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Twin screw wet granulation: Binder delivery.
Int J Pharm. 2015 Jun 20; 487(1-2):124-34.IJ

Abstract

The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique. Furthermore, the effect of binder delivery and the change of screw configuration (conveying elements only and conveying elements with kneading elements) on the surface velocity of granules across the screw channel were investigated using particle image velocimetry (PIV). The binder was delivered in three ways; all solid binder incorporated with powder mixture, 50% of solid binder mixed with powder mixture and 50% mixed with water, all the solid binder dissolved in water. Incorporation of all solid binder with powder mixture resulted in the relatively longer residence time and higher torque, narrower granule size distribution, more spherical granules, weaker big-sized granules, stronger small-sized granules and better binder distribution compared to that in other two ways. The surface velocity of granules showed variation from one screw to another as a result of uneven liquid distribution as well as shown a reduction while introducing the kneading elements into the screw configuration.

Authors+Show Affiliations

Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK. Electronic address: msaleh1@sheffield.ac.uk.Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.GSK, Third Avenue, Harlow, Essex CM19 5AW, UK.Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25869451

Citation

Saleh, Mohammed F., et al. "Twin Screw Wet Granulation: Binder Delivery." International Journal of Pharmaceutics, vol. 487, no. 1-2, 2015, pp. 124-34.
Saleh MF, Dhenge RM, Cartwright JJ, et al. Twin screw wet granulation: Binder delivery. Int J Pharm. 2015;487(1-2):124-34.
Saleh, M. F., Dhenge, R. M., Cartwright, J. J., Hounslow, M. J., & Salman, A. D. (2015). Twin screw wet granulation: Binder delivery. International Journal of Pharmaceutics, 487(1-2), 124-34. https://doi.org/10.1016/j.ijpharm.2015.04.017
Saleh MF, et al. Twin Screw Wet Granulation: Binder Delivery. Int J Pharm. 2015 Jun 20;487(1-2):124-34. PubMed PMID: 25869451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Twin screw wet granulation: Binder delivery. AU - Saleh,Mohammed F, AU - Dhenge,Ranjit M, AU - Cartwright,James J, AU - Hounslow,Michael J, AU - Salman,Agba D, Y1 - 2015/04/11/ PY - 2014/11/27/received PY - 2015/04/07/revised PY - 2015/04/09/accepted PY - 2015/4/15/entrez PY - 2015/4/15/pubmed PY - 2016/2/18/medline KW - Granule properties KW - Online binder distribution KW - PIV KW - Twin screw KW - Wet granulation SP - 124 EP - 34 JF - International journal of pharmaceutics JO - Int J Pharm VL - 487 IS - 1-2 N2 - The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique. Furthermore, the effect of binder delivery and the change of screw configuration (conveying elements only and conveying elements with kneading elements) on the surface velocity of granules across the screw channel were investigated using particle image velocimetry (PIV). The binder was delivered in three ways; all solid binder incorporated with powder mixture, 50% of solid binder mixed with powder mixture and 50% mixed with water, all the solid binder dissolved in water. Incorporation of all solid binder with powder mixture resulted in the relatively longer residence time and higher torque, narrower granule size distribution, more spherical granules, weaker big-sized granules, stronger small-sized granules and better binder distribution compared to that in other two ways. The surface velocity of granules showed variation from one screw to another as a result of uneven liquid distribution as well as shown a reduction while introducing the kneading elements into the screw configuration. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/25869451/Twin_screw_wet_granulation:_Binder_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(15)00325-7 DB - PRIME DP - Unbound Medicine ER -