Tags

Type your tag names separated by a space and hit enter

Immunogenicity of Haemophilus influenzae oligosaccharide-protein and polysaccharide-protein conjugate vaccination of children at 4, 6, and 14 months of age.
Pediatrics. 1989 Dec; 84(6):995-9.Ped

Abstract

At 4 and 6 months of age, 118 infants were vaccinated with either one of two Haemophilus influenzae type b capsular polysaccharide-protein conjugate vaccines: 72 infants received the polysaccharide coupled to diphtheria toxoid (PRP-D group), and 46 infants received polysaccharide-derived oligosaccharides coupled to CRM197 protein, a nontoxic mutant form of diphtheria toxin (HbOC group). A third dose of the same vaccine was given to 40 children in the PRP-D group and 25 children in the HbOC group at 14 months of age. Antibodies to the H influenzae type b capsular polysaccharide were measured by Farr-type radioimmunoassay in serum samples taken before each vaccination and 1 month after the second and the third doses. Adverse reactions monitored by a questionnaire were mild. After two vaccine doses, the geometric mean concentration of antibodies to H influenzae type b polysaccharide increased from 0.07 micrograms/mL in the prevaccination samples to 0.63 micrograms/mL in the PRP-D group and to 4.32 micrograms/mL in the HbOC group. In the following 7 months, the geometric mean concentrations declined to 0.38 and 1.12 micrograms/mL, respectively. The booster dose given at 14 months elicited a strong antibody response in both groups (to geometric mean concentrations of 29.7 and 58.3 micrograms/mL, respectively). Both vaccines appear to be capable of immunologic priming by immunization in infancy.

Authors+Show Affiliations

Käyhty H
National Public Health Institute, Helsinki, Finland.
Peltola H
No affiliation info available
Eskola J
No affiliation info available
Rönnberg PR
No affiliation info available
Kela E
No affiliation info available
Karanko V
No affiliation info available
Mäkelä PH
No affiliation info available

MeSH

Age FactorsAntibodies, ViralAntibody FormationBacterial VaccinesDiphtheria ToxoidHaemophilus VaccinesHumansImmunization ScheduleInfant

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2587155

Citation

Käyhty, H, et al. "Immunogenicity of Haemophilus Influenzae Oligosaccharide-protein and Polysaccharide-protein Conjugate Vaccination of Children at 4, 6, and 14 Months of Age." Pediatrics, vol. 84, no. 6, 1989, pp. 995-9.
Käyhty H, Peltola H, Eskola J, et al. Immunogenicity of Haemophilus influenzae oligosaccharide-protein and polysaccharide-protein conjugate vaccination of children at 4, 6, and 14 months of age. Pediatrics. 1989;84(6):995-9.
Käyhty, H., Peltola, H., Eskola, J., Rönnberg, P. R., Kela, E., Karanko, V., & Mäkelä, P. H. (1989). Immunogenicity of Haemophilus influenzae oligosaccharide-protein and polysaccharide-protein conjugate vaccination of children at 4, 6, and 14 months of age. Pediatrics, 84(6), 995-9.
Käyhty H, et al. Immunogenicity of Haemophilus Influenzae Oligosaccharide-protein and Polysaccharide-protein Conjugate Vaccination of Children at 4, 6, and 14 Months of Age. Pediatrics. 1989;84(6):995-9. PubMed PMID: 2587155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of Haemophilus influenzae oligosaccharide-protein and polysaccharide-protein conjugate vaccination of children at 4, 6, and 14 months of age. AU - Käyhty,H, AU - Peltola,H, AU - Eskola,J, AU - Rönnberg,P R, AU - Kela,E, AU - Karanko,V, AU - Mäkelä,P H, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 995 EP - 9 JF - Pediatrics JO - Pediatrics VL - 84 IS - 6 N2 - At 4 and 6 months of age, 118 infants were vaccinated with either one of two Haemophilus influenzae type b capsular polysaccharide-protein conjugate vaccines: 72 infants received the polysaccharide coupled to diphtheria toxoid (PRP-D group), and 46 infants received polysaccharide-derived oligosaccharides coupled to CRM197 protein, a nontoxic mutant form of diphtheria toxin (HbOC group). A third dose of the same vaccine was given to 40 children in the PRP-D group and 25 children in the HbOC group at 14 months of age. Antibodies to the H influenzae type b capsular polysaccharide were measured by Farr-type radioimmunoassay in serum samples taken before each vaccination and 1 month after the second and the third doses. Adverse reactions monitored by a questionnaire were mild. After two vaccine doses, the geometric mean concentration of antibodies to H influenzae type b polysaccharide increased from 0.07 micrograms/mL in the prevaccination samples to 0.63 micrograms/mL in the PRP-D group and to 4.32 micrograms/mL in the HbOC group. In the following 7 months, the geometric mean concentrations declined to 0.38 and 1.12 micrograms/mL, respectively. The booster dose given at 14 months elicited a strong antibody response in both groups (to geometric mean concentrations of 29.7 and 58.3 micrograms/mL, respectively). Both vaccines appear to be capable of immunologic priming by immunization in infancy. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/2587155/Immunogenicity_of_Haemophilus_influenzae_oligosaccharide_protein_and_polysaccharide_protein_conjugate_vaccination_of_children_at_4_6_and_14_months_of_age_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓7]

Related Citations

More