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Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood.
Epidemiology 2015; 26(4):458-65E

Abstract

BACKGROUND

Vitamin D status during prenatal brain development may influence risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. However, there are no prospective studies addressing this hypothesis. We aimed to examine whether maternal vitamin D status in pregnancy is associated with risk of ADHD-like symptoms in offspring.

METHODS

We conducted a prospective study analyzing data from 1,650 mother-child pairs from five birth cohorts embedded in the INMA Project (Spain, 1997-2008). Maternal vitamin D status in pregnancy was estimated by measuring plasma concentration of 25-hydroxyvitamin D3 [25(OH)D3] at 13 weeks of gestation. Children were assessed by teachers for ADHD-like symptoms at ages 4-5 years using the Diagnostic and Statistical Manual of Mental Disorders ADHD form list.

RESULTS

After adjustment, the number of total ADHD-like symptoms in children decreased by 11% per 10 ng/ml increment of maternal 25(OH)D3 concentration (incidence rate ratio [IRR] = 0.89; 95% confidence interval [CI] = 0.80, 0.98). Similarly, the number of symptoms in the ADHD subscales decreased in relation to higher maternal 25(OH)D3 concentration (IRR per 10 ng/ml increment = 0.89; 95% CI = 0.79, 0.99 for the inattention scale; and IRR = 0.88; 95% CI = 0.78, 0.99 for the hyperactivity-impulsivity scale). Using diagnostic criteria, we found an association of increasing maternal 25(OH)D3 with a lower risk of ADHD DSM-IV (relative risk ratio per 10 ng/ml increment = 0.87; 95% CI = 0.72, 1.06) and ICD-10 hyperkinetic disorder (relative risk ratio = 0.72; 95% CI = 0.49, 1.04) in children.

CONCLUSION

Higher maternal circulating levels of 25(OH)D3 in pregnancy are associated with lower risk of developing ADHD-like symptoms in childhood.

Authors+Show Affiliations

From the aCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain; bVirgen de la Arrixaca Universtiy Hospital, IMIB-Arrixaca Research Institute, Murcia, Spain; cCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; dHospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain; eUniversitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; fIB-SALUT, Area de Salut de Menorca, Balearic Islands, Spain; gUniversity of Valencia, Valencia, Spain; hCenter for Public Health Research (CSISP-FISABIO), Valencia, Spain; iDepartment of Basic Psychological Processes and Their Development, Basque Country University UPV/EHU, San Sebastian, Spain; jBiodonostia Institute, San Sebastian, Gipuzkoa, Spain; kPublic Health Laboratory, Basque Government, Bilbao, Spain; lHospital San Agustín, Avilés, Asturias, Spain; and mUniversity of Oviedo, Asturias, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25867115

Citation

Morales, Eva, et al. "Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood." Epidemiology (Cambridge, Mass.), vol. 26, no. 4, 2015, pp. 458-65.
Morales E, Julvez J, Torrent M, et al. Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology. 2015;26(4):458-65.
Morales, E., Julvez, J., Torrent, M., Ballester, F., Rodríguez-Bernal, C. L., Andiarena, A., ... Sunyer, J. (2015). Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology (Cambridge, Mass.), 26(4), pp. 458-65. doi:10.1097/EDE.0000000000000292.
Morales E, et al. Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology. 2015;26(4):458-65. PubMed PMID: 25867115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. AU - Morales,Eva, AU - Julvez,Jordi, AU - Torrent,Maties, AU - Ballester,Ferran, AU - Rodríguez-Bernal,Clara L, AU - Andiarena,Ainara, AU - Vegas,Oscar, AU - Castilla,Ane Miren, AU - Rodriguez-Dehli,Cristina, AU - Tardón,Adonina, AU - Sunyer,Jordi, PY - 2015/4/14/entrez PY - 2015/4/14/pubmed PY - 2016/2/26/medline SP - 458 EP - 65 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 26 IS - 4 N2 - BACKGROUND: Vitamin D status during prenatal brain development may influence risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. However, there are no prospective studies addressing this hypothesis. We aimed to examine whether maternal vitamin D status in pregnancy is associated with risk of ADHD-like symptoms in offspring. METHODS: We conducted a prospective study analyzing data from 1,650 mother-child pairs from five birth cohorts embedded in the INMA Project (Spain, 1997-2008). Maternal vitamin D status in pregnancy was estimated by measuring plasma concentration of 25-hydroxyvitamin D3 [25(OH)D3] at 13 weeks of gestation. Children were assessed by teachers for ADHD-like symptoms at ages 4-5 years using the Diagnostic and Statistical Manual of Mental Disorders ADHD form list. RESULTS: After adjustment, the number of total ADHD-like symptoms in children decreased by 11% per 10 ng/ml increment of maternal 25(OH)D3 concentration (incidence rate ratio [IRR] = 0.89; 95% confidence interval [CI] = 0.80, 0.98). Similarly, the number of symptoms in the ADHD subscales decreased in relation to higher maternal 25(OH)D3 concentration (IRR per 10 ng/ml increment = 0.89; 95% CI = 0.79, 0.99 for the inattention scale; and IRR = 0.88; 95% CI = 0.78, 0.99 for the hyperactivity-impulsivity scale). Using diagnostic criteria, we found an association of increasing maternal 25(OH)D3 with a lower risk of ADHD DSM-IV (relative risk ratio per 10 ng/ml increment = 0.87; 95% CI = 0.72, 1.06) and ICD-10 hyperkinetic disorder (relative risk ratio = 0.72; 95% CI = 0.49, 1.04) in children. CONCLUSION: Higher maternal circulating levels of 25(OH)D3 in pregnancy are associated with lower risk of developing ADHD-like symptoms in childhood. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/25867115/Vitamin_D_in_Pregnancy_and_Attention_Deficit_Hyperactivity_Disorder_like_Symptoms_in_Childhood_ L2 - http://dx.doi.org/10.1097/EDE.0000000000000292 DB - PRIME DP - Unbound Medicine ER -