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Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia.
J Intensive Care Med. 2016 Jun; 31(5):344-8.JI

Abstract

BACKGROUND

An increasing number of patients are being infected with Middle East respiratory syndrome coronavirus (MERS-CoV) since the first case was identified in September 2012. We report the characteristics and outcomes of MERS-CoV-confirmed patients who developed critical illness requiring admission to an intensive care unit (ICU).

METHODS

We conducted a prospective cohort study of all MERS-CoV-confirmed cases who were admitted to our ICU from March 20, 2014, till June 1, 2014. Presenting symptoms, comorbid conditions, and details of their ICU stay were recorded.

RESULTS

Eight patients were admitted to the ICU with MERS-CoV infection. All had signs of respiratory distress with 7 requiring mechanical ventilation. Three patients were health care workers. In all, 6 patients had comorbid conditions and 5 patients developed multiorgan system failure (MOSF). In all, 5 patients expired, 2 were discharged alive, and 1 remained intubated at the end of the study period.

CONCLUSIONS

Middle East respiratory syndrome coronavirus carries a high mortality rate in patients who require ICU admission, with a significant number of patients developing MOSF. Further investigation is needed to determine optimal management guidelines for these patients.

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Authors+Show Affiliations

Al-Hameed F
Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia These authors contributed equally to the work and are co-authors.
Wahla AS
Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia These authors contributed equally to the work and are co-authors. aliwahla@hotmail.com.
Siddiqui S
Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia.
Ghabashi A
Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia.
Al-Shomrani M
King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia Department of Infection Prevention and Control, King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
Al-Thaqafi A
King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia Department of Infection Prevention and Control, King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
Tashkandi Y
Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia.

MeSH

AdultAgedAged, 80 and overCommunicable Diseases, EmergingCoronavirus InfectionsCross InfectionFemaleHospitalizationHumansIntensive Care UnitsMaleMiddle AgedMiddle East Respiratory Syndrome CoronavirusProspective StudiesRespiration, ArtificialSaudi ArabiaTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25862629

Citation

Al-Hameed, Fahad, et al. "Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia." Journal of Intensive Care Medicine, vol. 31, no. 5, 2016, pp. 344-8.
Al-Hameed F, Wahla AS, Siddiqui S, et al. Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia. J Intensive Care Med. 2016;31(5):344-8.
Al-Hameed, F., Wahla, A. S., Siddiqui, S., Ghabashi, A., Al-Shomrani, M., Al-Thaqafi, A., & Tashkandi, Y. (2016). Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia. Journal of Intensive Care Medicine, 31(5), 344-8. https://doi.org/10.1177/0885066615579858
Al-Hameed F, et al. Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia. J Intensive Care Med. 2016;31(5):344-8. PubMed PMID: 25862629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia. AU - Al-Hameed,Fahad, AU - Wahla,Ali S, AU - Siddiqui,Shakeel, AU - Ghabashi,Alaa, AU - Al-Shomrani,Majid, AU - Al-Thaqafi,Abdulhakeem, AU - Tashkandi,Yasir, Y1 - 2015/04/09/ PY - 2014/11/04/received PY - 2015/02/10/accepted PY - 2015/4/12/entrez PY - 2015/4/12/pubmed PY - 2017/8/16/medline KW - Middle East respiratory syndrome coronavirus KW - intensive care KW - respiratory failure SP - 344 EP - 8 JF - Journal of intensive care medicine JO - J Intensive Care Med VL - 31 IS - 5 N2 - BACKGROUND: An increasing number of patients are being infected with Middle East respiratory syndrome coronavirus (MERS-CoV) since the first case was identified in September 2012. We report the characteristics and outcomes of MERS-CoV-confirmed patients who developed critical illness requiring admission to an intensive care unit (ICU). METHODS: We conducted a prospective cohort study of all MERS-CoV-confirmed cases who were admitted to our ICU from March 20, 2014, till June 1, 2014. Presenting symptoms, comorbid conditions, and details of their ICU stay were recorded. RESULTS: Eight patients were admitted to the ICU with MERS-CoV infection. All had signs of respiratory distress with 7 requiring mechanical ventilation. Three patients were health care workers. In all, 6 patients had comorbid conditions and 5 patients developed multiorgan system failure (MOSF). In all, 5 patients expired, 2 were discharged alive, and 1 remained intubated at the end of the study period. CONCLUSIONS: Middle East respiratory syndrome coronavirus carries a high mortality rate in patients who require ICU admission, with a significant number of patients developing MOSF. Further investigation is needed to determine optimal management guidelines for these patients. SN - 1525-1489 UR - https://www.unboundmedicine.com/medline/citation/25862629/Characteristics_and_Outcomes_of_Middle_East_Respiratory_Syndrome_Coronavirus_Patients_Admitted_to_an_Intensive_Care_Unit_in_Jeddah_Saudi_Arabia_ L2 - https://journals.sagepub.com/doi/10.1177/0885066615579858?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -