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Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries.
J Steroid Biochem Mol Biol. 2016 Jan; 155(Pt B):257-63.JS

Abstract

BACKGROUND

Controversy exists regarding whether vitamin D deficiency could influence the etiology of pancreatic cancer. Several cohort studies have found that high serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with low risk of pancreatic cancer, while others have not.

HYPOTHESIS

Low ultraviolet B irradiance is associated with high incidence of pancreatic cancer.

METHODS

Age-standardized pancreatic cancer incidence rates were obtained from GLOBOCAN in 2008. The association between cloud-adjusted UVB irradiance and age-standardized incidence rates of pancreatic cancer was analyzed using regression.

RESULTS

Overall, the lower the cloud-adjusted UVB irradiance, the higher the incidence rate of pancreatic cancer. Residents of countries with low UVB irradiance had approximately 6 times the incidence rates as those in countries with high UVB irradiance (p<0.0001 for males and p<0.0001 for females). This association persisted after adjustment for traditional risk factors of pancreatic cancer (p=0.0182 for males and p=0.0029 for females).

CONCLUSIONS

There was an inverse association of cloud-adjusted UVB irradiance with incidence of pancreatic cancer that persisted after adjustment. This result is consistent with an inverse association of overall vitamin D deficiency in countries with lower UVB irradiance with risk of pancreatic cancer. Further research on the role of 25(OH)D in reduction of pancreatic cancer in individuals would be desirable to expand the limited avenues available for prevention of this highly fatal disease. This article is part of a Special Issue entitled '17th Vitamin D Workshop'.

Authors+Show Affiliations

Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA.Division of Global Health, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA; Graduate School of Public Health, San Diego State University, San Diego, CA, USA. Electronic address: cuomo@rohan.sdsu.edu.Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA.Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA.Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25864626

Citation

Garland, Cedric F., et al. "Cloud Cover-adjusted Ultraviolet B Irradiance and Pancreatic Cancer Incidence in 172 Countries." The Journal of Steroid Biochemistry and Molecular Biology, vol. 155, no. Pt B, 2016, pp. 257-63.
Garland CF, Cuomo RE, Gorham ED, et al. Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries. J Steroid Biochem Mol Biol. 2016;155(Pt B):257-63.
Garland, C. F., Cuomo, R. E., Gorham, E. D., Zeng, K., & Mohr, S. B. (2016). Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries. The Journal of Steroid Biochemistry and Molecular Biology, 155(Pt B), 257-63. https://doi.org/10.1016/j.jsbmb.2015.04.004
Garland CF, et al. Cloud Cover-adjusted Ultraviolet B Irradiance and Pancreatic Cancer Incidence in 172 Countries. J Steroid Biochem Mol Biol. 2016;155(Pt B):257-63. PubMed PMID: 25864626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries. AU - Garland,Cedric F, AU - Cuomo,Raphael E, AU - Gorham,Edward D, AU - Zeng,Kenneth, AU - Mohr,Sharif B, Y1 - 2015/04/09/ PY - 2014/07/23/received PY - 2015/03/24/revised PY - 2015/04/04/accepted PY - 2015/4/14/entrez PY - 2015/4/14/pubmed PY - 2016/4/20/medline KW - Epidemiology KW - Incidence KW - International comparisons KW - Pancreatic cancer KW - UVB KW - Ultraviolet rays KW - Vitamin D SP - 257 EP - 63 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 155 IS - Pt B N2 - BACKGROUND: Controversy exists regarding whether vitamin D deficiency could influence the etiology of pancreatic cancer. Several cohort studies have found that high serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with low risk of pancreatic cancer, while others have not. HYPOTHESIS: Low ultraviolet B irradiance is associated with high incidence of pancreatic cancer. METHODS: Age-standardized pancreatic cancer incidence rates were obtained from GLOBOCAN in 2008. The association between cloud-adjusted UVB irradiance and age-standardized incidence rates of pancreatic cancer was analyzed using regression. RESULTS: Overall, the lower the cloud-adjusted UVB irradiance, the higher the incidence rate of pancreatic cancer. Residents of countries with low UVB irradiance had approximately 6 times the incidence rates as those in countries with high UVB irradiance (p<0.0001 for males and p<0.0001 for females). This association persisted after adjustment for traditional risk factors of pancreatic cancer (p=0.0182 for males and p=0.0029 for females). CONCLUSIONS: There was an inverse association of cloud-adjusted UVB irradiance with incidence of pancreatic cancer that persisted after adjustment. This result is consistent with an inverse association of overall vitamin D deficiency in countries with lower UVB irradiance with risk of pancreatic cancer. Further research on the role of 25(OH)D in reduction of pancreatic cancer in individuals would be desirable to expand the limited avenues available for prevention of this highly fatal disease. This article is part of a Special Issue entitled '17th Vitamin D Workshop'. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/25864626/Cloud_cover_adjusted_ultraviolet_B_irradiance_and_pancreatic_cancer_incidence_in_172_countries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(15)00101-6 DB - PRIME DP - Unbound Medicine ER -