Local and Serum Levels of Adipokines in Patients With Obesity After Periodontal Therapy: One-year Follow-up." Journal of Clinical Periodontology, vol. 42, no. 5, 2015, pp. 431-9.
Gonçalves TE, Zimmermann GS, Figueiredo LC, et al. Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. J Clin Periodontol. 2015;42(5):431-9.
Gonçalves, T. E., Zimmermann, G. S., Figueiredo, L. C., Souza, M. d. e. . C., da Cruz, D. F., Bastos, M. F., da Silva, H. D., & Duarte, P. M. (2015). Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. Journal of Clinical Periodontology, 42(5), 431-9. https://doi.org/10.1111/jcpe.12396
Gonçalves TE, et al. Local and Serum Levels of Adipokines in Patients With Obesity After Periodontal Therapy: One-year Follow-up. J Clin Periodontol. 2015;42(5):431-9. PubMed PMID: 25858047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. AU - Gonçalves,Tiago Eduardo Dias, AU - Zimmermann,Glaucia Santos, AU - Figueiredo,Luciene Cristina, AU - Souza,Monique de Carvalho, AU - da Cruz,Daniele Ferreira, AU - Bastos,Marta Ferreira, AU - da Silva,Hélio Doyle Pereira, AU - Duarte,Poliana Mendes, Y1 - 2015/04/30/ PY - 2015/03/29/accepted PY - 2015/4/11/entrez PY - 2015/4/11/pubmed PY - 2016/11/15/medline KW - IL-6 KW - TNF-α KW - adipokines KW - adiponectin KW - chronic periodontitis KW - leptin KW - obesity KW - resistin KW - root planing SP - 431 EP - 9 JF - Journal of clinical periodontology JO - J. Clin. Periodontol. VL - 42 IS - 5 N2 - AIM: This study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) and serum levels of adipokines in patients with chronic periodontitis (CP) with or without obesity. METHODS: Twenty patients with obesity and 20 patients without obesity, all with CP, received SRP. Serum and GCF levels of resistin, adiponectin, leptin, tumour necrosis factor [TNF]-α and interleukin [IL]-6 were evaluated by enzyme-linked immunosorbent assay at baseline, 3, 6 and 12 months post-therapy. RESULTS: SRP reduced the amounts of TNF-α in deep sites and increased the concentration of adiponectin in shallow sites of non-obese patients (p < 0.05). SRP increased the concentrations of TNF-α and leptin in patients with obesity (p < 0.05). GCF levels of TNF-α were higher in patients with obesity than in patients without obesity at all time-points (p < 0.05). There were no changes in serum levels of any adipokines for any group after therapy (p > 0.05). Patients with obesity exhibited higher serum levels of leptin at all time-points and IL-6 at 3 months post-therapy (p < 0.05). CONCLUSIONS: Obesity may modulate systemic and periodontal levels of adipokines in favour of pro-inflammation, independently of periodontal therapy. SRP did not affect the circulating levels of adipokines in patients with or without obesity. SN - 1600-051X UR - https://www.unboundmedicine.com/medline/citation/25858047/Local_and_serum_levels_of_adipokines_in_patients_with_obesity_after_periodontal_therapy:_one_year_follow_up_ L2 - https://doi.org/10.1111/jcpe.12396 DB - PRIME DP - Unbound Medicine ER -