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Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.
Allergy. 2015 Jul; 70(7):820-7.A

Abstract

BACKGROUND

Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma.

OBJECTIVE

To describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts.

METHODS

We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.

RESULTS

House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1 = 3.3 μg/g) and LISAplus (GM Der f1 = 2.1 μg/g) and lowest in BAMSE (GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly (P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes.

CONCLUSION

Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.

Authors+Show Affiliations

Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain.Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. Sach's Children's Hospital, Stockholm, Sweden. Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.Department of Environmental Immunology, FZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. Sach's Children's Hospital, Stockholm, Sweden. Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.Klinik für Pädiatrie m. S. Pneumologie und Immunologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain.Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany. Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany. Institute of Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany.Area de Salud de Menorca, IB-SALUT, Menorca, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25858551

Citation

Casas, L, et al. "Early-life House Dust Mite Allergens, Childhood Mite Sensitization, and Respiratory Outcomes." Allergy, vol. 70, no. 7, 2015, pp. 820-7.
Casas L, Sunyer J, Tischer C, et al. Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. Allergy. 2015;70(7):820-7.
Casas, L., Sunyer, J., Tischer, C., Gehring, U., Wickman, M., Garcia-Esteban, R., Lehmann, I., Kull, I., Reich, A., Lau, S., Wijga, A., Antó, J. M., Nawrot, T. S., Heinrich, J., Keil, T., & Torrent, M. (2015). Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. Allergy, 70(7), 820-7. https://doi.org/10.1111/all.12626
Casas L, et al. Early-life House Dust Mite Allergens, Childhood Mite Sensitization, and Respiratory Outcomes. Allergy. 2015;70(7):820-7. PubMed PMID: 25858551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. AU - Casas,L, AU - Sunyer,J, AU - Tischer,C, AU - Gehring,U, AU - Wickman,M, AU - Garcia-Esteban,R, AU - Lehmann,I, AU - Kull,I, AU - Reich,A, AU - Lau,S, AU - Wijga,A, AU - Antó,J M, AU - Nawrot,T S, AU - Heinrich,J, AU - Keil,T, AU - Torrent,M, Y1 - 2015/04/20/ PY - 2015/04/01/accepted PY - 2015/4/11/entrez PY - 2015/4/11/pubmed PY - 2016/3/25/medline KW - allergens and epitopes KW - epidemiology KW - pediatrics SP - 820 EP - 7 JF - Allergy JO - Allergy VL - 70 IS - 7 N2 - BACKGROUND: Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. OBJECTIVE: To describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts. METHODS: We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals. RESULTS: House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1 = 3.3 μg/g) and LISAplus (GM Der f1 = 2.1 μg/g) and lowest in BAMSE (GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly (P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes. CONCLUSION: Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/25858551/Early_life_house_dust_mite_allergens_childhood_mite_sensitization_and_respiratory_outcomes_ L2 - https://doi.org/10.1111/all.12626 DB - PRIME DP - Unbound Medicine ER -