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Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions.
Pestic Biochem Physiol. 2015 Mar; 119:16-27.PB

Abstract

Deltamethrin (DLM) being a potent immunotoxicant affects both humoral and cell mediated immunity. Thus, for the amelioration of its effects, two different bioactive herbal extracts piperine and curcumin are evaluated and their efficacy has been compared. The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective. DLM induced apoptotic markers such as oxidative stress and caspase 3 have been attenuated more significantly by piperine as compared to curcumin. Phenotypic and cytokine changes have also been mitigated best with piperine. Thus, these findings strongly demonstrate that piperine displays the more anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM induced splenic apoptosis as compared to curcumin. So, piperine can be considered the drug of choice under immunocompromised conditions.

Authors+Show Affiliations

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India.Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India. Electronic address: nsharmabit@gmail.com.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25868812

Citation

Kumar, Anoop, and Neelima Sharma. "Comparative Efficacy of Piperine and Curcumin in Deltamethrin Induced Splenic Apoptosis and Altered Immune Functions." Pesticide Biochemistry and Physiology, vol. 119, 2015, pp. 16-27.
Kumar A, Sharma N. Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pestic Biochem Physiol. 2015;119:16-27.
Kumar, A., & Sharma, N. (2015). Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pesticide Biochemistry and Physiology, 119, 16-27. https://doi.org/10.1016/j.pestbp.2015.03.003
Kumar A, Sharma N. Comparative Efficacy of Piperine and Curcumin in Deltamethrin Induced Splenic Apoptosis and Altered Immune Functions. Pestic Biochem Physiol. 2015;119:16-27. PubMed PMID: 25868812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. AU - Kumar,Anoop, AU - Sharma,Neelima, Y1 - 2015/03/10/ PY - 2014/12/25/received PY - 2015/03/04/revised PY - 2015/03/05/accepted PY - 2015/4/15/entrez PY - 2015/4/15/pubmed PY - 2016/1/5/medline KW - Apoptosis KW - Curcumin KW - Deltamethrin KW - Oxidative stress KW - Phenotyping KW - Piperine SP - 16 EP - 27 JF - Pesticide biochemistry and physiology JO - Pestic Biochem Physiol VL - 119 N2 - Deltamethrin (DLM) being a potent immunotoxicant affects both humoral and cell mediated immunity. Thus, for the amelioration of its effects, two different bioactive herbal extracts piperine and curcumin are evaluated and their efficacy has been compared. The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective. DLM induced apoptotic markers such as oxidative stress and caspase 3 have been attenuated more significantly by piperine as compared to curcumin. Phenotypic and cytokine changes have also been mitigated best with piperine. Thus, these findings strongly demonstrate that piperine displays the more anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM induced splenic apoptosis as compared to curcumin. So, piperine can be considered the drug of choice under immunocompromised conditions. SN - 1095-9939 UR - https://www.unboundmedicine.com/medline/citation/25868812/Comparative_efficacy_of_piperine_and_curcumin_in_deltamethrin_induced_splenic_apoptosis_and_altered_immune_functions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-3575(15)00057-7 DB - PRIME DP - Unbound Medicine ER -