Tags

Type your tag names separated by a space and hit enter

Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas.
Med Sci Monit. 2015 Apr 10; 21:1043-50.MS

Abstract

BACKGROUND

MALT lymphomas were classified for differential diagnostics of IgG4-dependent disease due to their exceptional predilection to intraorbital localization. Therefore, the goal of our studies was large retrospective analysis of patients diagnosed with MALT lymphomas within the orbital tissues, since no such studies have been conducted in Poland.

MATERIAL/METHODS

The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow. The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios.

RESULTS

Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. Detailed analysis and diagnostic screening for IgG4-related disease was performed and results meeting the criteria of IgG4-dependent disease were obtained in 10 out of 19 patients with the diagnosis of MALT tumor established on the basis of immunohistochemical assays.

CONCLUSIONS

MALT lymphomas are the most common of all lymphomas occurring within orbital tissues. In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma.

Authors+Show Affiliations

Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.Department of Pathomorphology, Medical College Jagiellonian University, Cracow, Poland.Department of Pathomorphology, Medical College Jagiellonian University, Cracow, Poland.Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.Department of Cardiac and Vascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Cracow, Poland.Department of Pain Pharmacology, Institute of Pharmacology, Cracow, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25858500

Citation

Oleś, Krzysztof, et al. "Immunoglobulin G4-related Disease (IgG4-RD) in the Orbit: Mucosa-associated Lymphoid Tissue (MALT)-type Lymphomas." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 21, 2015, pp. 1043-50.
Oleś K, Składzień J, Szczepański W, et al. Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas. Med Sci Monit. 2015;21:1043-50.
Oleś, K., Składzień, J., Szczepański, W., Okoń, K., Leszczyńska, J., Bojanowska, E., Bartuś, K., & Mika, J. (2015). Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 1043-50. https://doi.org/10.12659/MSM.893043
Oleś K, et al. Immunoglobulin G4-related Disease (IgG4-RD) in the Orbit: Mucosa-associated Lymphoid Tissue (MALT)-type Lymphomas. Med Sci Monit. 2015 Apr 10;21:1043-50. PubMed PMID: 25858500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas. AU - Oleś,Krzysztof, AU - Składzień,Jacek, AU - Szczepański,Wojciech, AU - Okoń,Krzysztof, AU - Leszczyńska,Joanna, AU - Bojanowska,Emilia, AU - Bartuś,Krzysztof, AU - Mika,Joanna, Y1 - 2015/04/10/ PY - 2015/4/11/entrez PY - 2015/4/11/pubmed PY - 2016/4/23/medline SP - 1043 EP - 50 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 21 N2 - BACKGROUND: MALT lymphomas were classified for differential diagnostics of IgG4-dependent disease due to their exceptional predilection to intraorbital localization. Therefore, the goal of our studies was large retrospective analysis of patients diagnosed with MALT lymphomas within the orbital tissues, since no such studies have been conducted in Poland. MATERIAL/METHODS: The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow. The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios. RESULTS: Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. Detailed analysis and diagnostic screening for IgG4-related disease was performed and results meeting the criteria of IgG4-dependent disease were obtained in 10 out of 19 patients with the diagnosis of MALT tumor established on the basis of immunohistochemical assays. CONCLUSIONS: MALT lymphomas are the most common of all lymphomas occurring within orbital tissues. In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/25858500/Immunoglobulin_G4_related_disease__IgG4_RD__in_the_orbit:_mucosa_associated_lymphoid_tissue__MALT__type_lymphomas_ L2 - https://www.medscimonit.com/download/index/idArt/893043 DB - PRIME DP - Unbound Medicine ER -