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Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications.
Mol Ther 2015; 23(5):812-823MT

Abstract

Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the current interest in therapeutic application of MSCs to various disease settings can be linked to their immunosuppressive and anti-inflammatory properties. One of the key mechanisms of MSC anti-inflammatory effects is the secretion of soluble factors with paracrine actions. Recently it has emerged that the paracrine functions of MSCs could, at least in part, be mediated by extracellular vesicles (EVs). EVs are predominantly released from the endosomal compartment and contain a cargo that includes miRNA, mRNA, and proteins from their cells of origin. Recent animal model-based studies suggest that EVs have significant potential as a novel alternative to whole cell therapies. Compared to their parent cells, EVs may have a superior safety profile and can be safely stored without losing function. In this article, we review current knowledge related to the potential use of MSC-derived EVs in various diseases and discuss the promising future for EVs as an alternative, cell-free therapy.

Authors+Show Affiliations

Regenerative Medicine Institute (REMEDI), College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland. Electronic address: sweta.rani@nuigalway.ie.Discipline of Pharmacology and Therapeutics, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.Regenerative Medicine Institute (REMEDI), College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.Regenerative Medicine Institute (REMEDI), College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25868399

Citation

Rani, Sweta, et al. "Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications." Molecular Therapy : the Journal of the American Society of Gene Therapy, vol. 23, no. 5, 2015, pp. 812-823.
Rani S, Ryan AE, Griffin MD, et al. Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Mol Ther. 2015;23(5):812-823.
Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015). Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Molecular Therapy : the Journal of the American Society of Gene Therapy, 23(5), pp. 812-823. doi:10.1038/mt.2015.44.
Rani S, et al. Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Mol Ther. 2015;23(5):812-823. PubMed PMID: 25868399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. AU - Rani,Sweta, AU - Ryan,Aideen E, AU - Griffin,Matthew D, AU - Ritter,Thomas, Y1 - 2015/03/19/ PY - 2014/12/08/received PY - 2015/02/20/accepted PY - 2015/4/15/entrez PY - 2015/4/15/pubmed PY - 2016/2/3/medline SP - 812 EP - 823 JF - Molecular therapy : the journal of the American Society of Gene Therapy JO - Mol. Ther. VL - 23 IS - 5 N2 - Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the current interest in therapeutic application of MSCs to various disease settings can be linked to their immunosuppressive and anti-inflammatory properties. One of the key mechanisms of MSC anti-inflammatory effects is the secretion of soluble factors with paracrine actions. Recently it has emerged that the paracrine functions of MSCs could, at least in part, be mediated by extracellular vesicles (EVs). EVs are predominantly released from the endosomal compartment and contain a cargo that includes miRNA, mRNA, and proteins from their cells of origin. Recent animal model-based studies suggest that EVs have significant potential as a novel alternative to whole cell therapies. Compared to their parent cells, EVs may have a superior safety profile and can be safely stored without losing function. In this article, we review current knowledge related to the potential use of MSC-derived EVs in various diseases and discuss the promising future for EVs as an alternative, cell-free therapy. SN - 1525-0024 UR - https://www.unboundmedicine.com/medline/citation/25868399/Mesenchymal_Stem_Cell_derived_Extracellular_Vesicles:_Toward_Cell_free_Therapeutic_Applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-0016(16)30106-X DB - PRIME DP - Unbound Medicine ER -