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Hydrogen sulfide and polysulfides as signaling molecules.
Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(4):131-59.PJ

Abstract

Hydrogen sulfide (H2S) is a familiar toxic gas that smells of rotten eggs. After the identification of endogenous H2S in the mammalian brain two decades ago, studies of this molecule uncovered physiological roles in processes such as neuromodulation, vascular tone regulation, cytoprotection against oxidative stress, angiogenesis, anti-inflammation, and oxygen sensing. Enzymes that produce H2S, such as cystathionine β-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate sulfurtransferase have been studied intensively and well characterized. Polysulfides, which have a higher number of inner sulfur atoms than that in H2S, were recently identified as potential signaling molecules that can activate ion channels, transcription factors, and tumor suppressors with greater potency than that of H2S. This article focuses on our contribution to the discovery of these molecules and their metabolic pathways and mechanisms of action.

Authors+Show Affiliations

Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25864468

Citation

Kimura, Hideo. "Hydrogen Sulfide and Polysulfides as Signaling Molecules." Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, vol. 91, no. 4, 2015, pp. 131-59.
Kimura H. Hydrogen sulfide and polysulfides as signaling molecules. Proc Jpn Acad Ser B Phys Biol Sci. 2015;91(4):131-59.
Kimura, H. (2015). Hydrogen sulfide and polysulfides as signaling molecules. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 91(4), 131-59. https://doi.org/10.2183/pjab.91.131
Kimura H. Hydrogen Sulfide and Polysulfides as Signaling Molecules. Proc Jpn Acad Ser B Phys Biol Sci. 2015;91(4):131-59. PubMed PMID: 25864468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide and polysulfides as signaling molecules. A1 - Kimura,Hideo, PY - 2015/4/14/entrez PY - 2015/4/14/pubmed PY - 2015/12/30/medline SP - 131 EP - 59 JF - Proceedings of the Japan Academy. Series B, Physical and biological sciences JO - Proc Jpn Acad Ser B Phys Biol Sci VL - 91 IS - 4 N2 - Hydrogen sulfide (H2S) is a familiar toxic gas that smells of rotten eggs. After the identification of endogenous H2S in the mammalian brain two decades ago, studies of this molecule uncovered physiological roles in processes such as neuromodulation, vascular tone regulation, cytoprotection against oxidative stress, angiogenesis, anti-inflammation, and oxygen sensing. Enzymes that produce H2S, such as cystathionine β-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate sulfurtransferase have been studied intensively and well characterized. Polysulfides, which have a higher number of inner sulfur atoms than that in H2S, were recently identified as potential signaling molecules that can activate ion channels, transcription factors, and tumor suppressors with greater potency than that of H2S. This article focuses on our contribution to the discovery of these molecules and their metabolic pathways and mechanisms of action. SN - 1349-2896 UR - https://www.unboundmedicine.com/medline/citation/25864468/Hydrogen_sulfide_and_polysulfides_as_signaling_molecules_ L2 - https://dx.doi.org/10.2183/pjab.91.131 DB - PRIME DP - Unbound Medicine ER -