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Analysis of 24 Y chromosomal STR haplotypes in a Chinese Han population sample from Henan Province, Central China.
Forensic Sci Int Genet. 2015 Jul; 17:83-86.FS

Abstract

We analyzed haplotypes for 24 Y chromosomal STRs (Y-STRs), including 17 Yfiler loci (DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DY438, DYS439, DYS448, DYS456, DYS458, DYS635 and Y-GATA-H4) and 7 additional STRs (DYS388, DYS444, DYS447, DYS449, DYS522 and DYS527a/b) in 1100 unrelated Chinese Han individuals from Henan Province using AGCU Y24 STR kit systems. The calculated average gene diversity (GD) values ranged from 0.4105 to 0.9647 for the DYS388 and DYS385a/b loci, respectively. The discriminatory capacity (DC) was 72.91% with 802 observed haplotypes using 17 Yfiler loci, by the addition of 7 Y-STRs to the Yfiler system, the DC was increased to 79.09% while showing 870 observed haplotypes. Among the additional 7 Y-STRs, DYS449, DYS527a/b, DYS444 and DYS522 were major contributors to enhancing discrimination. In the analysis of molecular variance, the Henan Han population clustered with Han origin populations and showed significant differences from other Non-Han populations. In the present study, we report 24 Y-STR population data in Henan Han population, and we emphasize the need for adding additional markers to the commonly used 17 Yfiler loci to achieve more improved discriminatory capacity in a population with low genetic diversity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shi M
Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, PR China; Collaborative Innovation Center of Judicial Civilization, PR China; Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing 100088, PR China.
Liu Y
Xuchang Institute of Forensic Sciences, Public Security Bureau of Henan Province, Xuchang 461000, PR China.
Zhang J
Xuchang Institute of Forensic Sciences, Public Security Bureau of Henan Province, Xuchang 461000, PR China.
Bai R
Collaborative Innovation Center of Judicial Civilization, PR China; Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing 100088, PR China.
Lv X
Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing 100088, PR China.
Ma S
Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, PR China. Electronic address: mashuhua6699@yahoo.com.

MeSH

Asian PeopleChinaChromosomes, Human, YDNAEthnicityForensic GeneticsGenetics, PopulationHaplotypesHumansMaleMicrosatellite Repeats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25864156

Citation

Shi, Meisen, et al. "Analysis of 24 Y Chromosomal STR Haplotypes in a Chinese Han Population Sample From Henan Province, Central China." Forensic Science International. Genetics, vol. 17, 2015, pp. 83-86.
Shi M, Liu Y, Zhang J, et al. Analysis of 24 Y chromosomal STR haplotypes in a Chinese Han population sample from Henan Province, Central China. Forensic Sci Int Genet. 2015;17:83-86.
Shi, M., Liu, Y., Zhang, J., Bai, R., Lv, X., & Ma, S. (2015). Analysis of 24 Y chromosomal STR haplotypes in a Chinese Han population sample from Henan Province, Central China. Forensic Science International. Genetics, 17, 83-86. https://doi.org/10.1016/j.fsigen.2015.04.001
Shi M, et al. Analysis of 24 Y Chromosomal STR Haplotypes in a Chinese Han Population Sample From Henan Province, Central China. Forensic Sci Int Genet. 2015;17:83-86. PubMed PMID: 25864156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of 24 Y chromosomal STR haplotypes in a Chinese Han population sample from Henan Province, Central China. AU - Shi,Meisen, AU - Liu,Yaju, AU - Zhang,Juntao, AU - Bai,Rufeng, AU - Lv,Xiaojiao, AU - Ma,Shuhua, Y1 - 2015/04/04/ PY - 2014/12/31/received PY - 2015/03/29/revised PY - 2015/04/03/accepted PY - 2015/4/13/entrez PY - 2015/4/13/pubmed PY - 2016/4/19/medline KW - Central China KW - Haplotypes KW - Henan Han KW - Multidimensional scaling KW - Y-STR KW - Yfiler SP - 83 EP - 86 JF - Forensic science international. Genetics JO - Forensic Sci Int Genet VL - 17 N2 - We analyzed haplotypes for 24 Y chromosomal STRs (Y-STRs), including 17 Yfiler loci (DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DY438, DYS439, DYS448, DYS456, DYS458, DYS635 and Y-GATA-H4) and 7 additional STRs (DYS388, DYS444, DYS447, DYS449, DYS522 and DYS527a/b) in 1100 unrelated Chinese Han individuals from Henan Province using AGCU Y24 STR kit systems. The calculated average gene diversity (GD) values ranged from 0.4105 to 0.9647 for the DYS388 and DYS385a/b loci, respectively. The discriminatory capacity (DC) was 72.91% with 802 observed haplotypes using 17 Yfiler loci, by the addition of 7 Y-STRs to the Yfiler system, the DC was increased to 79.09% while showing 870 observed haplotypes. Among the additional 7 Y-STRs, DYS449, DYS527a/b, DYS444 and DYS522 were major contributors to enhancing discrimination. In the analysis of molecular variance, the Henan Han population clustered with Han origin populations and showed significant differences from other Non-Han populations. In the present study, we report 24 Y-STR population data in Henan Han population, and we emphasize the need for adding additional markers to the commonly used 17 Yfiler loci to achieve more improved discriminatory capacity in a population with low genetic diversity. SN - 1878-0326 UR - https://www.unboundmedicine.com/medline/citation/25864156/Analysis_of_24_Y_chromosomal_STR_haplotypes_in_a_Chinese_Han_population_sample_from_Henan_Province_Central_China_ DB - PRIME DP - Unbound Medicine ER -