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Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children.
Gene 2015; 566(1):68-73GENE

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable disorder of school-age children. Its heritability was estimated at 80-90% but the genetic component underpinning this disorder remains to be disclosed. Recently, a highly consistent association between latrophilin3 (LPHN3) gene and ADHD was reported. In the present study, we examined the association between the LPHN3 rs6551665 A/G polymorphism and ADHD in Korea. The samples used in the study consisted of 150 ADHD children and 322 controls. The ADHD children were diagnosed according to DSM-IV. ADHD symptoms were evaluated with Dupaul Parent ADHD Rating Scales. LPHN3 rs6551665 SNP was determined by PCR-RFLP. Hardy-Weinberg equilibrium, genotype and allele frequency differences between the case and the control, and odds ratio were examined using the chi-square and exact tests. The LPHN3 gene locus was found to have no deviation from the Hardy-Weinberg expectation. We observed a significant association between the ADHD children and control group in genotype frequency (p=0.01) and allele frequency (p=0.02). The ADHD children appeared to have a surplus of GG genotype (OR 2.959, 95% CI 1.416-6.184, p=0.003) and G allele (OR 1.44, 95% CI 1.062-1.945, p=0.02). The association was more distinctive when analysis was confined to male samples (p=0.005), the OR of male controls and cases was 4.029 (95% CI 1.597-10.164, p=0.002) and the OR having G allele vs. A allele was 1.46 (95% CI 1.002-2.127, p=0.048). Thus our results imply that the LPHN3 rs6551665 GG genotype and G allele may provide a significant effect on the ADHD, although larger sample sizes and functional studies are necessary to further elucidate these findings.

Authors+Show Affiliations

Department of Nanobiomedical Science, College of Natural Science, Dankook University, Cheonan, South Korea; Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea.Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea; Department of Psychology, College of Public Welfare, Dankook University, Cheonan, South Korea.Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea; Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, South Korea.Department of Nanobiomedical Science, College of Natural Science, Dankook University, Cheonan, South Korea; Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea. Electronic address: jins4658@dankook.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25871512

Citation

Hwang, In Wook, et al. "Association of LPHN3 Rs6551665 A/G Polymorphism With Attention Deficit and Hyperactivity Disorder in Korean Children." Gene, vol. 566, no. 1, 2015, pp. 68-73.
Hwang IW, Lim MH, Kwon HJ, et al. Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children. Gene. 2015;566(1):68-73.
Hwang, I. W., Lim, M. H., Kwon, H. J., & Jin, H. J. (2015). Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children. Gene, 566(1), pp. 68-73. doi:10.1016/j.gene.2015.04.033.
Hwang IW, et al. Association of LPHN3 Rs6551665 A/G Polymorphism With Attention Deficit and Hyperactivity Disorder in Korean Children. Gene. 2015 Jul 15;566(1):68-73. PubMed PMID: 25871512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children. AU - Hwang,In Wook, AU - Lim,Myung Ho, AU - Kwon,Ho Jang, AU - Jin,Han Jun, Y1 - 2015/04/12/ PY - 2014/10/11/received PY - 2015/04/07/revised PY - 2015/04/10/accepted PY - 2015/4/15/entrez PY - 2015/4/15/pubmed PY - 2015/7/28/medline KW - ADHD KW - Children KW - Genetic association KW - Korean KW - LPHN3 KW - Polymorphism KW - rs6551665 SP - 68 EP - 73 JF - Gene JO - Gene VL - 566 IS - 1 N2 - Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable disorder of school-age children. Its heritability was estimated at 80-90% but the genetic component underpinning this disorder remains to be disclosed. Recently, a highly consistent association between latrophilin3 (LPHN3) gene and ADHD was reported. In the present study, we examined the association between the LPHN3 rs6551665 A/G polymorphism and ADHD in Korea. The samples used in the study consisted of 150 ADHD children and 322 controls. The ADHD children were diagnosed according to DSM-IV. ADHD symptoms were evaluated with Dupaul Parent ADHD Rating Scales. LPHN3 rs6551665 SNP was determined by PCR-RFLP. Hardy-Weinberg equilibrium, genotype and allele frequency differences between the case and the control, and odds ratio were examined using the chi-square and exact tests. The LPHN3 gene locus was found to have no deviation from the Hardy-Weinberg expectation. We observed a significant association between the ADHD children and control group in genotype frequency (p=0.01) and allele frequency (p=0.02). The ADHD children appeared to have a surplus of GG genotype (OR 2.959, 95% CI 1.416-6.184, p=0.003) and G allele (OR 1.44, 95% CI 1.062-1.945, p=0.02). The association was more distinctive when analysis was confined to male samples (p=0.005), the OR of male controls and cases was 4.029 (95% CI 1.597-10.164, p=0.002) and the OR having G allele vs. A allele was 1.46 (95% CI 1.002-2.127, p=0.048). Thus our results imply that the LPHN3 rs6551665 GG genotype and G allele may provide a significant effect on the ADHD, although larger sample sizes and functional studies are necessary to further elucidate these findings. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/25871512/Association_of_LPHN3_rs6551665_A/G_polymorphism_with_attention_deficit_and_hyperactivity_disorder_in_Korean_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(15)00442-4 DB - PRIME DP - Unbound Medicine ER -